Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Additional file 3: Figure S3. Regulation of genes of Arrhythmogenic right ventricular cardiomyopathy pathway during senescence induction in HFF strains Genes of the “Arrhythmogenic right ventricular cardiomyopathy” pathway which are significantly up- (green) and down- (red) regulated (log2 fold change >1) during irradiation induced senescence (120 h after 20 Gy irradiation) in HFF strains. Orange color signifies genes which are commonly up-regulated during both, irradiation induced and replicative senescence

On the Tropical Origins of the Alps

A remarkable colonial encounter took place on 26 February 1896 on the south-eastern peninsula of Celebes — one of the many so-called outer islands in the far-flung Dutch Asian Empire. Two wealthy Swiss naturalists, Paul and Fritz Sarasin, the first Europeans to explore this large hitherto ‘unknown’ island, reached the summit of one of the mountains in the highlands. At 1000 metres above sea level they were rewarded with a surprising view. A large lake ‘gleaming in magnificent blue’ lay before them. ‘Delighted by this discovery we hurried down to the lakeside where yet another surprise awaited us. A real, inhabited village with houses built on piles arose from the water, a village named Matanna.’1 The Sarasins’ excitement grew even further as they found out that the lake dwellers on Celebes ‘practised a curious form of pottery with products reminding us of identical objects from Swiss lake dwellers’.2 It is important to note the asymmetry of this comparison. The Sarasins were not referring to contemporary Swiss lake dwellers. In fact there were no people living in lakes in Switzerland around 1900. The reference was to prehistoric lake dwellers, whose poles and material remains Swiss archaeologists had started digging up from the mud of the lakeshores a few decades earlier. What the Sarasins thought they had discovered on the shores of Lake Matanna was thus a piece of living prehistory on a tropical island which, to them, in many ways resembled Switzerland