10,078 research outputs found
Designing fuzzy rule based classifier using self-organizing feature map for analysis of multispectral satellite images
We propose a novel scheme for designing fuzzy rule based classifier. An SOFM
based method is used for generating a set of prototypes which is used to
generate a set of fuzzy rules. Each rule represents a region in the feature
space that we call the context of the rule. The rules are tuned with respect to
their context. We justified that the reasoning scheme may be different in
different context leading to context sensitive inferencing. To realize context
sensitive inferencing we used a softmin operator with a tunable parameter. The
proposed scheme is tested on several multispectral satellite image data sets
and the performance is found to be much better than the results reported in the
literature.Comment: 23 pages, 7 figure
Signal Propagation in Feedforward Neuronal Networks with Unreliable Synapses
In this paper, we systematically investigate both the synfire propagation and
firing rate propagation in feedforward neuronal network coupled in an
all-to-all fashion. In contrast to most earlier work, where only reliable
synaptic connections are considered, we mainly examine the effects of
unreliable synapses on both types of neural activity propagation in this work.
We first study networks composed of purely excitatory neurons. Our results show
that both the successful transmission probability and excitatory synaptic
strength largely influence the propagation of these two types of neural
activities, and better tuning of these synaptic parameters makes the considered
network support stable signal propagation. It is also found that noise has
significant but different impacts on these two types of propagation. The
additive Gaussian white noise has the tendency to reduce the precision of the
synfire activity, whereas noise with appropriate intensity can enhance the
performance of firing rate propagation. Further simulations indicate that the
propagation dynamics of the considered neuronal network is not simply
determined by the average amount of received neurotransmitter for each neuron
in a time instant, but also largely influenced by the stochastic effect of
neurotransmitter release. Second, we compare our results with those obtained in
corresponding feedforward neuronal networks connected with reliable synapses
but in a random coupling fashion. We confirm that some differences can be
observed in these two different feedforward neuronal network models. Finally,
we study the signal propagation in feedforward neuronal networks consisting of
both excitatory and inhibitory neurons, and demonstrate that inhibition also
plays an important role in signal propagation in the considered networks.Comment: 33pages, 16 figures; Journal of Computational Neuroscience
(published
The Higgs as a Probe of Supersymmetric Extra Sectors
We present a general method for calculating the leading contributions to h ->
gg and h -> gamma gamma in models where the Higgs weakly mixes with a nearly
supersymmetric extra sector. Such mixing terms can play an important role in
raising the Higgs mass relative to the value expected in the MSSM. Our method
applies even when the extra sector is strongly coupled, and moreover does not
require a microscopic Lagrangian description. Using constraints from holomorphy
we fix the leading parametric form of the contributions to these Higgs
processes, including the Higgs mixing angle dependence, up to an overall
coefficient. Moreover, when the Higgs is the sole source of mass for a
superconformal sector, we show that even this coefficient is often calculable.
For appropriate mixing angles, the contribution of the extra states to h -> gg
and h -> gamma gamma can vanish. We also discuss how current experimental
limits already lead to non-trivial constraints on such models. Finally, we
provide examples of extra sectors which satisfy the requirements necessary to
use the holomorphic approximation.Comment: v4: 34 pages, 2 figures, typo corrected and clarification adde
Electroweak Symmetry Breaking in the DSSM
We study the theoretical and phenomenological consequences of modifying the
Kahler potential of the MSSM two Higgs doublet sector. Such modifications
naturally arise when the Higgs sector mixes with a quasi-hidden conformal
sector, as in some F-theory GUT models. In the Delta-deformed Supersymmetric
Standard Model (DSSM), the Higgs fields are operators with non-trivial scaling
dimension 1 < Delta < 2. The Kahler metric is singular at the origin of field
space due to the presence of quasi-hidden sector states which get their mass
from the Higgs vevs. The presence of these extra states leads to the fact that
even as Delta approaches 1, the DSSM does not reduce to the MSSM. In
particular, the Higgs can naturally be heavier than the W- and Z-bosons.
