13 research outputs found
Separation of Biological Particles in a Modular Platform of Cascaded Deterministic Lateral Displacement Modules
Whole blood profiling reveals biophysical immune response signatures for clinical triage
Multi-modal analysis of tumor-derived extracellular vesicles immunocaptured from plasma1169-117
Asymmetrical Deterministic Lateral Displacement Gaps for Dual Functions of Enhanced Separation and Throughput of Red Blood Cells
Effect of angle-of-attacks on deterministic lateral displacement (DLD) with symmetric airfoil pillars
Gravity driven deterministic lateral displacement for suspended particles in a 3D obstacle array
Fluorescent label-free quantitative detection of nano-sized bioparticles using a pillar array
Calculating the motion of highly confined, arbitrary-shaped particles in Hele–Shaw channels
We combine theory and numerical calculations to accurately predict the motion of anisotropic particles in shallow microfluidic channels, in which the particles are strongly confined in the vertical direction. We formulate an effective quasi-two-dimensional description of the Stokes flow around the particle via the Brinkman equation, which can be solved in a time that is two orders of magnitude faster than the three-dimensional problem. The computational speedup enables us to calculate the full trajectories of particles in the channel. To validate our scheme, we study the motion of dumbbell-shaped particles that are produced in a microfluidic channel using ‘continuous-flow lithography’. Contrary to what was reported in earlier work (Uspal et al. in Nat Commun 4:2666, 2013), we find that the reorientation time of a dumbbell particle in an external flow exhibits a minimum as a function of its disk size ratio. This finding is in excellent agreement with new experiments, thus confirming the predictive power of our scheme.Intensified Reaction and Separation System