Analysis of B-> \phi K Decays in QCD Factorization

We analyze the decay $B\to \phi K$ within the framework of QCD-improved factorization. We found that although the twist-3 kaon distribution amplitude dominates the spectator interactions, it will suppress the decay rates slightly. The weak annihilation diagrams induced by $(S-P)(S+P)$ penguin operators, which are formally power-suppressed by order $(\Lambda/m_b)^2$, are chirally and logarithmically enhanced. Therefore, these annihilation contributions are not subject to helicity suppression and can be sizable. The predicted branching ratio of $B^-\to\phi K^-$ is $(3.8\pm0.6)\times 10^{-6}$ in the absence of annihilation contributions and it becomes $(4.3^{+3.0}_{-1.4})\times 10^{-6}$ when annihilation effects are taken into account. The prediction is consistent with CLEO and BaBar data but smaller than the BELLE result.Comment: 13 pages, 3 figures. A major change for the presentation of branching-ratio predictions. Experimental data are update

Indications for Factorization and ReVub<0Re V_{ub} < 0 from Rare B Decay Data

Surveying known hadronic rare B decays, we find that the factorization approximation can give a coherent account of $K\pi$, $\pi\pi$ and $\rho^0\pi^+$ data and give predictions for $\omega^0\pi^+$, $\rho\pi$ and $K^*\pi$ modes, {\it if ${Re}V_{ub}$ is taken as negative} (in standard phase convention) rather than positive. As further confirmation, we expect a lower $\sin2\beta$ value at B Factories as compared to current fits, and $B_s$ mixing close to LEP bounds at SLD and CDF.Comment: 11 pages, revtex, 4 figures (unchanged and eps files included); version (including title and abstract change) to appear in Phys. Rev. Let

Phenomenological Analysis of D Meson Lifetimes

The QCD-based operator-product-expansion technique is systematically applied to the study of charmed meson lifetimes. We stress that it is crucial to take into account the momentum of the spectator light quark of charmed mesons, otherwise the destructive Pauli-interference effect in $D^+$ decays will lead to a negative decay width for the $D^+$. We have applied the QCD sum rule approach to estimate the hadronic matrix elements of color-singlet and color-octet 4-quark operators relevant to nonleptonic inclusive $D$ decays. The lifetime of $D_s^+$ is found to be longer than that of $D^0$ because the latter receives a constructive $W$-exchange contribution, whereas the hadronic annihilation and leptonic contributions to the former are compensated by the Pauli interference. We obtain the lifetime ratio $\tau(D_s^+)/\tau(D^0)$ $\approx 1.08\pm 0.04$, which is larger than some earlier theoretical estimates, but still smaller than the recent measurements by CLEO and E791.Comment: 14 pages, 3 figure

Spin Dynamics of the Magnetoresistive Pyrochlore Tl_2Mn_2O_7

Neutron scattering has been used to study the magnetic order and spin dynamics of the colossal magnetoresistive pyrochlore Tl_2Mn_2O_7. On cooling from the paramagnetic state, magnetic correlations develop and appear to diverge at T_C (123 K). In the ferromagnetic phase well defined spin waves are observed, with a gapless ($\Delta <0.04$ meV) dispersion relation E=Dq^{2} as expected for an ideal isotropic ferromagnet. As T approaches T_C from low T, the spin waves renormalize, but no significant central diffusive component to the fluctuation spectrum is observed in stark contrast to the La$_{1-x}$(Ca,Ba,Sr)$_x$MnO$_3$ system. These results argue strongly that the mechanism responsible for the magnetoresistive effect has a different origin in these two classes of materials.Comment: 4 pages (RevTex), 4 figures (encapsulated postscript), to be published in Phys. Rev. Let

Tree-Penguin Interference and Tests for cos⁡γ<0\cos\gamma < 0 in Rare B→PPB\to PP, PVPV and VVVV Decays

Recent rare $B \to PP$, $PV$ decay data suggest that factorization holds well if, contrary to current fits, one has $\cos\gamma < 0$ where $\gamma \equiv {\rm arg}(V_{ub}^*)$. We update previous results with light cone sum rule form factors, which seem to work better. We then discuss various $B\to VV$ modes as well as the $K^{*} \eta$ modes. Finding the pattern of $\rho^+\omega^0 < \rho^+\rho^0$, $K^{*+}\rho^{-,0} > K^{*0}\rho^+$, $K^{*+}\omega^0 > K^{*0}\omega^0$ and $K^{*+}\eta > K^{*0}\eta$ would strengthen the support for $\cos\gamma < 0$. The electroweak penguin enhances (suppresses) the $K^{*+}\rho^{0}$ ($K^{*0}\rho^{0}$) rate by a factor of 2, and finding $K^{*+}\rho^{0} \simeq K^{*+}\rho^{-}$ would be strong evidence for the electroweak penguin.Comment: 22 pages, Latex, 14 eps figures include

