Features of compiling metabolic correction programs for professional athletes and the possibility of their optimization using digital technologies

To compile a personalized program for correcting the metabolism of a professional athlete, it is necessary to take into account many factors, including age, gender, sports specialization, individual characteristics, the pathologies in the anamnesis, the stage of the athlete’s training cycle, etc. When drawing up such programs for athletes of sports national teams of the Russian Federation, a scheme for assessing the characteristics of the athlete’s body is used, the basis for which is information obtained during in-depth medical examinations of athletes conducted on the basis of clinics of the FMBA Russia. To improve the quality of personalized programs of metabolic correction in the future, it is possible to use professionally oriented reference intervals of laboratory blood parameters, as well as the results of genetic screening based on the strategy of complete exomic sequencing of the athlete’s genome. One of the ways to increase the efficiency of metabolic correction of professional athletes is the introduction of modern information technologies and the development of a modern information system based on them. The introduction of such an information system will increase the speed of primary processing of initial information about the health status of the athlete and the peculiarities of his metabolic processes, as well as partially automate the formation of individualized recommendations regarding the diet and hydratation, and the choice of metabolic correction at various stages of the sports season

Modern (rational) methods for detecting genetic features of athletes

Molecular genetic methods are an integral part of recent medicine. Polymerase chain reaction, Sanger sequencing, next-generation sequencing are widely used in many areas: diagnostics of infectious, inherited, oncological diseases, prenatal screening, study of polymorphisms that increase the risk of developing multifactorial diseases or promoting development physical qualities necessary to achieve success in sports and competitive activity. The growing demand for genotyping raises a number of ethical and social issues affecting the degree of usefulness of genotyping a healthy person and the scientific reliability of the data obtained using direct-to-consumer genetic testing.The review presents and systematizes the laboratory diagnostic methods used today to study nucleic acids that carry important information about human health and physical qualities

Personality profiles and the "russian soul": Literary and scholarly views evaluated

Many domestic and foreign observers have claimed that Russians have a unique constellation of personality traits that mirrors their distinctive historical and cultural experience. To examine the hypothesized uniqueness of Russian personality, members of the Russian Character and Personality Survey collected data from 39 samples in 33 administrative areas of the Russian Federation. Respondents (N = 7,065) identified an ethnically Russian adult or college-aged man or woman whom they knew well and rated the target using the Russian observer-rating version of the Revised NEO Personality Inventory. The mean personality profile of Russians was very similar to the international average based on 50 different countries, debunking the myth of a unique Russian soul.The small variations from world norms did not converge with depictions of Russian national character in fiction and the scholarly literature. New items intended to capture distinctive, emic aspects of Russian personality provided no new information beyond the familiar Big Five dimensions. Religion, ethnicity, and beliefs about the uniqueness of the Russian character and the malleability of personality traits had little effect on personality ratings. Perceptions of the Russian soul do not seem to be based on the personality traits of Russians

Epoxy composites with increased operational characteristics, filled with dispersed mineral fillers

