Two-phase velocity measurement in a particle-laden jet

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E-cadherin and gastric cancer: Cause, consequence and applications

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Vortex formation processes from an oscillating circular cylinder at high Keulegan-Carpenter numbers

Development of vortex patterns around a circular cylinder oscillating in quiescent water is investigated using time-resolved particle image velocimetry. Experiments are performed at Keulegan–Carpenter (KC) numbers between 8 and 36 with Reynolds number kept constant at 2400. Similar to previous studies, three modes of vortex patterns are identified and denoted as modes I, II, and III. The development of vortices in each mode at successive phases of cylinder oscillation is studied in details. The classification of modes is based on the development mechanism of shear layers around the cylinder, the number of vortices shed in each half cycle, and the characteristics of the vortex street. Modes I, II, and III are characterized by one, two, and three (or more) vortices generated, respectively, in each half cycle. The appropriate vortex formation length is applied to explain the dependence of number of vortices formed in each cylinder cycle on KC. Vortex shedding in mode I occurs only on one side of the line of cylinder motion. This mode, which occurs at KC between 8 and 16, is observed to have two submodes with different orientations of the vortex street to the line of cylinder motion. Mode II occurs at KC between 16 and 24. The vortex street extends to both sides of the line of cylinder motion and lies at about 45° to it. At KC>24, vortices are shed behind the moving cylinder similar to the case of a towed cylinder. The limited-length vortex street in this mode III pattern lies along the line of cylinder motion. Each vortex pattern is associated with a typical secondary flow stream, which affects distinct evolution stages of vortices around the cylinder and hence the unique vortex pattern. The development of vortices is found to involve complex vortex interaction involving migration, stretching, and splitting.published_or_final_versio

Conditional bounds for small prime solutions of linear equations

Let a 1, a 2, a 3 be non-zero integers with gcd(a 1 a 2, a 3)=1 and let b be an arbitrary integer satisfying gcd (b, a i, a j) =1 for i≠j and b≡a 1+a 2+a 3 (mod 2). In a previous paper [3] which completely settled a problem of A. Baker, the 2nd and 3rd authors proved that if a 1, a 2, a 3 are not all of the same sign, then the equation a 1 p 1+a 2 p 2+a 3 p 3=b has a solution in primes p j satisfying {Mathematical expression} where A>0 is an absolute constant. In this paper, under the Generalized Riemann Hypothesis, the authors obtain a more precise bound for the solutions p j . In particular they obtain A0. An immediate consquence of the main result is that the Linnik's courtant is less than or equal to 2. © 1992 Springer-Verlag.postprin

Potential core lengths of round jets in stagnant and moving environments

This paper investigates the change of velocity and concentration fields in the initial region of a round jet in stagnant fluid and in a moving environment of the co-flow, counter-flow or cross-flow situation. The aim was to discuss issues of flow establishment and in the initial region, to determine the potential core length, and to observe the effect of a moving ambient. Turbulent jet velocities and concentration were measured with the planar imaging techniques of particle-image velocimetry (PIV) and laser-induced fluorescence (LIF). The mean flow fields were obtained and analyzed to investigate the validity of 1/. x decay relationship for jet centerline velocity and concentration. Values for the decay constant and jet virtual origin were obtained from the data. While the results show that the decay constant is increased by a co-flow but reduced by a counter-flow or a cross-flow, the virtual origin was found to be affected as well. The overall effect is that any situation of the moving environment leads to a slight reduction of the physical length of the potential core. The paper also suggests an intermittency function for the analysis of fluctuating jet concentration field in the potential core. The mean intermittency function provides a direct and reliable estimate of the potential core length of a jet in a moving environment. © 2011 International Association of Hydro-environment Engineering and Research, Asia Pacific Division.postprin

A Serratia marcescens PigP Homolog Controls Prodigiosin Biosynthesis, Swarming Motility and Hemolysis and Is Regulated by cAMP-CRP and HexS

