Screening of catharanthus roseus stem extract for anti-ulcer potential in wistar rat

This study aims to evaluate the anti-ulcer effect of Catharanthus roseus Stem extract on gastric ulcers caused by forced swimming. It was investigated that Catharanthus roseus having many kinds of phytochemical constituents so it is responsible for different pharmacological actions. The ethanolic extract of Catharanthus roseus stem at 250 and 500 mg/kg orally (PO) significantly reduces the incidence of ulcers. In this investigation albino wistar rats induced by forced swimming, an increase in the rate of ulcers was observed compared to the control group. The ethanol extract of Catharanthus roseus stem showed a significant decrease in the previous index at a dose of 500 mg/kg; it was comparable to the standard preparation ranitidine (5 mg/kg). The protection index of Catharanthus roseus stem extract was 65.4%, while the protection index of the standard preparation ranitidine was 76.8%