2,480 research outputs found
Bi-algebras, generalised geometry and T-duality
A study of sigma models whose target space is a group G that admits a
compatible Poisson structure is presented. The natural action of O(D,D;Z) on
the generalised tangent bundle TG+T*G and a generalisation of the Courant
bracket that appears are reviewed. This background provides a concrete example
where the generalised geometry and doubled geometry descriptions are both well
understood. Connections between the two formalisms are discussed and the
world-sheet theory from Hamiltonian and Lagrangian perspectives is
investigated. The comparisons between the approaches given by generalised
geometry and doubled geometry suggest possible ways of generalising the
analysis beyond the known examples.Comment: 43 page
Lecture capture: Is more always better?
The impact of providing back-up recorded lectures on student wellbeing and achievement
The Accelerations of Stars Orbiting the Milky Way's Central Black Hole
Recent measurements, of the velocities of stars near the center of the Milky
Way have provided the strongest evidence for the presence of a supermassive
black hole in a galaxy, but the observational uncertainties poorly constrain
many of the properties of the black hole. Determining the accelerations of
stars in their orbits around the center provides much more precise information
about the position and mass of the black hole. Here we report measurements of
the accelerations for three stars located ~0.005 pc from the central radio
source Sgr A*; these accelerations are comparable to those experienced by the
Earth as it orbits the Sun. These data increase the inferred minimum mass
density in the central region of the Galaxy by an order of magnitude relative
to previous results and localized the dark mass to within 0.05 +- 0.04 arcsec
of the nominal position of Sgr A*. In addition, the orbital period of one of
the observed stars could be as short as 15 years, allowing us the opportunity
in the near future to observe an entire period.Comment: To appear in September 21 2000 issue of Natur
MicroRNAs regulate Ca2+ homeostasis in murine embryonic stem cells
MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways differently expressed in the absence of miRNAs due to the deletion of Dicer, which encodes an RNase that is essential for the synthesis of miRNAs. One pathway that stood out was Ca2+ signaling. Interestingly, we found that Dicer-/- ESCs had no difference in basal cytoplasmic Ca2+ levels but were hyperresponsive when Ca2+ import into the endoplasmic reticulum (ER) was blocked by thapsigargin. Remarkably, the increased Ca2+ response to thapsigargin in ESCs resulted in almost no increase in apoptosis and no differences in stress response pathways, despite the importance of miRNAs in the stress response of other cell types. The increased Ca2+ response in Dicer-/- ESCs was also observed during purinergic receptor activation, demonstrating a physiological role for the miRNA regulation of Ca2+ signaling pathways. In examining the mechanism of increased Ca2+ responsiveness to thapsigargin, neither store-operated Ca2+ entry nor Ca2+ clearance mechanisms from the cytoplasm appeared to be involved. Rather, it appeared to involve an increase in the expression of one isoform of the IP3 receptors (Itpr2). miRNA regulation of Itpr2 expression primarily appeared to be indirect, with transcriptional regulation playing a major role. Therefore, the miRNA regulation of Itpr2 expression offers a unique mechanism to regulate Ca2+ signaling pathways in the physiology of pluripotent stem cells
The Mass Function of Newly Formed Stars (Review)
The topic of the stellar "original mass function" has a nearly 50 year
history,dating to the publication in 1955 of Salpeter's seminal paper. In this
review I discuss the many more recent results that have emerged on the initial
mass function (IMF), as it is now called, from studies over the last decade of
resolved populations in star forming regions and young open clusters.Comment: 9 pages, 1 figure; to appear in "The Dense Instellar Medium in
Galaxies -- 4'th Cologne-Bonn-Zermatt-Symposium" editted by S. Pfalzner, C.
