Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo

Broad applications of single-walled carbon nanotubes (SWCNT) dictate the necessity to better understand their health effects. Poor recognition of non-functionalized SWCNT by phagocytes is prohibitive towards controlling their biological action. We report that SWCNT coating with a phospholipid “eat-me” signal, phosphatidylserine (PS), makes them recognizable in vitro by different phagocytic cells - murine RAW264.7 macrophages, primary monocyte-derived human macrophages, dendritic cells, and rat brain microglia. Macrophage uptake of PS-coated nanotubes was suppressed by the PS-binding protein, Annexin V, and endocytosis inhibitors, and changed the pattern of pro- and anti-inflammatory cytokine secretion. Loading of PS-coated SWCNT with pro-apoptotic cargo (cytochrome c) allowed for the targeted killing of RAW264.7 macrophages. In vivo aspiration of PS-coated SWCNT stimulated their uptake by lung alveolar macrophages in mice. Thus, PS-coating can be utilized for targeted delivery of SWCNT with specified cargoes into professional phagocytes, hence for therapeutic regulation of specific populations of immune-competent cells

Preparation, characterization and physical properties of mixed Sb1-xBixTeI

We have synthesized Sb1-xBixTeI (where x = 0.1, 0.4 and 0.9.). The structural variation, electrical resistivity, diffuse reflectance spectroscopy and surface morphology of Sb1-xBixTeI have been studied. The compounds crystallize with the triclinic symmetry. The temperature dependence of electrical resistivity exhibits semiconducting behaviour. The activation energy and band gap of pure SbTeI are found to be 0.37 and 0.73 eV, respectively

Laser irradiation of carbon nanotubes

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Probing giant reduction of T-c in the Li(Ti1-xVx)(2)O-4 spinel system

The doping effect of Vanadium in polycrystalline LiTi2O4 material is carefully analysed. We report on the derailed electrical and magnetic properties of Li(Ti1-xVx)(2)O-4 system for 0 less than or equal to x less than or equal to 0.05 with an emphasis on the low Vanadium concentration. We have an interesting finding to report in that the doping of Vanadium in LiTi2O4, leads to a giant T-c, reduction. The localized magnetic moments induced by the Vanadium doping seem to be responsible for the reduction in T-c. (C) 1998 Published by Elsevier Science Ltd. All rights reserved

Preparation and fundamental physical properties of the quaternary chalcogenides SnBi4-xTe3+ySe4-z and PbBi4-xTe3-ySe4-z

The quaternary chalcogenides SnBi4-xTe3+ySe4-z and PbBi4-xTe3-ySe4-z have been prepared and found to possess orthorhombic structure. The chemical composition of materials is confirmed by EDX. SnBi4-xTe3+ySe4-z and PbBi4-xTe3-ySe4-z exhibit a low resistivity 0.0055 ohm cm and 0.1665 ohm cm at room temperature and carrier concentration 7.15 x 10(18) and 1.97 x 10(16) cm(-3) respectively. The Hall measurements show n-type behaviour with mobility of carrier 87 and 2534 M-2/V, and band gap by diffuse reflectance are found to be 4.37 eV and 3.98 eV for SnBi4-xTe3+ySe4-z and PbBi4-xTe3-ySe4-z respectively