2,431 research outputs found
213 Progression of pulmonary hyperinflation and trapped gas associated with genetic factors in children with cystic fibrosis (CF)
Effects of Physical Conditioning on Intercollegiate Golfer Performance
This investigation was conducted to determine the effects of a physical conditioning program on clubhead speed, consistency, and putting distance control in 10 men and 6 women National Collegiate Athletic Association Division I golfers. Supervised strength, power, and flexibility training was performed 3 times per week for 11 weeks. Performance tests were conducted before and after the training period. Significant (p \u3c 0.05) increases were noted for all strength, power, and flexibility tests from pre- to posttraining of between 7.3 and 19.9%. Clubhead speed in- creased significantly (1.6%), equating to approximately a 4.9-m increase in driving distance. Putting distance control significantly improved for the men-only group (29.6%), whereas there was no significant difference in putting distance control for the total and women-only groups. Eleven weeks of golf-specific physical conditioning increased clubhead speed without a negative effect on consistency or putting distance control in intercollegiate men and women golfers
Long-term gas exchange characteristics as marker of deterioration in patients with cystic fibrosis
Background and Aim
In patients with cystic fibrosis (CF) the architecture of the developing lungs and the ventilation of lung units are progressively affected, influencing intrapulmonary gas mixing and gas exchange. We examined the long-term course of blood gas measurements in relation to characteristics of lung function and the influence of different CFTR genotype upon this process.
Methods
Serial annual measurements of PaO2 and PaCO2 assessed in relation to lung function, providing functional residual capacity (FRCpleth), lung clearance index (LCI), trapped gas (VTG), airway resistance (sReff), and forced expiratory indices (FEV1, FEF50), were collected in 178 children (88 males; 90 females) with CF, over an age range of 5 to 18 years. Linear mixed model analysis and binary logistic regression analysis were used to define predominant lung function parameters influencing oxygenation and carbon dioxide elimination.
Results
PaO2 decreased linearly from age 5 to 18 years, and was mainly associated with FRCpleth, (p < 0.0001), FEV1 (p < 0.001), FEF50 (p < 0.002), and LCI (p < 0.002), indicating that oxygenation was associated with the degree of pulmonary hyperinflation, ventilation inhomogeneities and impeded airway function. PaCO2 showed a transitory phase of low PaCO2 values, mainly during the age range of 5 to 12 years. Both PaO2 and PaCO2 presented with different progression slopes within specific CFTR genotypes.
Conclusion
In the long-term evaluation of gas exchange characteristics, an association with different lung function patterns was found and was closely related to specific genotypes. Early examination of blood gases may reveal hypocarbia, presumably reflecting compensatory mechanisms to improve oxygenation
Endogenous social distancing and its underappreciated impact on the epidemic curve
Social distancing is an effective strategy to mitigate the impact of infectious diseases. If sick or healthy, or both, predominantly socially distance, the epidemic curve flattens. Contact reductions may occur for different reasons during a pandemic including health-related mobility loss (severity of symptoms), duty of care for a member of a high-risk group, and forced quarantine. Other decisions to reduce contacts are of a more voluntary nature. In particular, sick people reduce contacts consciously to avoid infecting others, and healthy individuals reduce contacts in order to stay healthy. We use game theory to formalize the interaction of voluntary social distancing in a partially infected population. This improves the behavioral micro-foundations of epidemiological models, and predicts differential social distancing rates dependent on health status. The model’s key predictions in terms of comparative statics are derived, which concern changes and interactions between social distancing behaviors of sick and healthy. We fit the relevant parameters for endogenous social distancing to an epidemiological model with evidence from influenza waves to provide a benchmark for an epidemic curve with endogenous social distancing. Our results suggest that spreading similar in peak and case numbers to what partial immobilization of the population produces, yet quicker to pass, could occur endogenously. Going forward, eventual social distancing orders and lockdown policies should be benchmarked against more realistic epidemic models that take endogenous social distancing into account, rather than be driven by static, and therefore unrealistic, estimates for social mixing that intrinsically overestimate spreading
A new fossil inchworm moth discovered in Miocene Dominican amber (Lepidoptera : Geometridae)
Unidad de excelencia María de Maeztu CEX2019-000940-MWe report a fossil geometrid moth, a male, virtually complete, preserved in a clear piece of Miocene Dominican amber dating from 19 to 16 Mya. Fore- and hindwings appear partially overlapped, and all body characters are visible externally in dorsal and ventral views, including the outer surface of the valvae of the genitalia. The scale pattern on the wing membrane is preserved, whereas the wing color pattern is not. It belongs to the genus Dolichoneura (Geometridae: Desmobathrinae) and is named Dolichoneura jorelisae Sarto i Monteys, Hausmann, Baixeras and Peñalver sp. n., based on wing features. Because of the poor fossil record of lepidopterans, both in amber and compression rocks, the description of the available well-preserved specimens is of considerable interest for phylogenetic studies. Furthermore, it could also serve for calibrating molecular clocks and for paleobiogeographic inferences
Exercise medicine for cancer cachexia: Targeted exercise to counteract mechanisms and treatment side-effects
Purpose: Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most optimal form and dosage of exercise therapy specific to each underlying mechanism of CC. Methods: The relevant literatures from MEDLINE and Scopus databases were examined. Results: Exercise can counteract the most prominent mechanisms and signs of CC including muscle wasting, increased protein turnover, systemic inflammation, reduced appetite and anorexia, increased energy expenditure and fat wasting, insulin resistance, metabolic dysregulation, gut dysbiosis, hypogonadism, impaired oxidative capacity, mitochondrial dysfunction, and cancer treatments side-effects. There are different modes of exercise, and each mode has different sub-types that induce vastly diverse changes when performed over multiple sessions. Choosing suboptimal exercise modes, types, or dosages can be counterproductive and could further contribute to the mechanisms of CC without impacting muscle growth. Conclusion: Available evidence shows that patients with CC can safely undertake higher-intensity resistance exercise programs, and benefit from increases in body mass and muscle mass
A Dissection of Spatially Resolved AGN Feedback across the Electromagnetic Spectrum
We present optical SuperNova Integral Field Spectrograph integral field spectroscopy, Hubble Space Telescope optical imaging, Chandra X-ray imaging, and Very Large Array radio interferometry of the merging galaxy 2MASX J04234080+0408017, which hosts a Seyfert 2 active galactic nucleus (AGN) at z = 0.046. Our observations reveal that radiatively driven, ionized gas outflows are successful to distances >10 kpc due to the low mass of the host system, encompassing the entirety of the observed optical emission. We also find that at large radii, where observed velocities cannot be reproduced by radiative driving models, high-velocity kinematics are likely due to mechanical driving from AGN winds impacting high-density host material. This impacting deposits sufficient energy to shock the host material, producing thermal X-ray emission and cosmic rays, which in turn promote the formation of in situ radio structure in a pseudo-jet morphology along the high-density lanes
Drivers and impact of the early silent invasion of SARS-CoV-2 Alpha
SARS-CoV-2 variants of concern (VOCs) circulated cryptically before being identified as a threat, delaying interventions. Here we studied the drivers of such silent spread and its epidemic impact to inform future response planning. We focused on Alpha spread out of the UK. We integrated spatio-temporal records of international mobility, local epidemic growth and genomic surveillance into a Bayesian framework to reconstruct the first three months after Alpha emergence. We found that silent circulation lasted from days to months and decreased with the logarithm of sequencing coverage. Social restrictions in some countries likely delayed the establishment of local transmission, mitigating the negative consequences of late detection. Revisiting the initial spread of Alpha supports local mitigation at the destination in case of emerging events
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