Impurity emission characteristics of long pulse discharges in Large Helical Device

Line spectra from intrinsic impurity ions have been monitored during the three kinds of long-pulse discharges (ICH, ECH, NBI). Constant emission from the iron impurity shows no preferential accumulation of iron ion during the long-pulse operations. Stable Doppler ion temperature has been also measured from Fe XX, C V and C III spectra

ケッカクキンスイヨウセイアジュバント

京都大学0048新制・論文博士医学博士乙第3660号論医博第753号新制||医||247(附属図書館)5671UT51-53-M192(主査)教授 伊藤 洋平, 教授 桂 義元, 教授 安平 公夫学位規則第5条第2項該当Kyoto UniversityDA

MODE OF ACTION OF A MYCOBACTERIAL WATER-SOLUBLE ADJUVANT, MAF3

この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。The concomitant use of a mycobacterial water-soluble adjuvant, MAF3, at the time of immunization, enhanced anti-hapten antibody production in guinea pigs treated with either heterologous or homologous dinitrophenylated proteins. This may be due to stimulation by the adjuvant of B-cells and/or helper T-cells. The adjuvant activity of MAF3 in anti-hapten antibody production was seen in immunization with a T-independent antigen, DPN-dextran, although it appeared only when a large amount of the conjugated antigen was introduced as the immunizing antigen. Delayed hypersensitivity reactions which require the participation of effector T-cells were also increased by MAF3. When challenged with the same dinitrophenylated protein antigen as the immunizing antigen, the delayed reactions in the skin or cornea were much stronger in animals treated with the antigen plus adjuvant than in control immune animals. The enhancement was seen when T-dependent but not T-independent antigen was used together with the adjuvant at immunization. No delayed hypersensitivity reaction was demonstrated after immunization with DNP-dextran either with or without MAF3. Conjugates of DNP with MAF3 were immunogenic in the production of anti-DNP antibodies in guinea pigs. However, delayed skin reaction in the these animals were induced by challenging injections of the same conjugates as the immunizing antigen or MAF3, the carrier, but not of DNP-GAP, DNP-OA or DNP-Lys. Similar skin reactions were observed in guinea pigs immunized with MAF3 and challenged with the same antigen. Therefore, DNP-MAF3 is defective as a hapten-carrier antigen presumably because of insufficient substitution of antigenic sites of the carrier with the hapten