STUDY ON ANTI-MICROBIAL PROPERTIES OF Enicosanthum membranifolium SINCLAIR AND Enicosanthum cupulare (KING) AIRY-SHAW

 ABSTRACT n-Hexane and ethyl acetate fractions of methanol extracts of two species of Annonaceae, Enicosanthum membranifolium Sinclair and Enicosanthum cupulare (King) Airy-Shaw, were screened for antimicrobial activity against eighteen bacterial strains using agar dilution method. The ethyl acetate fraction of the two Annonaceae plants showed higher antimicrobial activities than the n-hexane fraction. The extracts of the plants tested were significantly more active against gram-positive with minimum inhibitory concentration (MICs) ranging from 0.0625 to 4 mg/mL than against gram negative bacteria (MICs >4 mg/mL). Keywords: Antibacterial activity; Enicosanthum membranifolium Sinclair; Enicosanthum cupulare (King) Airy-Sha

Interaction study of binary solvent systems ionic liquid and deep eutectic solvent with rotenone

[BMIM]OTf and alcohol-based DES combination with a selected organic solvent (acetone and acetonitrile) have been proven to efficiently extracting rotenone (isoflavonoid biopesticide) compound compared to individual organic solvents. Their efficiency builds up interest to study the solvent-solute interaction that occurs between both selected solvent systems with rotenone. The interaction study was analyzed using FTIR, 1D-NMR and 2D- NMR (NOESY, HMBC). Correlation portrayed by NOESY and HMBC of [BMIM]OTf - standard rotenone mixture predicted probable hydrogen bonding between the oxygen of rotenone with acidic proton C2-H of [BMIM]OTf. While for the alcohol-based DES-rotenone mixture, the correlation shows probable interaction to occur between methyl and methoxy group rotenone with the hydroxyl group of 1,4-butanediol. In conclusion, potential hydrogen bonding that occurs between solvent and solute aid towards the solvent efficiency in extracting rotenone compound while emphasizing on the low cost and green mediated solvent systems

6-Benzyloxycoumarin

In the title compound, 6-benzyloxy-2H-1-benzopyran-2-one, C16H12O3, the coumarin unit and benzyl plane in the molecule are perpendicular to each other [86.92 (7)°]. The crystal packing is stabilized by π–π stacking interactions, with an interplanar separation between inversion-related coumarin units of 3.618 (3) Å. The crystal structure shows intermolecular C—H...O hydrogen bonding between neighboring molecules

Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives via a Sequential Knoevenagel Condensation and Hetero-Diels–Alder Reaction in an Aqueous Medium

Utilizing aldehyde-substituted vinylogous carbonates and 1,3-diketones, a simple protocol is presented for the synthesis of 2,8-dioxabicyclo[3.3.1]­nonane derivatives via Knoevenagel condensation followed by a hetero-Diels–Alder reaction under green reaction conditions. The structure of a key product is unequivocally confirmed by X-ray crystallography