57 research outputs found
Physiologic Manifestations of Human Anapf is
A B S T R A C T In the course of a controlled study to evaluate different forms of immunotherapy for subjects with insect-sting hypersensitivity, we observed 11 subjects who had systemic cutaneous urticarial reactions and 3 subjects who experienced systemic anaphylaxis. With the exception of tachyeardia, there were no cardiopulmonary changes in the subjects with urticaria, whereas the major manifestation of anaphylactic shock in the other three subjects was severe hypotension that was probably secondary to peripheral vasodilation. Significant abnormalities in gas exchange developed in two subjects. In one, bronchospasm precipitated a respiratory arrest followed by endotracheal intubation with mechanical ventilation. Although plasma histamine levels were not related to the development of cutaneous reactions, the plasma histamine levels correlated with the severity and duration of the cardiopulmonary changes observed during anaphylactic shock. The two subjects with the most severe shock showed evidence of intravascular coagulation characterized by a diminution of Factor V, Factor VIII, fibrinogen, and high molecular weight kininogen, as well as changes in components of the complement system. Standard therapy with epinephrine and fluids, usually recommended for the treatment of systemic anaphylaxis, did not immediately reverse either the hemodynamic or the respiratory abnormalities in the two subjects with the most sever
A comprehensive analysis of the allergenicity and IgE epitopes of myosinogen allergens in Scylla paramamosain
Effects of arachidonic acid and its metabolites on antigen-induced histamine release from human basophils in vitro.
Possible role of phospholipase A2 in triggering histamine secretion from human basophils in vitro.
IgE-mediated histamine release from human basophils: differences between antigen E- and anti-IgE-induced secretion.
IgE-Mediated Histamine Release from Human Basophils: Differences between Antigen E- and Anti-IgE-Induced Secretion
Control mechanisms of histamine release from human basophils in vitro: the role of phospholipase A2 and of lipoxygenase metabolites.
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