Perturbative gauge coupling unification, a large top quark Yukawa, and
consistency with precision electroweak can all be maintained for Delta close to
unity. Moreover, such values of Delta can naturally be obtained in
string-motivated constructions. The quasi-hidden sector generically contains
states charged under SU(5)_GUT as well as gauge singlets, leading to a rich,
albeit model-dependent, collider phenomenology.Comment: v3: 40 pages, 3 figures, references added, typos correcte
An ex vivo porcine spleen perfusion as a model of bacterial sepsis
An ex vivo, porcine spleen perfusion model was established to study the early events occurring in the spleen prior to
the onset of bacterial sepsis, using organs retrieved from animals slaughtered for food production. Porcine spleens
were harvested from adult pigs and connected to a normothermic extracorporeal perfusion circuit. Constant perfusion
of heparinized blood was performed for 6 hours. After injection of Streptococcus pneumoniae to the circuit, serial
samples of both blood and spleen biopsies were collected and analyzed. Functionality of the perfused organs was
assessed by monitoring the blood-gas parameters, flow rate and filtering capability of the organ. Interestingly, we
observed full clearance of bacteria from the blood and an increase in bacterial counts in the spleen. Classical histology
and immunohistochemistry on biopsies also confirmed no major damage in the organ architecture and no changes in
the immune cell distribution other than the presence of clusters of pneumococci. A time-course study confirmed that each
focus of infection derived from the replication of single pneumococcal cells within splenic macrophages. The model
proposed – in line with the 3Rs principles – has utility in the replacement of experimental animals in infection research.
Murine models are prevalently used to study pneumococcal infections but are often not predictive for humans due to
substantial differences in the immune systems of the two species. This model is designed to overcome these limitations,
since porcine immunology, and splenic architecture in particular, closely resemble those of humans
The Architectural Design Rules of Solar Systems based on the New Perspective
On the basis of the Lunar Laser Ranging Data released by NASA on the Silver
Jubilee Celebration of Man Landing on Moon on 21st July 1969-1994, theoretical
formulation of Earth-Moon tidal interaction was carried out and Planetary
Satellite Dynamics was established. It was found that this mathematical
analysis could as well be applied to Star and Planets system and since every
star could potentially contain an extra-solar system, hence we have a large
ensemble of exoplanets to test our new perspective on the birth and evolution
of solar systems. Till date 403 exoplanets have been discovered in 390
extra-solar systems. I have taken 12 single planet systems, 4 Brown Dwarf -
Star systems and 2 Brown Dwarf pairs. Following architectural design rules are
corroborated through this study of exoplanets. All planets are born at inner
Clarke Orbit what we refer to as inner geo-synchronous orbit in case of
Earth-Moon System. By any perturbative force such as cosmic particles or
radiation pressure, the planet gets tipped long of aG1 or short of aG1. Here
aG1 is inner Clarke Orbit. The exoplanet can either be launched on death spiral
as CLOSE HOT JUPITERS or can be launched on an expanding spiral path as the
planets in our Solar System are. It was also found that if the exo-planet are
significant fraction of the host star then those exo-planets rapidly migrate
from aG1 to aG2 and have very short Time Constant of Evolution as Brown Dwarfs
have. This vindicates our basic premise that planets are always born at inner
Clarke Orbit. This study vindicates the design rules which had been postulated
at 35th COSPAR Scientific Assembly in 2004 at Paris, France, under the title
,New Perspective on the Birth & Evolution of Solar Systems.Comment: This paper has been reported to Earth,Moon and Planets Journal as
MOON-S-09-0007
Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM)
We present a high content multiwell plate cell-based assay approach to quantify protein interactions directly in cells using Förster resonance energy transfer (FRET) read out by automated fluorescence lifetime imaging (FLIM). Automated FLIM is implemented using wide-field time-gated detection, typically requiring only 10 s per field of view (FOV). Averaging over biological, thermal and shot noise with 100's to 1000's of FOV enables unbiased quantitative analysis with high statistical power. Plotting average donor lifetime vs. acceptor/donor intensity ratio clearly identifies protein interactions and fitting to double exponential donor decay models provides estimates of interacting population fractions that, with calibrated donor and acceptor fluorescence intensities, can yield dissociation constants. We demonstrate the application to identify binding partners of MST1 kinase and estimate interaction strength among the members of the RASSF protein family, which have important roles in apoptosis via the Hippo signalling pathway. KD values broadly agree with published biochemical measurements