The aim of this work is to increase the physicochemical, deformation and strength properties and to reduce the combustibility of composites on the base of epoxy resin by introducing a oligo(resorcinophenyl phosphate) with terminal phenyl groups Fyrolflex - modifier of polyfunctional action, and disperse mineral fillers – diorite and chromite. Result of the studies established that the optimum amount of modifier in the composition of the epoxy resin is 40 mass parts, which provides an increase in the operational properties of the composites: the breaking stress at bending increases by 2 times, the breaking stress at compression increases by 28%, the impact strength increases twice, while the modulus of elasticity and hardness of composites slightly decrease. The addition of modifier into the epoxy polymer provides an increase in heat resistance from 86 to 132–156 °C, also it improves the thermal stability of the composite, which manifests itself in a shift from the initial temperature to higher temperatures (from 200 to 230 °C), while it is noticed furthermore that yield of carbonized Structures was risen from 40 to 54%, providing less release of volatile pyrolysis products into the gas phase, which leads to the decrease in flammability of the epoxy composite and it can be shown in the reduction of its loss in mass while cauterizing in air from 78 to about 4.7% and an increase in the oxygen index from 19 to 28% by volume what transfers the material into class with low flammability. The rational content of diorite and chromite (100 parts by weight of chromite and 50 parts by mass of diorite) is chosen as a filler, which ensures an increase in physical and mechanical characteristics and a reduction in the cost of production: the breaking stress increases by 15–30% and the elastic modulus at bending increases 3.5–4.5 times, the breaking stress increases by 35%, and the tensile modulus by 50–240%, the hardness increases by 68–95%, while the impact strength remains at the level of the unfilled plasticized composite. In addition, it is proved that the addition of both diorite and chromite provides an increase in the thermal and heat resistance of epoxy composites, also lowers combustibility of the epoxy composite: the weight loss at ignition in air is reduced to 1.2–2.2% and the oxygen index rises from 28 to 30–35% by volume, thus the material does not support combustion in air and belongs to the class of hardly flammable. The study was carried out with the financial support of a grant for young scientists of the SSTU named after Gagarin Yu.A. (project SGTU-287)

Complex-modified basalt plastics

In view of the fact that the creation and development of the production of new polymers practically does not occur, the modification of known materials, the creation of polymer composites filled with various substances is today one of the priority directions in the creation of new polymeric materials. In this paper, the possibility of increasing the reactivity by processing corona discharge of large-capacity polymer-polyethylene when filled with modified basalt. The method of full factorial experiment, regression equations, analysis of which showed a prevailing influence of DC corona discharge on the physico-mechanical characteristics of polymeric composite materials. The optimal ratio of the components of the composite material and the current during the processing of polyethylene corona discharge were chosen by gradient method. The prospects and expediency of obtaining complex-modified basalt plastics on the basis of low-pressure polyethylene treated with corona discharge are proved, since all physical, chemical and mechanical properties of polyethylene composites are increased. The method of infrared spectroscopy shows that in a complex-modified basalt plastic there are practically no groups of hydroxyl groups, the intensity of peaks of methylol groups and peaks –Si-O-Si-is significantly reduced, which indicates the chemical interaction of polyethylene treated with corona discharge and modified basalt

Method of formation of pancreatoenteroanastomosis in pancreatoduodenal resection

OBJECTIVE. Тhе article considered the various modern techniques of panсreatoenteroanastomosis formation and their results from critical positions. MATERIAL AND METHODS. The authors suggested to apply a new method of panсreatoenteroanastomosis formation in order to decrease the rate of lethality, postoperative complications and traumatic conditions after operation. RESULTS. The developed method of panсreatoenteroanastomosis formation was used in 25 patients with chronic pancreatitis at the period from 2015 to 2016. CONCLUSIONS. The satisfactory results were obtained and that confirmed the efficacy and significance of the method

Structure of O-Polysaccharide and Lipid A of Pantoea Agglomerans 8488

The Pantoea agglomerans 8488 lipopolysaccharide (LPS) was isolated, purified and characterized by monosaccharide and fatty acid analysis. The O-polysaccharide and lipid A components of the LPS were separated by mild acid degradation. Lipid A was studied by electrospray ionization mass spectrometry (ESI-MS) and found to consist of hexa-, penta-, tetra- and tri-acylated species. Two-dimensional nuclear magnetic resonance (NMR) spectroscopy revealed the following structure of the O-polysaccharide repeating unit →3)-α-L-Rhap-(1→6)-α-D-Manp-(1→3)-α-L-Fucp-(1→3)-β-D-GlcNAcp-(1→. The LPS showed a low level of toxicity, was not pyrogenic, and reduced the adhesiveness index of microorganisms to 2.12, which was twofold less than the control. LPS modified by complex compounds of germanium (IV) and tin (IV) were obtained. It was found that six LPS samples modified by Sn compounds and two LPS samples modified by Ge compounds lost their toxic activity when administered to mice in a dose of LD50 (105 µg/mice or 5 mg/kg). However, none of the modified LPS samples changed their serological activity in an Ouchterlony double immunodiffusion test in agar