4 research outputs found
TRANSIENT NEW-ONSET ATRIAL FIBRILLATION IS ASSOCIATED WITH POOR CLINICAL OUTCOMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Defining âearlyâ cranioplasty to achieve lower complication rates of bone flap failure: resorption and infection
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation (http://www.immunophenotype.org). Specifically, high-throughput phenotyping of 530 unique mouse gene knockouts identified 140 monogenic âhitsâ, of which most had no previous immunologic association. Furthermore, hits were collectively enriched in genes for which humans show poor tolerance to loss of function. The immunophenotyping platform also exposed dense correlation networks linking immune parameters with each other and with specific physiologic traits. Such linkages limit freedom of movement for individual immune parameters, thereby imposing genetically regulated âimmunologic structuresâ, the integrity of which was associated with immunocompetence. Hence, we provide an expanded genetic resource and structural perspective for understanding and monitoring immune variation in health and disease