Population genomic analysis of mango (Mangifera indica) suggests a complex history of domestication
Trust Humans have domesticated diverse species from across the plant kingdom, yet much of our foundational knowledge of domestication has come from studies investigating relatively few of the most important annual food crops. Here, we examine the impacts of domestication on genetic diversity in a tropical perennial fruit species, mango (Mangifera indica). We used restriction site associated DNA sequencing to generate genomic single nucleotide polymorphism (SNP) data from 106 mango cultivars from seven geographical regions along with 52 samples of closely related species and unidentified cultivars to identify centers of mango genetic diversity and examine how post-domestication dispersal shaped the geographical distribution of diversity. We identify two gene pools of cultivated mango, representing Indian and Southeast Asian germplasm. We found no significant genetic bottleneck associated with the introduction of mango into new regions of the world. By contrast, we show that mango populations in introduced regions have elevated levels of diversity. Our results suggest that mango has a more complex history of domestication than previously supposed, perhaps including multiple domestication events, hybridization and regional selection. Our work has direct implications for mango breeding and genebank management, and also builds on recent efforts to understand how woody perennial crops respond to domestication
A model for reactive porous transport during re-wetting of hardened concrete
A mathematical model is developed that captures the transport of liquid water
in hardened concrete, as well as the chemical reactions that occur between the
imbibed water and the residual calcium silicate compounds residing in the
porous concrete matrix. The main hypothesis in this model is that the reaction
product -- calcium silicate hydrate gel -- clogs the pores within the concrete
thereby hindering water transport. Numerical simulations are employed to
determine the sensitivity of the model solution to changes in various physical
parameters, and compare to experimental results available in the literature.Comment: 30 page
Is population structure sufficient to generate area-level inequalities in influenza rates? An examination using agent-based models
Background: In New Haven County, CT (NHC), influenza hospitalization rates have been shown to increase with census tract poverty in multiple influenza seasons. Though multiple factors have been hypothesized to cause these inequalities, including population structure, differential vaccine uptake, and differential access to healthcare, the impact of each in generating observed inequalities remains unknown. We can design interventions targeting factors with the greatest explanatory power if we quantify the proportion of observed inequalities that hypothesized factors are able to generate. Here, we ask if population structure is sufficient to generate the observed area-level inequalities in NHC. To our knowledge, this is the first use of simulation models to examine the causes of differential poverty-related influenza rates. Methods: Using agent-based models with a census-informed, realistic representation of household size, age-structure, population density in NHC census tracts, and contact rates in workplaces, schools, households, and neighborhoods, we measured poverty-related differential influenza attack rates over the course of an epidemic with a 23 % overall clinical attack rate. We examined the role of asthma prevalence rates as well as individual contact rates and infection susceptibility in generating observed area-level influenza inequalities. Results: Simulated attack rates (AR) among adults increased with census tract poverty level (F = 30.5; P < 0.001) in an epidemic caused by a virus similar to A (H1N1) pdm09. We detected a steeper, earlier influenza rate increase in high-poverty census tracts - a finding that we corroborate with a temporal analysis of NHC surveillance data during the 2009 H1N1 pandemic. The ratio of the simulated adult AR in the highest- to lowest-poverty tracts was 33 % of the ratio observed in surveillance data. Increasing individual contact rates in the neighborhood did not increase simulated area-level inequalities. When we modified individual susceptibility such that it was inversely proportional to household income, inequalities in AR between high- and low-poverty census tracts were comparable to those observed in reality. Discussion: To our knowledge, this is the first study to use simulations to probe the causes of observed inequalities in influenza disease patterns. Knowledge of the causes and their relative explanatory power will allow us to design interventions that have the greatest impact on reducing inequalities. Conclusion: Differential exposure due to population structure in our realistic simulation model explains a third of the observed inequality. Differential susceptibility to disease due to prevailing chronic conditions, vaccine uptake, and smoking should be considered in future models in order to quantify the role of additional factors in generating influenza inequalities
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