Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer

Pretargeted immuno-PET imaging based on the bioorthogonal chemistry between ¹⁸F-labeled Reppe anhydride derivatives and tetrazine conjugates of the EGFR-specific monoclonal antibodies cetuximab and panitumumab was performed. This pretargeting approach yielded high target-to-nontarget ratios. Furthermore, due to the fast clearance rate of the PET probe, the overall radiation burden to nontarget tissues was also substantially decreased

Induced Decomposition and Slip Interface Transformation of Oleic Acid Enables Ultralow Wear in Boundary Lubrication

The tribological behavior of carboxylic acids, especially oleic acid, in boundary lubrication conditions is a subject of interest. This study presents the results of four-ball tribological tests conducted under varying contact pressures and sliding speeds. The findings reveal a critical turning speed within a confined zone, which causes a significant change in the frictional performances of oleic acid, leading to the formation of an ultralow wear tribofilm. This tribofilm, predominantly composed of oxyhydrogen compounds and hydrocarbons with more than five carbon atoms, is generated by the molecular action of oleic acid. Reactive nonequilibrium molecular dynamics simulations demonstrate that the shear speed-dependent decomposition modes of oleic acid and the transformation of the lubrication slip interface are the fundamental processes underlying the formation of this ultralow-wear boundary tribofilm

Induced Decomposition and Slip Interface Transformation of Oleic Acid Enables Ultralow Wear in Boundary Lubrication

The tribological behavior of carboxylic acids, especially oleic acid, in boundary lubrication conditions is a subject of interest. This study presents the results of four-ball tribological tests conducted under varying contact pressures and sliding speeds. The findings reveal a critical turning speed within a confined zone, which causes a significant change in the frictional performances of oleic acid, leading to the formation of an ultralow wear tribofilm. This tribofilm, predominantly composed of oxyhydrogen compounds and hydrocarbons with more than five carbon atoms, is generated by the molecular action of oleic acid. Reactive nonequilibrium molecular dynamics simulations demonstrate that the shear speed-dependent decomposition modes of oleic acid and the transformation of the lubrication slip interface are the fundamental processes underlying the formation of this ultralow-wear boundary tribofilm

Enhanced Wettability and Transport Control of Ultrafiltration and Reverse Osmosis Membranes with Grafted Polyelectrolytes

End-functionalized poly­(acrylic acid) (PAA-silane) was synthesized with reversible addition–fragmentation chain-transfer (RAFT) polymerization and attached to both polysulfone ultrafiltration (UF) and polyamide reverse osmosis (RO) membranes through a nonimpairing, one-step <i>grafting to</i> approach in order to improve membrane surface wettability with minimal impact on membrane transport performance. After PAA grafting, composition and morphology changes on the membrane surface were characterized with Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Static contact angle on PAA grafted membranes exhibited an increase in surface hydrophilicity and hence a potential enhancement in antifouling performance. The native contact angle on the polysulfone membrane systems was 86° and was reduced to 24° after modification, while the polyamide film contact angle decreased from 58° to 25°. The PAA layer endowed the porous UF membrane with dynamic control over the permeability and selectivity through the manipulation of the solution pH. The UF membrane with a 35 nm average pore size displayed a 115% increase in flux when the contact solution was changed from pH 11 to pH 3. This effect was diminished to 70% and 32% as the average pore size decreased to 20 and 10 nm, respectively. Modified RO membranes displayed no reduction in membrane performance indicating that the underlying materials were unaffected by the modification environment or added polymer. Model polyamide and polysulfone surfaces were reacted with the PAA-silane inside a quartz crystal microbalance (QCM) to help inform the deposition behavior for the respective membrane chemistries

Induced Decomposition and Slip Interface Transformation of Oleic Acid Enables Ultralow Wear in Boundary Lubrication

The tribological behavior of carboxylic acids, especially oleic acid, in boundary lubrication conditions is a subject of interest. This study presents the results of four-ball tribological tests conducted under varying contact pressures and sliding speeds. The findings reveal a critical turning speed within a confined zone, which causes a significant change in the frictional performances of oleic acid, leading to the formation of an ultralow wear tribofilm. This tribofilm, predominantly composed of oxyhydrogen compounds and hydrocarbons with more than five carbon atoms, is generated by the molecular action of oleic acid. Reactive nonequilibrium molecular dynamics simulations demonstrate that the shear speed-dependent decomposition modes of oleic acid and the transformation of the lubrication slip interface are the fundamental processes underlying the formation of this ultralow-wear boundary tribofilm

Induced Decomposition and Slip Interface Transformation of Oleic Acid Enables Ultralow Wear in Boundary Lubrication

The tribological behavior of carboxylic acids, especially oleic acid, in boundary lubrication conditions is a subject of interest. This study presents the results of four-ball tribological tests conducted under varying contact pressures and sliding speeds. The findings reveal a critical turning speed within a confined zone, which causes a significant change in the frictional performances of oleic acid, leading to the formation of an ultralow wear tribofilm. This tribofilm, predominantly composed of oxyhydrogen compounds and hydrocarbons with more than five carbon atoms, is generated by the molecular action of oleic acid. Reactive nonequilibrium molecular dynamics simulations demonstrate that the shear speed-dependent decomposition modes of oleic acid and the transformation of the lubrication slip interface are the fundamental processes underlying the formation of this ultralow-wear boundary tribofilm

Phylogenetic tree of acid invertase proteins from <i>Populus</i>, <i>Arabidopsis</i> and Medicago.

<p>The α clade contains cell-wall invertases (<i>PtrCWINV1</i>-<i>5</i>) and the β clade contains vacuolar invertases (<i>PtrVINV1</i>-<i>3</i>).</p

Numbers of invertase genes within each plant species according to transcript data.

<p>Numbers of invertase genes within each plant species according to transcript data.</p

Expression profiles obtained by RNA-seq for <i>Populus</i> invertase genes in leaf buds.

<p>LLB, latent leaf buds; GLB, leaf buds at germination.</p

Expression analyses obtained by RNA-seq for <i>Populus</i> invertase genes in roots, stems and leaves.

<p>On the x-axis: Rt, roots; St, stems; Lf, leaves.</p