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Single left superior vena cava antenatal diagnosis, associations and outcomes
Objectives
To describe the associated cardiac and extracardiac findings and estimate the prevalence of single left superior vena cava (LSVC) among fetuses referred for fetal echocardiography.
Methods
This is a retrospective case series study of fetuses diagnosed with situs solitus and single LSVC at the Brompton Centre for Fetal Cardiology, from October 2006 to December 2020. Prenatal and postnatal outcome data were collected. Prenatal diagnosis was based on abnormal vessel alignment at the 3-vessel view (3VV) and/or 3-vessel and trachea view (3VT), showing a vessel to the left of the pulmonary artery, the LSVC, and absence of the usual vessel to the right of the ascending aorta, the right superior vena cava (RSVC), and further visualisation of the LSVC draining to the coronary sinus.
Results
Amongst 19,968 fetal echocardiograms, 34 cases were identified (prevalence 0.17%). There were 32 livebirths, 1 lost to follow up and one fetal demise. Single LSVC was isolated in most cases. No major CHD was identified. One fetus showed mild isthmus hypoplasia, with no aortic coarctation postnatally. Two fetuses had umbilical vessel abnormalities. Genetic abnormality was found in one case.
Conclusions
Antenatal diagnosis of single LSVC in situs solitus is usually a benign isolated finding. Nevertheless, investigation of other cardiac, extracardiac and genetic disorders should be considered
Monoclonality of asynchronous bilateral lymphoma of the testis
Objectives: Lymphoma is the most frequent testicular malignancy in men over 60 years of age. Even though patients present initially with localized disease, the high incidence of bilateral involvement, synchronous or not, and early systemic dissemination are characteristic of these neoplasms. Sometimes the interval between tumor involvement of both testes is long. the question is raised whether either the patient has a predisposition to present new clones of transformed lymphocytes, or the same disease using the same pathway from a systemic reservoir infiltrates the contralateral testis.Method: Polymerase chain reaction and DNA sequencing were used to detect immunoglobulin heavy chain (IgH) rearrangement in paraffin-embedded specimens from asynchronous tumors affecting the right and left testis of a 85-year-old man with an interval period of 13 months.Results: Both tumors showed the same IgH rearrangement.Conclusions.. the lymphoma affecting the left and right testis derived from the same clone. It makes a strong case that lymphoma of the testis is the first manifestation of a systemic disease and should be treated aggressively early at the beginning of the disease. Copyright (C) 2000 S. Karger AG. Basel.Sirio Libanes Hosp, Lab Mol & Surg Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Div Urol, São Paulo, BrazilHosp A C Camargo, Lab Pathol Clin & Hemoterapia, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Div Urol, São Paulo, BrazilWeb of Scienc