Swarming motility and hemolysis are virulence-associated determinants for a wide array of pathogenic bacteria. The broad host-range opportunistic pathogen Serratia marcescens produces serratamolide, a small cyclic amino-lipid, that promotes swarming motility and hemolysis. Serratamolide is negatively regulated by the transcription factors HexS and CRP. Positive regulators of serratamolide production are unknown. Similar to serratamolide, the antibiotic pigment, prodigiosin, is regulated by temperature, growth phase, HexS, and CRP. Because of this co-regulation, we tested the hypothesis that a homolog of the PigP transcription factor of the atypical Serratia species ATCC 39006, which positively regulates prodigiosin biosynthesis, is also a positive regulator of serratamolide production in S. marcescens. Mutation of pigP in clinical, environmental, and laboratory strains of S. marcescens conferred pleiotropic phenotypes including the loss of swarming motility, hemolysis, and severely reduced prodigiosin and serratamolide synthesis. Transcriptional analysis and electrophoretic mobility shift assays place PigP in a regulatory pathway with upstream regulators CRP and HexS. The data from this study identifies a positive regulator of serratamolide production, describes novel roles for the PigP transcription factor, shows for the first time that PigP directly regulates the pigment biosynthetic operon, and identifies upstream regulators of pigP. This study suggests that PigP is important for the ability of S. marcescens to compete in the environment. © 2013 Shanks et al

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade

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Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy

A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical castration, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of castration resistance. Here, we showed that in LNCaP and 22Rv1 prostate cancer cells transiently overexpressing androgen receptor splice variant-7 (AR-V7), nuclear factor-kappa B (NF-κB) was activated and could result in up-regulated interleukin (IL)-6 gene expression, indicating a positive interaction between AR-V7 expression and activated NF-κB/IL-6 signaling in castration-resistant prostate cancer (CRPC) pathogenesis. Importantly, both AR-V7-induced NF-κB activation and IL-6 gene transcription in LNCaP and 22Rv1 cells could be inhibited by melatonin. Furthermore, stimulation of AR-V7 mRNA expression in LNCaP cells by betulinic acid, a pharmacological NF-κB activator, was reduced by melatonin treatment. Our data support the presence of bi-directional positive interactions between AR-V7 expression and NF-κB activation in CRPC pathogenesis. Of note, melatonin, by inhibiting NF-κB activation via the previously-reported MT₁ receptor-mediated antiproliferative pathway, can disrupt these bi-directional positive interactions between AR-V7 and NF-κB and thereby delay the development of castration resistance in advanced prostate cancer. Apparently, this therapeutic potential of melatonin in advanced prostate cancer/CRPC management is worth translation in the clinic via combined androgen depletion and melatonin repletion.published_or_final_versio

Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma

Background. Resection of hepatocellular carcinoma is associated with high rates of morbidity and mortality. Since intensive nutritional support can reduce the catabolic response and improve protein synthesis and liver regeneration, we performed a prospective study to investigate whether perioperative nutritional support could improve outcome in patients undergoing hepatectomy for hepatocellular carcinoma. Methods. We studied 124 patients undergoing resection of hepatocellular carcinoma. Sixty-four patients (39 with cirrhosis, 18 with chronic active hepatitis, and 7 with no associated liver disease) were randomly assigned to receive perioperative intravenous nutritional support in addition to their oral diet, and 60 patients (33 with cirrhosis, 12 with chronic active hepatitis, and 15 with no associated liver disease) were randomly assigned to a control group. The perioperative nutritional therapy consisted of a solution enriched with 35 percent branched-chain amino acids, dextrose, and lipid emulsion (50 percent medium-chain triglycerides) given intravenously for 14 days perioperatively. Results. There was a reduction in the overall postoperative morbidity rate in the perioperative-nutrition group as compared with the control group (34 percent vs. 55 percent; relative risk, 0.66; 95 percent confidence interval, 0.45 to 0.96), predominantly because of fewer septic complications (17 percent vs. 37 percent; relative risk, 0.57; 95 percent confidence interval, 0.34 to 0.96). There were also a reduction in the requirement for diuretic agents to control ascites (25 percent vs. 50 percent; relative risk, 0.57; 95 percent confidence interval, 0.37 to 0.87), less weight loss after hepatectomy (median loss, 0 kg vs. 1.4 kg; P = 0.01), and less deterioration of liver function as measured by the change in the rate of clearance of indocyanine green (-2.8 percent vs. -4.8 percent at 20 minutes, P = 0.05). These benefits were seen predominantly in the patients with underlying cirrhosis who underwent major hepatectomy. There were five deaths during hospitalization in the perioperative-nutrition group, and nine in the control group (P not significant). Conclusions. Perioperative nutritional support can reduce complications after major hepatectomy for hepatocellular carcinoma associated with cirrhosis.published_or_final_versio