Late perforation of anterior mitral leaflet after surgical resection of the subaortic membrane

AbstractA 54-year-old woman who underwent surgical resection of the subaortic membrane 10 years earlier presented with new onset dyspnea. Cardiovascular examination revealed 3–4/6 pansystolic murmur at the apex. She was found to have severe mitral regurgitation (MR) with transthoracic echocardiography; 2D and real-time-3D transesophageal echocardiography demonstrated severe MR through anterior mitral leaflet perforation with precise localization. The patient was treated with surgery in which the perforated segment was closed by direct suture technique and discharged on postoperative 5th day.<Learning objective: Late anterior mitral leaflet perforation after surgical or interventional procedures has rarely been reported. We present this case to emphasize the role of traumatic injury to weak endothelial surfaces such as a valve leaflet in the development of late leaflet perforation after surgical or interventional procedures.

Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems

Introduction. Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described. Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems. Patients and Methods. Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC, ) and Group II (noncoated, ) ECC circuits. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor-&alpha; (TNF-&alpha;), Interleukin-1&beta; (IL-&beta;), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), and Procalcitonin (PCT) levels were measured at 5 different time points. The association between the oxidative indices levels and PCC system used was analyzed. Results. In Group I TOS and TAS statuses were increased at , , , and , while IL-10 and TNF-&alpha; levels accompanied those raises only at (Group I-Group II, versus , , and versus , , resp.). In contrast, mean TAS and TOS levels were similar to baseline at all time points in Group II but IL-6 and IL-8 levels were increased at (Group I-Group II, versus , , and versus , , resp.). Conclusion. Even coated ECC systems are still incapable of attenuating the inflammatory response to cardiopulmonary bypass (CPB)

Ventricular Septal Defect Closure in a Patient with VACTERL Syndrome: Anticipating Sequelae in a Rare Genetic Disorder

Noncardiac components of genetic disorders can complicate the operative and postoperative courses of pediatric cardiac surgery patients. Prolonged hospital stay, increased treatment cost, morbidity, and death are more likely in this subgroup of patients

Respiratory and clinical outcomes after coronary artery bypass surgery in male patients below and over 70 years of age

Background: This retrospective study was planned to evaluate respiratory functions and clinical outcomes in male patients below and over 70 years of age after coronary artery bypass surgery (CABS)

Phosphorylcholine-coated extracoporeal circulation systems affect coagulation factors during cardiopulmonary bypass insufficiently: a preliminary report

Background: This study aims to investigate the efficacy of the phosphorylcholine (PC)-coated extracorporeal circulation (ECC) circuits compared to the non-coated ECC circuits in patients undergoing isolated coronary artery bypass grafting (CABG)