Breast Cancer Related Lymphedema and Conservative Therapies

WOS: 000269581400007Lymphedema is characterized by generalized or regional accumulation of protein-rich interstitial fluid that occurs as a consequence of congenital or acquired disruption of lymphatic circulation. Cancer-related lymphedema is the most common cause of secondary upper and lower extremity lymphedema. Secondary arm lymphedema is a chronic and disabling condition which affects a significant number of women who undergo breast cancer treatment. The incidence of breast cancer-related lymphedema was reported to be between 2.4 to 56%. Extensive surgical nodal clearing and irradiation are the most important risk factors for the development of lymphedema. Besides preventive approaches of treatment related complications and lymphedema, various therapeutic interventions have been proposed to treat this disabling condition. In the absence of well-designed randomized studies, consensus has not been attained concerning the appropriate treatment of lymphedema. Complex decongestive therapy, manual lymphatic drainage, self-adminitered lymphatic drainage, pneumatic pumps, laser therapy, oral pharmaceuticals, compression bandaging and garments, limb exercises and elevation are among the common conservative therapies used for managing lymphedema. This review overviews the risk factors, assessment methods, preventive approaches and treatment regimens that have been used for the management of lymphedema. Turk J Phys Med Rehab 2009;55:30-35

Low Back Pain in Athletes, Prevention and Rehabilitation Strategies

WOS: 000266016400026Although the prevalence of low back pain in the general population is 80-90%, it is reported as 1-30% among athletes. General risk factors of low back pain are occupational activities such as repeated heavy lifting, pulling or rotational movements, as well as smoking, alterations in spinal biomechanics and geometry, obesity, physical inactivity. Potential risk factors in sports are also reported as abnormal lumbar curvature, bone deformities, hypermobility, muscular strength imbalance, excessive fat weight, advanced training years, poor conditioning, improper equipment, poor technique, repetitive activities and training errors. Baseball, golf, gymnastics, football, swimming, weight lifting, ballet, throwing sports and bicycling are most the common sports with a high risk of low back pain. The lifetime prevalence of low back pain in some sports were 54% in wrestlers, 32% in tennis players, 37% in football players, 79% in gymnasts, 33% in golfers, 65% in skiers, and 63% in rowers. Management of low back pain is planned according to acute or chronic phases. Treatment of acute phase includes short term rest, ice, medications, and gradual muscle stretching and strengthening exercises. Chronic phase treatment modalities include high intensity exercise program to restore lumbar and lower extremity range of motion and muscle strength. Prevention strategies include correcting posture, lifting techniques, effective warm-up period and training methods as well as the elimination of negative environmental conditions

Intraligamentous Calcification of the Medial Collateral Ligament Mimicking Pellegrini-Stieda Syndrome in a Lower-Extremity Amputee

WOS: 000353480500013Soft-tissue calcification is characterized by the accumulation of calcium in damaged collagen fibrils. The pathogenesis of calcium deposition is not fully understood. Inflammatory changes, trauma, and rheumatological diseases have been reported as possible risk factors. Pellegrini-Stieda syndrome (PSS) is post-traumatic calcification or ossification of the medial collateral ligament with a nonspecific etiology. It may occur after trauma or inflammation or it could be idiopathic. Here we present a case of posttraumatic intraligamentous calcification of the medial collateral ligament (MCL) mimicking Pellegrini-Stieda syndrome (PSS) and review the current related literature

Kinesio taping application in a pediatric patient with spinal muscular atrophy

Kinesio taping is one of the elastic bandage methods which has been quite popular in the last 20 years and has been applied in various musculoskeletal conditions. Although the mechanism of action is not clear, many theories have been suggested so far. In this case report, we aimed to present the results of kinesiotape application for back pain of the patient with spinal muscular atrophy which is one of the progressive muscular disorders. It was performed for three times with four days interval. Fascial technique B (Space technique) was applied. Reduce of pain was also observed during the subsequent applications. The application of kinesio taping could be beneficial on reducing the pain in patients with progressive muscle diseases. [Cukurova Med J 2016; 41(2.000): 386-389

Proliferation and differentiation effect on human mesenchymal stem cells by using prolactin hormone

European Biotechnology Conference -- MAY 05-07, 2016 -- LATVIAWOS: 000380240300195

Association of Radiological Grading with Clinical Variables and Functional Status in Patients with Hip and Knee Osteoarthritis