Kramer, C. Straubmeier and A. Heithausen, Springer-Verlag (2004
Globular Cluster Distance Determinations
The present status of the distance scale to Galactic globular clusters is
reviewed. Six distance determination techniques which are deemed to be most
reliable are discussed in depth. These different techniques are used to
calibrate the absolute magnitude of the RR Lyrae stars. The various
calibrations fall into three groups. Main sequence fitting using Hipparcos
parallaxes, theoretical HB models and the RR Lyrae in the LMC all favor a
bright calibration, implying a `long' globular cluster distance scale. White
dwarf fitting and the astrometric distances yield a somewhat fainter RR Lyrae
calibration, while the statistical parallax solution yields faint RR Lyrae
stars implying a `short' distance scale to globular clusters. Various secondary
distance indicators discussed all favor the long distance scale. The `long' and
`short' distance scales differ by (0.31+/-0.16) mag. Averaging together all of
the different distance determinations yields Mv(RR) = (0.23+/-0.04)([Fe/H] +
1.6) + (0.56+/-0.12) mag.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in pres
Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
BACKGROUND: Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to develop more effective anti-cancer drugs in dogs. SG2000 (SJG-136) is a sequence selective DNA minor groove cross-linking agent. Based on its in vitro potency, the spectrum of in vivo and clinical activity against human tumours, and its tolerability in human patients, SG2000 has potential as a novel therapeutic against spontaneously occurring canine malignancies. RESULTS: In vitro cytotoxicity was assessed using SRB and MTT assays, and in vivo activity was assessed using canine tumour xenografts. DNA interstrand cross-linking (ICL) was determined using a modification of the single cell gel electrophoresis (comet) assay. Effects on cell cycle distribution were assessed by flow cytometry and measurement of Îł-H2AX by immunofluorescence and immunohistochemistry. SG2000 had a multi-log differential cytotoxic profile against a panel of 12 canine tumour cell lines representing a range of common tumour types in dogs. In the CMeC-1 melanoma cell line, DNA ICLs increased linearly with dose following a 1Â h treatment. Peak ICL was achieved within 1Â h and no removal was observed over 48Â h. A relationship between DNA ICL formation and cytotoxicity was observed across cell lines. The formation of Îł-H2AX foci was slow, becoming evident after 4Â h and reaching a peak at 24Â h. SG2000 exhibited significant anti-tumour activity against two canine melanoma tumour models in vivo. Anti-tumour activity was observed at 0.15 and 0.3Â mg/kg given i.v. either once, or weekly x 3. Dose-dependent DNA ICL was observed in tumours (and to a lower level in peripheral blood mononuclear cells) at 2Â h and persisted at 24Â h. ICL increased following the second and third doses in a repeated dose schedule. At 24Â h, dose dependent Îł-H2AX foci were more numerous than at 2Â h, and greater in tumours than in peripheral blood mononuclear cells. SG2000-induced H2AX phosphorylation measured by immunohistochemistry showed good correspondence, but less sensitivity, than measurement of foci. CONCLUSIONS: SG2000 displayed potent activity in vitro against canine cancer cell lines as a result of the formation and persistence of DNA ICLs. SG2000 also had significant in vivo antitumour activity against canine melanoma xenografts, and the comet and Îł-H2AX foci methods were relevant pharmacodynamic assays. The clinical testing of SG2000 against spontaneous canine cancer is warranted. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-015-0534-2) contains supplementary material, which is available to authorized users
The RR Lyrae Distance Scale
We review seven methods of measuring the absolute magnitude M_V of RR Lyrae
stars in light of the Hipparcos mission and other recent developments. We focus
on identifying possible systematic errors and rank the methods by relative
immunity to such errors. For the three most robust methods, statistical
parallax, trigonometric parallax, and cluster kinematics, we find M_V (at
[Fe/H] = -1.6) of 0.77 +/- 0.13, 0.71 +/- 0.15, 0.67 +/- 0.10. These methods
cluster consistently around 0.71 +/- 0.07. We find that Baade-Wesselink and
theoretical models both yield a broad range of possible values (0.45-0.70 and
0.45-0.65) due to systematic uncertainties in the temperature scale and input
physics. Main-sequence fitting gives a much brighter M_V = 0.45 +/- 0.04 but
this may be due to a difference in the metallicity scales of the cluster giants
and the calibrating subdwarfs. White-dwarf cooling-sequence fitting gives 0.67
+/- 0.13 and is potentially very robust, but at present is too new to be fully
tested for systematics. If the three most robust methods are combined with
Walker's mean measurement for 6 LMC clusters, V_{0,LMC} = 18.98 +/- 0.03 at
[Fe/H] = -1.9, then mu_{LMC} = 18.33 +/- 0.08.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in press. 21
pages including 1 table; uses Kluwer's crckapb.sty LaTeX style file, enclose
The CP walker for strength training in children with spastic cerebral palsy:A training program proposal
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