Probability of Causation for Lung Cancer After Exposure to Radon Progeny: A Comparison of Models and Data

The estimates of lung cancer risk due to the exposure to radon decay products are based on different data sets from underground mining and on different mathematical models that are used to fit the data. Diagrams of the excess relative rate per 100 working level months in its dependence on age at exposure and age attained are shown to be a useful tool to elucidate the influence that is due to the choice of the model, and to assess the differences between the data from the major western cohorts and those from the Czech uranium miners. It is seen that the influence of the choice of the model is minor compared to the difference between the data sets. The results are used to derive attributable lifetime risks and probabilities of causation for lung cancer following radon progeny exposures

A Survey of the Czechoslovak Follow-up of Lung Cancer Mortality in Uranium Miners

The major Czechoslovak cohort of uranium miners (S-cohort) is surveyed in terms of diagrams illustrating dependences on calendar year, age, and exposure to radon and radon progeny. An analysis of the dose dependence of lung cancer mortality is performed by nonparametric and, subsequently, by parametric methods. In the first step, two-dimensional isotonic regression is employed to derive the lung cancer mortality rate and the relative excess risk as functions of age attained and of lagged cumulated exposure. In a second step, analytical fits in terms of relative risk models are derived. The treatment is largely analogous to the methods applied by the BEIR IV Committee to other major cohorts of uranium miners. There is a marked dependence of the excess risk on age attained and on time since exposure. A specific characteristic of the Czechoslovak data is the nonlinearity of the dependence of the lung cancer excess risk on the cumulated exposure; exposures on the order of 100 working level months or less appear to be more effective per working level month than larger exposures but, in the absence of an internal control group, this cannot be excluded to be due to confounders such as smoking or environmental exposures. A further notable observation is the association of larger excess risks with longer protraction of the exposures

High Current Diffusion Type Diodes at Cryogenic Temperatures for the LHC Superconducting Magnet Protection

High-current by-pass diodes are required for the protection of the superconducting magnets for the Large Hadron Collider LHC at CERN . These diodes are at liquid helium tem-perature and will be exposed to irradiation. With the re-location of the by-pass diodes for the main dipoles underneath the iron yoke and of those for the quadrupoles at the bottom of the cryostat the new estimations for the irradiation dose amounts to about 30 Gy and a neutron fluence of about 1.5 x 1011 n/cm2 for the dipole di-odes and about 100 Gy and5 x 1011 n/cm2 for the quadrupole diodes during 10 years. These relatively low doses may allow the use of diffusion type diodes in-stead of epitaxial diodes. The electrical characteristics of several diodes were measured at temperatures in the range between 1.8K and 300K. Diffu-sion type diodes from three manufacturers were submitted to high current endurance tests in liquid helium. Electrical characteristics and temperatures were measured versus time and showed acceptable results. First irradiation tests show that modified diffusion diodes can be used at least for the dipole by-pass

The Sphaleron Barrier in the Presence of Fermions

We calculate the minimal energy path over the sphaleron barrier in the pre\-sen\-ce of fermions, assuming that the fermions of a doublet are degenerate in mass. This allows for spherically symmetric ans\"atze for the fields, when the mixing angle dependence is neglected. While light fermions have little influence on the barrier, the presence of heavy fermions ($M_F \sim$ TeV) strongly deforms the barrier, giving rise to additional sphalerons for very heavy fermions ($M_F \sim$ 10 TeV). Heavy fermions form non-topological solitons in the vacuum sector.Comment: 19 pages, latex, 18 figures in 3 seperate uuencoded postscript files THU-93/1

Level Crossing Along Sphaleron Barriers

In the electroweak sector of the standard model topologically inequivalent vacua are separated by finite energy barriers, whose height is given by the sphale\-ron. For large values of the Higgs mass there exist several sphaleron solutions and the barriers are no longer symmetric. We construct paths of classical configurations from one vacuum to a neighbouring one and solve the fermion equations in the background field configurations along such paths, choosing the fermions of a doublet degenerate in mass. As in the case of light Higgs masses we observe the level crossing phenomenon also for large Higgs masses.Comment: 17 pages, latex, 10 figures in uuencoded postscript files. THU-94/0

Metal nanofilm in strong ultrafast optical fields

We predict that a metal nanofilm subjected to an ultrashort (single oscillation) optical pulse of a high field amplitude $\sim 3 \mathrm{V/\AA}$ at normal incidence undergoes an ultrafast (at subcycle times $\lesssim 1 \mathrm{fs}$) transition to a state resembling semimetal. Its reflectivity is greatly reduced, while the transmissivity and the optical field inside the metal are greatly increased. The temporal profiles of the optical fields are predicted to exhibit pronounced subcycle oscillations, which are attributed to the Bloch oscillations and formation of the Wannier-Stark ladder of electronic states. The reflected, transmitted, and inside-the-metal pulses have non-zero areas approaching half-cycle pulses. The effects predicted are promising for applications to nanoplasmonic modulators and field-effect transistors with petahertz bandwidth

In vitro assay for antimicrobial interaction evaluation and risk assessment of antimicrobials in anaerobic digestion of swine manure.

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