Rethinking preemptive consumption: building mechanisms of reciprocity, contextuality, and risk hedging across scenarios

Confronted with fragmentation and retardation in understanding preemption, the authors aim to reassemble the current understanding of preemptive behaviors. Hence, we re-examine multiple mechanisms with three aspects of drive: expectancy, situational, and temporal factors, rooted in consumer psychology and cognition of social crises. Preemptive consumption occurs via three pathways. First, in the explanation of drives, objective-bound motivation, moderated by the opportunism of the outcome, can intensify the intention to behave preemptively, which echoes and extends expectation theory into self-other dual polarity. Second, from the perspective of the behavioral sequence, a defensive or aggressive strategy, tuned by the level of the behavioral barrier, can strengthen the inclination to act preemptively. Finally, an individual's concern about scarcity and the risk of farsightedness, altered by their capacity to handle inequality and threats, impacts preemptive behavior. This study has significant implications for leveraging individual motivations, ethics, and consumer-targeted communication tools.</p

Rethinking preemptive consumption: building mechanisms of reciprocity, contextuality, and risk hedging across scenarios

Confronted with fragmentation and retardation in understanding preemption, the authors aim to reassemble the current understanding of preemptive behaviors. Hence, we re-examine multiple mechanisms with three aspects of drive: expectancy, situational, and temporal factors, rooted in consumer psychology and cognition of social crises. Preemptive consumption occurs via three pathways. First, in the explanation of drives, objective-bound motivation, moderated by the opportunism of the outcome, can intensify the intention to behave preemptively, which echoes and extends expectation theory into self-other dual polarity. Second, from the perspective of the behavioral sequence, a defensive or aggressive strategy, tuned by the level of the behavioral barrier, can strengthen the inclination to act preemptively. Finally, an individual's concern about scarcity and the risk of farsightedness, altered by their capacity to handle inequality and threats, impacts preemptive behavior. This study has significant implications for leveraging individual motivations, ethics, and consumer-targeted communication tools.</p

Long-Term Efficient Interfacial Solar Desalination Enabled by a Biomimetic 2D Water-Transport Structure Based on Silicone Nanofilaments

Solar-driven interfacial evaporation (SIE) has drawn increasing attention for seawater desalination. Two-dimensional water-transport structures (2D-WTS) can enhance SIE performance by reducing heat loss of conventional evaporators but suffer from poor salt resistance due to insufficient water supply, which inhibits vapor escape and thus reduces evaporation rate. Inspired by the transpiration of plant leaves, we report the design of a 2D-WTS with controllable morphology by growing silicone nanofilaments on a polyethylene/polypropylene fabric. 2D-WTS has a hierarchical micro-/nanostructure for fast water supply like the multiscale vascular system of leaves. Consequently, the separated solar evaporator composed of 2D-WTS and polypyrrole/attapulgite@aluminium photothermal sheet achieves long-term efficient SIE, i.e., high evaporation rate (2.23 kg m–2 h–1, 3.5 wt % NaCl(aq), 1 sun), stable SIE of concentrated brine over 10 days (∼2.10 kg m–2 h–1, 10 wt % NaCl(aq), 7 h irradiation per day, 1 sun), and high practical evaporation rate of 7.36 kg m–2 during 7 h outdoor SIE under weak sunlight and low temperature (0.3–0.6 sun, 2–13 °C). This is because fast water transport in 2D-WTS forms a small salt deposition area close to the edge of the horizontal area of 2D-WTS during long-term SIE, which hardly affects the vapor escape

Long-Term Efficient Interfacial Solar Desalination Enabled by a Biomimetic 2D Water-Transport Structure Based on Silicone Nanofilaments

Solar-driven interfacial evaporation (SIE) has drawn increasing attention for seawater desalination. Two-dimensional water-transport structures (2D-WTS) can enhance SIE performance by reducing heat loss of conventional evaporators but suffer from poor salt resistance due to insufficient water supply, which inhibits vapor escape and thus reduces evaporation rate. Inspired by the transpiration of plant leaves, we report the design of a 2D-WTS with controllable morphology by growing silicone nanofilaments on a polyethylene/polypropylene fabric. 2D-WTS has a hierarchical micro-/nanostructure for fast water supply like the multiscale vascular system of leaves. Consequently, the separated solar evaporator composed of 2D-WTS and polypyrrole/attapulgite@aluminium photothermal sheet achieves long-term efficient SIE, i.e., high evaporation rate (2.23 kg m–2 h–1, 3.5 wt % NaCl(aq), 1 sun), stable SIE of concentrated brine over 10 days (∼2.10 kg m–2 h–1, 10 wt % NaCl(aq), 7 h irradiation per day, 1 sun), and high practical evaporation rate of 7.36 kg m–2 during 7 h outdoor SIE under weak sunlight and low temperature (0.3–0.6 sun, 2–13 °C). This is because fast water transport in 2D-WTS forms a small salt deposition area close to the edge of the horizontal area of 2D-WTS during long-term SIE, which hardly affects the vapor escape

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed