Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines

ArticleJOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 97(1-2): 173-177 (2005)journal articl

IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis

The definitive version is available at www.blackwell-synergy.com.ArticleAMERICAN JOURNAL OF GASTROENTEROLOGY. 102(3): 691-692 (2007)journal articl

Pancreatic exocrine insufficiency: a rare cause of nonalcoholic steatohepatitis

This is an electronic version of an Article published in the American Journal of Gastroenterology 2008; 103(1): 245-246.ArticleAmerican journal of gastroenterology. 103(1): 245-246 (2008)journal articl

Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis

The original publication is available at www.springerlink.com.ArticleJOURNAL OF GASTROENTEROLOGY. 41(12): 1197-1205 (2006)journal articl

Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients

ArticleAMERICAN JOURNAL OF GASTROENTEROLOGY. 103(3):588-594 (2008)journal articl

Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis

ArticleCLINICAL IMMUNOLOGY. 122(3): 338-342 (2007)journal articl

Functional MRI evidence for the decline of word retrieval and generation during normal aging

International audienceThis fMRI study aimed to explore the effect of normal aging on word retrieval and generation. The question addressed is whether lexical production decline is determined by a direct mechanism, which concerns the language operations or is rather indirectly induced by a decline of executive functions. Indeed, the main hypothesis was that normal aging does not induce loss of lexical knowledge, but there is only a general slowdown in retrieval mechanisms involved in lexical processing , due to possible decline of the executive functions. We used three tasks (verbal fluency, object naming , and semantic categorization). Two groups of participants were tested (Young, Y and Aged, A), without cognitive and psychiatric impairment and showing similar levels of vocabulary. Neuropsychological testing revealed that older participants had lower executive function scores, longer processing speeds, and tended to have lower verbal fluency scores. Additionally, older participants showed higher scores for verbal automa-tisms and overlearned information. In terms of behav-ioral data, older participants performed as accurate as younger adults, but they were significantly slower for the semantic categorization and were less fluent for verbal fluency task. Functional MRI analyses suggested that older adults did not simply activate fewer brain regions involved in word production, but they actually showed an atypical pattern of activation. Significant correlations between the BOLD (Blood Oxygen Level Dependent) signal of aging-related (A > Y) regions and cognitive scores suggested that this atypical pattern of the activation may reveal several compensatory mechanisms (a) to overcome the slowdown in retrieval, due to the decline of executive functions and processing speed and (b) to inhibit verbal automatic processes. The BOLD signal measured in some other aging-dependent regions did not correlate with the behavioral and neuro-psychological scores, and the overactivation of these uncorrelated regions would simply reveal dedifferentia-tion that occurs with aging. Altogether, our results suggest that normal aging is associated with a more difficult access to lexico-semantic operations and representations by a slowdown in executive functions, without any conceptual loss

Cerebral Glucose Metabolic Rate in Visual Cortices Associated with Visual Dysfunction in Multi-Infarct Dementia

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