Extended x-ray absorption fine structure study of porous GaSb formed by ion implantation

Porous GaSb has been formed by Ga ion implantation into crystalline GaSb substrates at either room temperature or −180 °C. The morphology has been characterized using scanning electron microscopy and the atomic structure was determined using extended x-ray absorption fine structure spectroscopy. Room-temperature implantation at low fluences leads to the formation of ∼20-nm voids though the material remains crystalline. Higher fluences cause the microstructure to evolve into a network of amorphous GaSb rods ∼15 nm in diameter. In contrast, implantation at −180 °C generates large, elongated voids but no rods. Upon exposure to air, the surface of the porous material is readily oxidized yielding Ga₂O₃ and metallic Sb precipitates, the latter resulting from the reduction of unstable Sb₂O₃. We consider and discuss the atomic-scale mechanisms potentially operative during the concurrent crystalline-to-amorphous and continuous-to-porous transformations

The in silico macrophage: toward a better understanding of inflammatory disease

Macrophages function as sentinel, cell-regulatory hubs capable of initiating, perpetuating and contributing to the resolution of an inflammatory response, following their activation from a resting state. Highly complex and varied gene expression programs within the macrophage enable such functional diversity. To investigate how programs of gene expression relate to the phenotypic attributes of the macrophage, the development of in silico modeling methods is needed. Such models need to cover multiple scales, from molecular pathways in cell-autonomous immunity and intercellular communication pathways in tissue inflammation to whole organism response pathways in systemic disease. Here, we highlight the potential of in silico macrophage modeling as an amenable and important yet under-exploited tool in aiding in our understanding of the immune inflammatory response. We also discuss how in silico macrophage modeling can help in future therapeutic strategies for modulating both the acute protective effects of inflammation (such as host defense and tissue repair) and the harmful chronic effects (such as autoimmune diseases).Comment: 7 pages plus 1 figur

TWEAK: a novel biomarker for lupus nephritis?

Renal involvement is common in systemic lupus erythematosus. Early diagnosis of lupus nephritis (LN), allowing the instigation of appropriate therapy, remains an important clinical challenge. Current biomarkers in clinical practice are less than ideal, lacking both sensitivity and specificity. In the previous issue of Arthritis Research & Therapy, Schwartz and colleagues demonstrated the potential value of urinary TNF-like weak inducer of apoptosis (uTWEAK) as a biomarker for LN. They showed that uTWEAK is elevated in subjects with LN at diagnosis compared with those with systemic lupus erythematosus but no renal disease, and correlates with the degree of clinical disease activity. These data are thought-provoking and provide the platform for future longer-term studies

Study of moments of event shapes in e+e- annihilation using JADE data

Data from e+e- annihilation into hadrons collected by the JADE experiment at centre-of-mass energies between 14 GeV and 44 GeV were used to study moments of event shape distributions. The data were compared with Monte Carlo models and with predictions from QCD NLO order calculations. The strong coupling constant measured from the moments is alpha_S(M_Z) = 0.1286 +/- 0.0007 (stat) +/- 0.0011 (expt) +/- 0.0022 (had) +/- 0.0068 (theo), alpha_S(M_Z) = 0.1286 +/- 0.0072 (total error), consistent with the world average. However, systematic deficiencies in the QCD NLO order predictions are visible for some of the higher moments.Comment: JADE note 147 submitted as contributed paper to ICHEP 2004, corrected statistical error of 6 observable average and several typo

Untersuchungen zum Gehalt an ME und praecaecal verdaulichen Aminosäuren aus einem Gemisch thermisch behandelter Körnerleguminosen (LEGUMI-therm®) beim Broiler

The objective of this study was to assess the effect of heating a mixture of grain legumes based on sweet lupins, faba beans, and peas (1:1:1, toasted “LEGUMItherm ®”; untreated: “LEGUMI-mix”) on the content of metabolisable energy (ME) and precaecal digestible (pc) amino acids for broilers. The mean of amino acid digestibility of LEGUMI-mix and LEGUMI-therm was 88 and 87 %. The ME content of the mixture ranged between 11.9 (LEGUMI-therm) and 12.1 MJ/kg DM (LEGUMI-mix). Both parameters were unaffected by heating

Measurement of the Strong Coupling Constant alpha_S from the Four-Jet Rate in e+e- Annihilation using JADE data

Data from e+e- annihilation into hadrons collected by the JADE experiment at centre-of-mass energies between 14 GeV and 44 GeV were used to study the four-jet rate as a function of the Durham algorithm's resolution parameter y_cut. The four-jet rate was compared to a QCD NLO order calculations including NLLA resummation of large logarithms. The strong coupling constant measured from the four-jet rate is alpha_S(M_Z) = 0.1169 +/- 0.0004 (stat) +/- 0.0012 (expt) +/- 0.0021 (had) +/- 0.0007 (theo), alpha_S(M_Z) = 0.1169 +/- 0.0026 (total error) in agreement with the world average.Comment: JADE note 146 submitted as contributed paper to ICHEP 200

Nanoscale density fluctuations in swift heavy ion irradiated amorphous SiO2

We report on the observation of nanoscale density fluctuations in 2 μm thick amorphous SiO₂ layers irradiated with 185 MeV Au ions. At high fluences, in excess of approximately 5 × 10¹² ions/cm², where the surface is completely covered by ion tracks, synchrotron small angle x-ray scattering measurements reveal the existence of a steady state of density fluctuations. In agreement with molecular dynamics simulations, this steady state is consistent with an ion track “annihilation” process, where high-density regions generated in the periphery of new tracks fill in low-density regions located at the center of existing tracks.The authors acknowledge the Australian Research Council and the Australian Synchrotron Research Program for financial support and thank the staff at the ANU Heavy Ion facility for their continued technical assistance. O.P., F.D., and K.N. acknowledge financial support from the Academy of Finland under its Centre of Excellence program as well as the OPNA project, and grants of computer capacity from CSC

Formation and structural characterization of Ni nanoparticles embedded in SiO₂

Face-centered cubic Ni nanoparticles were formed in SiO₂ by ion implantation and thermal annealing. Small-angle x-ray scattering in conjunction with transmission electron microscopy was used to determine the nanoparticle size as a function of annealing temperature, whereas the local atomic structure was measured with x-ray absorption spectroscopy. The influence of finite-size effects on the nanoparticle structural properties was readily apparent and included a decrease in coordination number and bond length and an increase in structural disorder for decreasing nanoparticle size. Such results are consistent with the non-negligible surface-to-volume ratio characteristic of nanoparticles. In addition, temperature-dependent x-ray absorption spectroscopy measurements showed the mean vibrational frequency (as obtained from the Einstein temperature) decreased with decreasing nanoparticle size. This reduction was attributed to the greater influence of the loosely bound, under-coordinated surface atoms prevailing over the effects of capillary pressure, the former enhancing the low frequency modes of the vibrational density of statesThis work was financially supported by the Australian Synchrotron and the Australian Research Council with access to equipment provided by the Australian Nanofabrication Facility