52 research outputs found
HLA Class I Polymorphism in the Albanian Population
The HLA class I polymorphism was studied in a sample of the Albanian population. Ninety-three unrelated healthy Albanians were typed for HLA-A, -B and -Cw antigens by standard microlyphocytotoxicity test. The antigens with the highest frequencies were:
HLA-A2 (34.4%), A3 (14.5%) and A1 (12.4%); B51 (19.3%), B35 (12.4%) and B18 (10.2%); Cw4 (16.2%), Cw7 (16.2%) and Cw6 (10.8%). The HLA haplotypes with high frequency in Albanians included A2-B51 (4.3%), A2-B18 (2.4%), A2-B35 (2.4%), Cw4-B35 (7.6%), and Cw7-B18 (6.5%), which are not significantly different from the other neighboring populations. Low frequency of HLA-A1-B8 haplotype (1.1%) is noted in the Albanian population. The frequency of HLA-B27 antigen (1.1%) is one of the lowest frequencies observed in Caucasians. Such results are important in studies of HLA-A1-B8, HLA-B27 and disease associations. These findings should be also useful in understanding the origin of Albanians, representing a base for future studies about HLA polymorphism in the Albanian population
History of Chemistry and Chemical Engineering: Croatian Chemistry in the 20th Century. II. From the Collapse of Independent State of Croatia on May 8th, 1945 to the Establishment of the Republic of Croatia on June 25th, 1991.
Prikazan je dio razvoja hrvatske kemije od kraja II. svjetskoga rata i propasti Nezavisne Države Hrvatske do uspostave Republike Hrvatske. Ukratko je opisano utemeljenje i razvoj Kemijskoga odsjeka Prirodoslovno-matematiÄkoga fakulteta u Zagrebu i Instituta RuÄera BoÅ”koviÄ te organizacijsko nastavno unapreÄenje kemijsko-tehnoloÅ”koga studija. Razmatrana je organizacijska shema i nastava kemije te kemijska istraživanja na Prehrambeno-biotehnoloÅ”kome, Farmaceutsko- -biokemijskome, Medicinskome, Veterinarskome, Agronomskome i Å umarskome fakultetu SveuÄiliÅ”ta u Zagrebu. Älanak predstavlja nastavak naÅ”ega ranijega Älanka Hrvatska kemija u XX. stoljeÄu. I. Razdoblje od poÄetka stoljeÄa do 8. svibnja 1945. (Kem. Ind. 56 (2007) 403-416).The development of Croatian chemistry from the end of the Second World War to the establishment of the Republic of Croatia is outlined. Briefly discussed is the founding and development of the Chemistry Department of the Faculty of Natural Sciences and Mathematics, and the Rugjer BoÅ”koviÄ Institute. Also presented is the postwar structure and organization of the chemical- technological study at the Technical Faculty and later at the Faculty of Technology. The chemical lectures and research in chemistry at the Faculty of Nutrition and Biotechnology, Faculty of Pharmacy and Biochemistry, Faculty of Medicine, Faculty of Veterinary Medicine, Faculty
of Agronomy and Faculty of Forestry are reviewed. This article follows logically our first article in this series entitled Croatian Chemistry in the 20th Century. I. From the Turn of the Century to May 8,th 1945 (Kem. Ind. 56 (2007) 403ā416)
Osteoporosis in Men
Produženjem oÄekivanog trajanja života osteoporoza je postala rastuÄi problem u veÄini razvijenih zemalja svijeta. U radu se raspravlja o uÄestalosti, patogenezi, dijagnostiÄkim kriterijima i moguÄnostima lijeÄenja osteoporoze u muÅ”karaca. Svaki treÄi prijelom kuka dogaÄa se u muÅ”karaca, a viÅ”e od 11 % muÅ”karaca starijih od 50 godina doživi ovaj prijelom. Dijagnoza idiopatske osteoporoze primjenjuje se za muÅ”karce mlaÄe od 60 godina u kojih nema drugih moguÄih uzroka bolesti. U njih je niska mineralna gustoÄa kosti (BMD) najveÄim dijelom posljedica niske vrÅ”ne koÅ”tane mase. U oko 30 % muÅ”karaca nalazi se sekundarna osteoporoza, a involucijska osteoporoza nastaje u muÅ”karaca starijih od 60 godina, kao rezultat smanjenja koncentracije testosterona i IGF-1. S obzirom na rezultate istraživanja koja su pokazala da vrijednost BMD-a u oba spola pruža sliÄne informacije o riziku prijeloma, Äini se da se postojeÄi kriteriji za dijagnozu osteoporoze u žena mogu iskoristiti i za muÅ”karce. U lijeÄenju, bisfosfonati i teriparatid dokazano i znaÄajno poveÄavaju BMD u muÅ”karaca. Primjena androgena pokazala se uÄinkovitom u muÅ”karaca s hipogonadizmom, no opravdanost njihove primjene u eugonada joÅ” uvijek je predmet rasprava. PoveÄanjem znanja o metabolizmu kosti i koÅ”tanoj pregradnji u novije vrijeme otvorila su se vrata Äitavom nizu molekula koje bi u buduÄnosti mogle postati temelj lijeÄenja osteoporoze u muÅ”karaca.With the prolongation of life expectancy, osteoporosis has become an increasing problem in the majority of developed countries worldwide. The paper discusses the frequency, pathogenesis, diagnostic criteria and treatment options for osteoporosis in men. Every third hip fracture occurs in men, and more than 11 % of the male population over the age of 50 years suffer the fracture. Diagnostic tests for idiopathic osteoporosis are performed in men under 60 years of age without other potential risk factors of developing the disease. In the majority of cases, their low bone mineral density (BMD) is caused by a low peak bone mass. Secondary osteoporosis occurs in about 30 % of men, and involutionary osteoporosis developed in men over 60 years of age results from their decreased testosterone and IGF-1 levels. The study results showing that BMD levels in both sexes provide similar fracture risk information suggest that the existing diagnostic criteria for female osteoporosis can also be employed in men. It has been proved that biphosphonate and teriparitide therapy significantly increase BMD levels in men. The administration of androgens has been shown to be effective in men with hypogonadism, although their validity for patients with eugonadism has not yet been discussed. An improved knowledge of the bone metabolism and bone remodelling has recently opened the door to an extensive series of molecules that may play a key role in the treatment of male osteoporosis in the future
From functional food to medicinal product: Systematic approach in analysis of polyphenolics from propolis and wine
In the last decade we have been working on standardization of propolis extract and determination of active constituents of wine those are rich in polyphenolics and have nutritional as well as therapeutic value. Here we are summarizing our results and providing overview on systematic approach how to analyse natural products rich in flavonoids and phenolic acids
- ā¦