16 research outputs found
Immunoregulatory dysfunctions in type I diabetes: Natural and antibody-dependent cellular cytotoxic activities
Peripheral blood lymphocytes from 13 patients with established insulin-dependent diabetes mellitus (IDDM) and 2 prediabetic patients were examined for natural killer (NK) and antibody-dependent cellular cytotoxic activities (ADCC), lectin-dependent cellular cytotoxicity (LDCC), interferon- and interleukin-2-induced cytotoxicity, and concanavalin A-induced suppressor-cell activities in comparison with age-matched normal controls. IDDM patients demonstrated normal levels of NK and ADCC activities against K562 and antibody-coated SB target cells, respectively, compared to controls. IDDM patients showed normal levels of LDCC activity. Notable deviations from control values were, however, observed with diabetic lymphocytes in the following systems. Interferon-and interleukin-2-induced NK activities were significantly higher with IDDM lymphocytes than with control cells. IDDM lymphocytes precultured with concanavalin A demonstrated lower NK and ADCC activities than control cells and manifested decreased suppressor effects on the NK activity of normal allogeneic lymphocytes. Lymphocytes from one of two prediabetic patients showed increased NK, ADCC, and LDCC activities in comparison to controls. The increased interferon- and interleukin-2-induced enhancement of NK activity and reduced suppressor activity of lymphocytes from IDDM patients may be involved in the pathogenesis of the disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44848/1/10875_2004_Article_BF00915375.pd
Natural killer cell and islet killer cell activities in Type 1 (insulin-dependent) diabetes
Large granular lymphocytes: Morphological and functional properties I. Results in normals
IL-2 gene therapy of solid tumors: an approach for the prevention of signal transduction defects in T cells
Polymorphic variant at the IL2 region is associated with type 1 diabetes and may affect serum levels of interleukin-2
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
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