21 research outputs found
Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila
No full textThe five faces of notch signalling during Drosophila melanogaster embryonic CNS development
No full textDuring central nervous system (CNS) development, a complex series of events play out, starting with the establishment of neural progenitor cells, followed by their asymmetric division and formation of lineages and the differentiation of neurons and glia. Studies in the Drosophila melanogaster embryonic CNS have revealed that the Notch signal transduction pathway plays at least five different and distinct roles during these events. Herein, we review these many faces of Notch signalling and discuss the mechanisms that ensure context-dependent and compartment-dependent signalling. We conclude by discussing some outstanding issues regarding Notch signalling in this system, which likely have bearing on Notch signalling in many species
Drosophila S6 Kinase Like Inhibits Neuromuscular Junction Growth by Downregulating the BMP Receptor Thickveins
No full textDisruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders
No full textBMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
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Landscape and well-being: a scoping study on the health-promoting impact of outdoor environments
No full textThe calcium channel subunit α2δ-3 organizes synapses via an activity-dependent and autocrine BMP signaling pathway
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