WOS: 000264851900017Objective: The general opinion is that there is a disparity between symptoms and radiological abnormalities in osteoarthritis (OA), but some recent studies emphasize the potential contribution of underlying joint disease to the degree of pain and disability. Our aim was to assess the relationship between radiographic grading and demographic features, clinical variables and functional status in patients with hip and knee OA. Material and Methods: 128 patients (61.8 +/- 9.5 years, 84 knee and 44 hip OA) were included in the study. Demographic features, duration of disease and stiffness, and severity of pain were assessed using visual analog scale (VAS). Range of motion (ROM) measurements and radiological grading were performed. Western Ontario and McMaster Universities OA Index (WOMAC) was used for evaluating pain, stiffness and physical functions, and Short Form-36 (SF-36) was used for evaluating general health status. These variables were compared between three groups based on Kellgren-Lawrence radiological grades (grade 2, 3, 4). Results: Age, body mass index, ROM values, VAS (p = 0.0001), WOMAC pain, function and total score (p = 0.007, p = 0.03 and p = 0.03 respectively), physical functioning, bodily pain, social functioning and emotional role of SF-36 (p = 0.007, p = 0.008, p = 0.02 and p = 0.009 respectively) were worsened according to radiological grade in knee OA. Duration of disease, ROM values, VAS (p = 0.006) and bodily pain subscale of SF-36 (p = 0.03) were worsened in hip OA; no significant difference was detected in WOMAC subscales and total score. Conclusion: Clinical variables, functional status and quality of life deteriorated with radiological grade in knee OA patients and this deterioration was significant in grade 4. However, this association, especially of functional status, could not be confirmed in hip OA patients

Charcot's neuroarthropathy of the hand in a patient with diabetes mellitus

WOS: 000384674200014PubMed ID: 27075802Charcot's neuroarthropathy (CNA) is a destructive disease associated with a reduced proprioceptive sensation. Diabetes mellitus (DM) is one of the most common etiological factor for CNA which typically affects ankles and small joints of feet. Neuroarthropathy seen in upper extremity in patients with DM is a rare clinical condition.In this report, we presented a case of CNA with hand involvement who had type-II DM. Neuroarthropathy was rapidly progressed and destructive changes were observed in right hand joints after a minor trauma in current case.Charcot's neuroarthropathy may rarely occur in the joints of hand in patients with DM. Early diagnosis of CNA is important in order to protect joints and avoid further disability

Biological behaviors of muscarinic receptors in mesenchymal stem cells derived from human placenta and bone marrow

WOS: 000498871600017Objective(s): Cells perform their functional activities by communicating with each other through endogenous substances and receptors. Post-translation, stem cells function properly in new host tissue by carrying specific cell surface receptors. We aimed to characterize muscarinic receptor subtypes in mesenchymal stem cells (MSCs) together with osteogenic and adipogenic differentiation markers. Materials and Methods: mRNA levels of 5 muscarinic receptor subtypes (CHRM1 to 5), BMP-6, and PPAR gamma during osteogenic and adipogenic differentiation, under the effect of atropine blockade, were measured in MSCs obtained from human fetal membrane (FM) and bone marrow (BM). Additionally, the effect of atropine on differentiation in the 1st, 2nd, and 3rd passages of MSCs, obtained from human FM and BM, were analyzed by RT-qPCR. Results: CHRM1 mRNA levels increased in the FM group, while decreasing in the BM group. We found significant decreases in CHRM3 and CHRM5 mRNA levels in FM and BM groups, respectively. Atropine had variable effects based on cell source and receptor type. BMP-6 mRNA levels in differentiated osteogenic cells increased significantly compared to undifferentiated cells in both FM and BM groups. In MSCs derived from both sources, PPAR gamma mRNA levels in differentiated adipogenic cells increased significantly. Atropine showed no effect on MSCs differentiation. Conclusion: These results indicate that expressions of muscarinic receptors in MSCs derived from BM and FM can vary and these cells keep the potential of osteogenic and adipogenic differentiation in vitro. Besides, atropine had no effect on adipogenic and osteogenic differentiation of MSCs.Cukurova University, Scientific Research Projects Fund, Adana, Turkey [TF2014D2]The results presented in this paper were part of a student thesis. The authors express their great gratitude to Canan Cansun and Nilay Oktar for their invaluable help in the RT-qPCR technique. This study was supported by Cukurova University, Scientific Research Projects Fund, Adana, Turkey (project no: TF2014D2)