The influence of drug solubility and sampling frequency on metformin and glibenclamide release from double-layered particles: experimental analysis and mathematical modelling

Co-axial electrohydrodynamic atomization was used to prepare core/shell polymethylsilsesquioxane particles for co-delivery of metformin and glibenclamide in a sustained release manner. The drug-loaded microparticles were mostly spherical and uniformly distributed in size, with average diameters between 3 and 5 µm across various batches. FTIR was used to confirm the presence of drugs within the particles while X-ray diffraction studies revealed drugs encapsulated existed predominantly in the amorphous state. Intended as systems that potentially can act as depot formulations for long-term release of antidiabetics, a detailed analysis of drug release from these particles was necessary. Drugs of different solubilities were selected in order to study the effects of drug solubility from a core/shell particle system. Further analyses to determine how conditions such as release into a limited volume of media, sampling rate and partitioning of drug between the core and shell layers influenced drug release were conducted by comparing experimental and mathematically modelled outcomes. It was found that while the solubility of drug may affect release from such systems, rate of removal of drug (sampling frequency) which upsets local equilibrium at the particle/solution interface prompting a rapid release to redress the equilibrium influenced release more

Adolescents’ Perceptions of the Psychological Distance to Climate Change, Its Relevance for Building Concern About It, and the Potential for Education

One of the greatest challenges of this century is climate change. Unfortunately, it is still unclear how to motivate people to engage in environmentally friendly behaviour. To be effective, education and communication strategies must take into account people’s perceptions and beliefs. A root difficulty is that the general public tends to perceive climate change as a psychologically distant phenomenon—something that, if at all, happens not here, not now, and not to oneself. In this study, we explored perceptions of psychological distance to climate change with a highly relevant but so far overlooked population—adolescents. Swiss adolescents (N = 587) perceived climate change to be a certain and present risk. However, they perceived climate change to affect other places and other people more than themselves. Regression analysis revealed a significant inverse relationship between distance and concern: respondents who felt psychologically closer to the phenomenon expressed greater concern. The findings contribute to the understanding of how young people perceive climate change, which should assist in designing education strategies to make it more salient for individual behaviour

How rats perform spatial working memory tasks: Limitations in the use of egocentric and idiothetic working memory

Rats of the Dark Agouti strain were trained on delayed alternation under conditions that should encourage egocentric working memory. In two experiments a T-maze was set within a cross-maze so that different arms could be used for the sample and test runs. The maze had high opaque side-walls, and testing was conducted in low light levels so that distal visual cues might be eliminated. By rotating the maze 90° between the sample and choice run and by using two identical mazes set side by side it was possible to nullify other spatial strategies. Experiments 1 and 2 showed that rats preferentially used place information, intramaze cues, and direction cues, even though only egocentric or idiothetic (nonmatch-to-turn) working memory could successfully solve every trial. Rats were able to maintain an accurate sense of location within the maze even though distal cues were not visible and the animal was moved between the sample and choice runs. Experiment 2 confirmed that another rat strain (Long-Evans) shows the same learning profiles. Both experiments indicate that rats are very poor at using either egocentric or idiothetic information to alternate, and that retention delays as short as 10 s can eliminate the use of these forms of memory