Nonspectator Effects and B Meson Lifetimes from a Field-theoretic Calculation

The B meson lifetime ratios are calculated to the order of $1/m_b^3$ in the heavy quark expansion. The predictions of those ratios are dependent on four unknown hadronic parameters $B_1$, $B_2$, $\epsilon_1$ and $\epsilon_2$, where $B_1$ and $B_2$ parametrize the matrix elements of color singlet-singlet four-quark operators and $\epsilon_1$ and $\epsilon_2$ the matrix elements of color octet-octet operators. We derive the renormalization-group improved QCD sum rules for these parameters within the framework of heavy quark effective theory. The results are $B_1(m_b)=0.96\pm 0.04$, $B_2(m_b)=0.95\pm 0.02$, $\epsilon_1(m_b)=-0.14\pm 0.01$, and $\epsilon_2(m_b)=-0.08\pm 0.01$ to zeroth order in $1/m_b$. The resultant $B$ meson lifetime ratios are $\tau(B^-)/\tau(B_d)=1.11\pm 0.02$ and $\tau(B_s)/\tau(B_d)\approx 1$ in SU(3) symmetry limit.Comment: 22 pages, 2 figures. (i) Sec.II is shortened, (ii) numerical results for epslion_i are revised, and (iii) Fig.2 is revise

Key role for ubiquitin protein modification in TGFβ signal transduction

The transforming growth factor β (TGFβ) superfamily of signal transduction molecules plays crucial roles in the regulation of cell behavior. TGFβ regulates gene transcription through Smad proteins and signals via non-Smad pathways. The TGFβ pathway is strictly regulated, and perturbations lead to tumorigenesis. Several pathway components are known to be targeted for proteasomal degradation via ubiquitination by E3 ligases. Smurfs are well known negative regulators of TGFβ, which function as E3 ligases recruited by adaptors such as I-Smads. TGFβ signaling can also be enhanced by E3 ligases, such as Arkadia, that target repressors for degradation. It is becoming clear that E3 ligases often target multiple pathways, thereby acting as mediators of signaling cross-talk. Regulation via ubiquitination involves a complex network of E3 ligases, adaptor proteins, and deubiquitinating enzymes (DUBs), the last-mentioned acting by removing ubiquitin from its targets. Interestingly, also non-degradative ubiquitin modifications are known to play important roles in TGFβ signaling. Ubiquitin modifications thus play a key role in TGFβ signal transduction, and in this review we provide an overview of known players, focusing on recent advances

Accurate molecular classification of cancer using simple rules

<p>Abstract</p> <p>Background</p> <p>One intractable problem with using microarray data analysis for cancer classification is how to reduce the extremely high-dimensionality gene feature data to remove the effects of noise. Feature selection is often used to address this problem by selecting informative genes from among thousands or tens of thousands of genes. However, most of the existing methods of microarray-based cancer classification utilize too many genes to achieve accurate classification, which often hampers the interpretability of the models. For a better understanding of the classification results, it is desirable to develop simpler rule-based models with as few marker genes as possible.</p> <p>Methods</p> <p>We screened a small number of informative single genes and gene pairs on the basis of their depended degrees proposed in rough sets. Applying the decision rules induced by the selected genes or gene pairs, we constructed cancer classifiers. We tested the efficacy of the classifiers by leave-one-out cross-validation (LOOCV) of training sets and classification of independent test sets.</p> <p>Results</p> <p>We applied our methods to five cancerous gene expression datasets: leukemia (acute lymphoblastic leukemia [ALL] vs. acute myeloid leukemia [AML]), lung cancer, prostate cancer, breast cancer, and leukemia (ALL vs. mixed-lineage leukemia [MLL] vs. AML). Accurate classification outcomes were obtained by utilizing just one or two genes. Some genes that correlated closely with the pathogenesis of relevant cancers were identified. In terms of both classification performance and algorithm simplicity, our approach outperformed or at least matched existing methods.</p> <p>Conclusion</p> <p>In cancerous gene expression datasets, a small number of genes, even one or two if selected correctly, is capable of achieving an ideal cancer classification effect. This finding also means that very simple rules may perform well for cancerous class prediction.</p