High-resolution nested model for the Lebanese coastal area, Eastern Mediterranean: implementation and climatological runs

International audienceAs a part of the project Mediterranean Network to Assess and Upgrade Monitoring and Forecasting Activity in the Region (MAMA) we implemented a high resolution nested hydrodynamic model (1/40° horizontal grid, 16 sigma levels) for the coastal, shelf and open sea areas off the Lebanese coast, East Levantine Basin of the Eastern Mediterranean Sea. The Lebanese Shelf Model (LSM) is a version of the Princeton Ocean Model (POM). It is nested in a coarse resolution model the Aegean Levantine Eddy Resolving Model (1/20° horizontal grid, 25 sigma levels), ALERMO, that covers the Eastern Mediterranean. The nesting is one way so that velocity, temperature, and salinity along the open boundaries are interpolated from the relevant coarse model variables. Numerical simulations have been carried out under climatological surface and lateral forcing. Due to the relatively small domain, the results closely follow the simulation of the intermediate model with more details especially over the narrow shelf region. Simulations reproduce main circulation features and coastal circulation characteristics over the eastern Levantine shelf. This paper describes the modeling system setup, compares the simulations with the corresponding results of the coarse model ALERMO, and with the observed climatological circulation characteristics in the Levantine Basin off the Lebanese coast

Towards Software-Defined Protection, Automation, and Control in Power Systems: Concepts, State of the Art, and Future Challenges

Nowadays, power systems’ Protection, Automation, and Control (PAC) functionalities are often deployed in different constrained devices (Intelligent Electronic Devices) following a coupled hardware/software design. However, with the increase in distributed energy resources, more customized controllers will be required. These devices have high operational and deployment costs with long development, testing, and complex upgrade cycles. Addressing these challenges requires that a ’revolution’ in power system PAC design takes place. Decoupling from hardware-dependent implementations by virtualizing the functionalities facilitates the transition from a traditional power grid into a software-defined smart grid. This article presents a survey of recent literature on software-defined PAC for power systems, covering the concepts, main academic works, industrial proof of concepts, and the latest standardization efforts in this rising area. Finally, we summarize the expected future technical, industrial, and standardization challenges and open research problems. It was observed that software-defined PAC systems have a promising potential that can be leveraged for future PAC and smart grid developments. Moreover, standardizations in virtual IED software development and deployments, configuration tools, performance benchmarking, and compliance testing using a dynamic, agile approach assuring interoperability are critical enablers. © 2022 by the authors

Complications and pitfalls of lumbar interlaminar and transforaminal epidural injections

Lumbar interlaminar and transforaminal epidural injections are used in the treatment of lumbar radicular pain and other lumbar spinal pain syndromes. Complications from these procedures arise from needle placement and the administration of medication. Potential risks include infection, hematoma, intravascular injection of medication, direct nerve trauma, subdural injection of medication, air embolism, disc entry, urinary retention, radiation exposure, and hypersensitivity reactions. The objective of this article is to review the complications of lumbar interlaminar and transforaminal epidural injections and discuss the potential pitfalls related to these procedures. We performed a comprehensive literature review through a Medline search for relevant case reports, clinical trials, and review articles. Complications from lumbar epidural injections are extremely rare. Most if not all complications can be avoided by careful technique with accurate needle placement, sterile precautions, and a thorough understanding of the relevant anatomy and contrast patterns on fluoroscopic imaging

Shehabism in Lebanon 1958-1970 The failure of a hegemonic project

For maps accompanying this thesis please apply direct to the issuing universitySIGLEAvailable from British Library Document Supply Centre- DSC:D185887 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Through the Portal of Shame: A Path Toward Self-Love for Fatherless Daughters Living in Patriarchy

This thesis is a heuristic exploration, from a depth psychological perspective, of the relationship between shame and authentic voice for fatherless daughters living in a patriarchal culture. Literature is reviewed related to a definition of shame and understanding its etiology and psychological effects. Through a depth psychological analysis of the author’s personal experience of abandonment by her father, the path toward healing shame is revealed as the capacity to be vulnerable enough to tell one’s whole story in the presence of a loving and compassionate witness. This profoundly courageous act is what leads a fatherless daughter from a place of a silenced voice in the face of shame to a place of empowerment through sharing her authentic voice and moving toward psychological liberation

Specifications of a Simulation Framework for Virtualized Intelligent Electronic Devices in Smart Grids Covering Networking and Security Requirements

