Severe bronchopulmonary dysplasia improved by noninvasive positive pressure ventilation: a case report

<p>Abstract</p> <p>Introduction</p> <p>This is the first report to describe the feasibility and effectiveness of noninvasive positive pressure ventilation in the secondary treatment of bronchopulmonary dysplasia.</p> <p>Case presentation</p> <p>A former male preterm of Caucasian ethnicity delivered at 29 weeks gestation developed severe bronchopulmonary dysplasia. At the age of six months he was in permanent tachypnea and dyspnea and in need of 100% oxygen with a flow of 2.0 L/minute via a nasal cannula. Intermittent nocturnal noninvasive positive pressure ventilation was then administered for seven hours daily. The ventilator was set at a positive end-expiratory pressure of 6 cmH₂O, with pressure support of 4 cmH₂O, trigger at 1.4 mL/second, and a maximum inspiratory time of 0.7 seconds. Over the course of seven weeks, the patient's maximum daytime fraction of inspired oxygen via nasal cannula decreased from 1.0 to 0.75, his respiratory rate from 64 breaths/minute to 50 breaths/minute and carbon dioxide from 58 mmHg to 44 mmHg.</p> <p>Conclusion</p> <p>Noninvasive positive pressure ventilation may be a novel therapeutic option for established severe bronchopulmonary dysplasia. In the case presented, noninvasive positive pressure ventilation achieved sustained improvement in ventilation and thus prepared our patient for safe home oxygen therapy.</p

Effect of induced hypothermia on lipopolysaccharide-induced lung injury in neonatal rats

Objectives: Recent data suggest that induced hypothermia has some protective effects on experimental lung injury. We aimed to evaluate the protective effect of mild hypothermia in a rat model of lipopolysaccharide (LPS) induced neonatal lung injury

Ethnic ties, motivations, and home country entry strategy of transnational entrepreneurs

Based on 30 in-depth interviews with Indian transnational entrepreneurs (TEs) in the USA and their corresponding India heads of operations, we explore the influence of TEs’ ethnic ties on their motivations and entry strategy in the formation of transnational ventures in their home country. Our findings show the heterogeneity of TEs’ motivations (economic and emotional) and home country entry strategy (proactive and reactive). Further, we find that TEs’ entry strategy is contingent on their (a) use of professional and personal ethnic ties and (b) prior experience of doing business with the home country. These findings contribute to the transnational and immigrant entrepreneurship literatures

Exploring board formation and evolution of board composition in academic spin-offs

Boards of directors, Academic spin-offs, Stages, Resources, Social networks, M13, M10,