Dichlorodiphenyltrichloroethane specifically depletes dopaminergic neurons in primary cell culture

Toxicity of dichlorodiphenyltrichloroethane (DDT) to dopaminergic neurons in primary cell culture was investigated in the present study. Developing neurons from the substantia nigra of neonatal rats were cultured. After treatments with different concentrations of DDT (5-12.5 μM), specific cell death of tyrosine-hydroxylase-immunoreactive dopaminergic neurons was observed in the culture by flow cytometric analysis. More than 60% of dopaminergic neurons were depleted after treatments with 10 and 12.5 μM of DDT. In addition, significant reductions of intensity levels of tyrosine hydroxylase immunofluorescence were observed in dopaminergic neurons after DDT treatments even at low concentrations of DDT. The present findings indicate that dopaminergic neurons are more susceptible to DDT toxicity than other types of neurons in the primary cell culture. Moreover, it is shown that the synthesis of dopamine in dopaminergic neurons is also depressed. Previous studies have demonstrated that perinatal exposure of DDT causes neurons to be more susceptible to neurotoxic damages in later adult life. The present findings thus provide evidence that dopaminergic neurons that are undergoing growth and development are targets of DDT neurotoxic effects. Exposure to DDT from contaminated environments is therefore a potential risk of onset of Parkinson's disease. Copyright © 2003 S. Karger AG, Basel.published_or_final_versio

Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis

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Quality of life (QoL) in southern Chinese with systemic lupus erythematosus (SLE)

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Inviscid two dimensional vortex dynamics and a soliton expansion of the sinh-Poisson equation

The dynamics of inviscid, steady, two dimensional flows is examined for the case of a hyperbolic sine functional relation between the vorticity and the stream function. The 2-soliton solution of the sinh-Poisson equation with complex wavenumbers will reproduce the Mallier-Maslowe pattern, a row of counter-rotating vortices. A special 4-soliton solution is derived and the corresponding flow configuration is studied. By choosing special wavenumbers complex flows bounded by two rigid walls can result. A conjecture regarding the number of recirculation regions and the wavenumber of the soliton expansion is offered. The validity of the new solution is verified independently by direct differentiation with a computer algebra software. The circulation and the vorticity of these novel flow patterns are finite and are expressed in terms of well defined integrals. The questions of the linear stability and the nonlinear evolution of a finite amplitude disturbance of these steady vortices are left for future studies. © 1998 American Institute of Physics.published_or_final_versio

The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

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Visible photoluminescence in ZnO tetrapod and multipod structures

The investigation of the properties of ZnO tetrapod and multipod structures using scanning electron microscopy, X-ray diffraction, photoluminescence (PL) and electron paramagnetic resonance (EPR) spectroscopy was discussed. The ZnO samples were fabricated by heating a mixture of ZnO, GeO2 and graphite at 1100°C in order to modify the morphology of the fabricated structures. The room temperature of PL was measured by using a HeCd laser excitation source (325 nm). It was found that the green PL was due to transition between a shallow donor and deep acceptor in the absence of g ≈ 1.96 EPR signal and transition between the conduction band and deep acceptor in the absence of g ≈ 1.96 EPR signal.published_or_final_versio

Correlating hemodynamic changes and occlusion time after flow diverter treatment of bilateral large internal carotid artery aneurysms

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Dynamical studies of macroscopic superposition states: Phase engineering of controlled entangled number states of Bose-Einstein condensate in multiple wells

We provide a scheme for the generation of entangled number states of Bose-Einstein condensates in multiple wells with cyclic pairwise connectivity. The condensate ground state in a multiple well trap can self-evolve, when phase engineered with specific initial phase differences between the neighboring wells, to a macroscopic superposition state with controllable entanglement -- to multiple well generalization of double well NOON states. We demonstrate through numerical simulations the creation of entangled states in three and four wells and then explore the creation of "larger" entangled states where there are either a larger number of particles in each well or a larger number of wells. The type of entanglement produced as the particle numbers, or interaction strength, increases changes in a novel and initially unexpected manner.Comment: 13 pages, 14 figure