Psoriasis Pustular Generalisata yang Diterapi dengan Kortikosteroid Sistemik

Psoriasis pustular generalisata atau yang sering juga disebut Von Zumbusch merupakan bentuk psoriasis inflamatori yang jarang terjadi dan secara klinis berkarakteristik demam yang diikuti dengan erupsi generalisata pus steril dengan diameter 2-3mm pada kulit yang eritem. Pengobatan yang umumnya digunakan adalah etretinate, methotrexate (MTX), cyclosporine, infliximab, atau kortikosteroid sistemik. Kami memaparkan seorang wanita berusia 39 tahun dengan psoriasis pustular generalisata yang diterapi dengan kortikosteroid sistemik.Kata kunci : psoriasis pustular generalisata, Von Zumbusch, terapi, kortikostresoid sistemi

Alternative Leprosy Treatment Using Rifampicin Ofloxacin Minocycline (ROM) Regimen – Two Case Reports

Introduction. Leprosy is a disease that predominantly affects the skin and peripheral nerves, resulting in neuropathy and associated long-term consequences, including deformities and disabilities. According to the WHO classification, there are two categories of leprosy, paucibacillary (PB) and multibacillary (MB). The standard treatment for leprosy employs the use of WHO MDT (Multi Drug Treatment) regimen, despite its multiple downsides such as clofazimine-induced pigmentation, dapsone-induced haematological adverse effects, poor compliance due to long therapy duration, drug resistance, and relapse. Multiple studies and case reports using ROM regimen have reported satisfactory results. Nevertheless, there are still insufficient data to elucidate the optimum dosage and duration of ROM regimen as an alternative treatment for leprosy. Previous experience from our institution revealed that ROM regimen given three times weekly resulted in a satisfactory outcome