As power system's operational technology converges with innovative information and communication technologies, the need for extensive resilience testing for scenarios covering the electrical grid, networking bottlenecks, as well as cyber security threats, become a necessity. This paper proposes a comprehensive, multi-disciplinary simulation framework to test virtualized intelligent electronic devices (vIEDs), considering 1) functional requirements, 2) performance and quality of service of the underlying communication network using software-defined networking, and 3) cyber security intrusion detection schemes. This work serves as a reference for researchers interested in the grid modernization of information and communication infrastructure for future power systems. Six different cyber security attack surfaces have been identified within the framework scope. It was observed that migration of vIEDs due to device maintenance or external anomalies is interesting from an operational perspective yet still poses significant security threats. Therefore, both host-based and network-based intrusion detection schemes were analyzed. Also, the setup has been mapped to an offshore wind case study demonstrating its potential and possible scenarios to simulate

Neuropilins define distinct populations of neural crest cells

Background: Neural crest cells (NCCs) are a transient embryonic cell type that give rise to a wide spectrum of derivatives, including neurons and glia of the sensory and autonomic nervous system, melanocytes and connective tissues in the head. Lineage-tracing and functional studies have shown that trunk NCCs migrate along two distinct paths that correlate with different developmental fates. Thus, NCCs migrating ventrally through the anterior somite form sympathetic and sensory ganglia, whereas NCCs migrating dorsolaterally form melanocytes. Although the mechanisms promoting migration along the dorsolateral path are well defined, the molecules providing positional identity to sympathetic and sensory-fated NCCs that migrate along the same ventral path are ill defined. Neuropilins (Nrp1 and Nrp2) are transmembrane glycoproteins that are essential for NCC migration. Nrp1 and Nrp2 knockout mice have disparate phenotypes, suggesting that these receptors may play a role in sorting NCCs biased towards sensory and sympathetic fates to appropriate locations. Results: Here we have combined in situ hybridisation, immunohistochemistry and lineage-tracing analyses to demonstrate that neuropilins are expressed in a non-overlapping pattern within NCCs. Whereas Nrp1 is expressed in NCCs emigrating from hindbrain rhombomere 4 (r4) and within trunk NCCs giving rise to sympathetic and sensory ganglia, Nrp2 is preferentially expressed in NCCs emigrating from r2 and in trunk NCCs giving rise to sensory ganglia. By generating a tamoxifen-inducible lineage-tracing system, we further demonstrate that Nrp2-expressing NCCs specifically populate sensory ganglia including the trigeminal ganglia (V) in the head and the dorsal root ganglia in the trunk. Conclusions: Taken together, our results demonstrate that Nrp1 and Nrp2 are expressed in different populations of NCCs, and that Nrp2-expressing NCCs are strongly biased towards a sensory fate. In the trunk, Nrp2-expressing NCCs specifically give rise to sensory ganglia, whereas Nrp1-expressing NCCs likely give rise to both sensory and sympathetic ganglia. Our findings therefore suggest that neuropilins play an essential role in coordinating NCC migration with fate specification.Rachael Lumb, Sophie Wiszniak, Samuela Kabbara, Michaela Scherer, Natasha Harvey and Quenten Schwar

Comparative Pharmacodynamics of Gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa

Aminoglycosides are often used to treat severe infections with gram-positive organisms. Previous studies have shown concentration-dependent killing by aminoglycosides of gram-negative bacteria, but limited data are available for gram-positive bacteria. We compared the in vitro pharmacodynamics of gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa. Five S. aureus strains were examined (ATCC 29213 and four clinical isolates). Time-kill studies (TKS) in duplicate (baseline inocula of 10(7) CFU/ml) were conducted to evaluate bacterial killing in relation to increasing gentamicin concentrations (0 to 16 times the MIC). Serial samples were obtained over 24 h to quantify bacterial burden. Similar TKS with P. aeruginosa ATCC 27853 were conducted, and the time courses of the all bacterial strains were mathematically modeled for quantitative comparison. A dose fractionation study (using identical daily doses of gentamicin) in an in vitro hollow-fiber infection model (HFIM) over 5 days was subsequently used for data validation for the two ATCC strains. Model fits to the data were satisfactory; r(2) values for the S. aureus and P. aeruginosa ATCC strains were 0.915 and 0.956, respectively. Gentamicin was found to have a partially concentration-dependent killing effect against S. aureus; concentrations beyond four to 8 times the MIC did not result in significantly faster bacterial killing. In contrast, a concentration-dependent profile was demonstrated in suppressing P. aeruginosa regrowth after initial decline in bacterial burden. In HFIM, thrice-daily gentamicin dosing appeared to be superior to once-daily dosing for S. aureus, but they were similar for P. aeruginosa. Different killing profiles of gentamicin were demonstrated against S. aureus and P. aeruginosa. These results may guide optimal dosing strategies of gentamicin in S. aureus infections and warrant further investigations