Adolescents with Obstructive Sleep Apnea Adhere Poorly to Positive Airway Pressure (PAP), but PAP Users Show Improved Attention and School Performance

Background: Obstructive Sleep Apnea (OSA) is associated with medical and neurobehavioral morbidity across the lifespan. Positive airway pressure (PAP) treatment has demonstrated efficacy in treating OSA and has been shown to improve daytime functioning in adults, but treatment adherence can be problematic. There are nearly no published studies examining functional outcomes such as academic functioning in adolescents treated with PAP. This study was conducted as an initial step towards determining whether PAP treatment improves daytime functioning among adolescents with OSA. Methods: Self-reported academic grades, self- and parent-reported academic quality of life, and objectively-measured attention were assessed before and after PAP was clinically initiated in a sample of 13 obese adolescents with OSA, as well as 15 untreated obese Controls without OSA. Based on adherence data, the treated group was divided into PAP Users (n = 6) and Non-Adherent participants (n = 7). Results: Though demographically similar, the three groups significantly differed in how their academic performance and attention scores changed from baseline to follow-up. Non-Adherent participants showed worsening functioning over time, while PAP Users showed stable or improved functioning, similar to controls. Conclusion: Although many adolescents prescribed PAP for OSA are non-adherent to the treatment, those who adhere t

The consolidation of implicit sequence memory in obstructive sleep apnea

Obstructive Sleep Apnea (OSA) Syndrome is a relatively frequent sleep disorder characterized by disrupted sleep patterns. It is a well-established fact that sleep has beneficial effect on memory consolidation by enhancing neural plasticity. Implicit sequence learning is a prominent component of skill learning. However, the formation and consolidation of this fundamental learning mechanism remains poorly understood in OSA. In the present study we examined the consolidation of different aspects of implicit sequence learning in patients with OSA. We used the Alternating Serial Reaction Time task to measure general skill learning and sequence-specific learning. There were two sessions: a learning phase and a testing phase, separated by a 10-hour offline period with sleep. Our data showed differences in offline changes of general skill learning between the OSA and control group. The control group demonstrated offline improvement from evening to morning, while the OSA group did not. In contrast, we did not observe differences between the groups in offline changes in sequence-specific learning. Our findings suggest that disrupted sleep in OSA differently affects neural circuits involved in the consolidation of sequence learning

Symptoms of sleep breathing disorders in children are underreported by parents at general practice visits

The original publication is available at www.springerlink.comSleep breathing disorders (SBD) in children are reportedly underdiagnosed in general practice. A contributory factor may be parental underreporting of symptoms. This possibility was examined by comparing the frequency with which snoring was mentioned at general practitioner visits by parents with frequency that snoring was reported on questionnaire evaluation immediately prior to consultation. We also examined the effects of age and gender on SBD symptoms. Parents of 626 children aged 0 to 16 years attending their general practitioner for sick child visits completed selected items from the Sleep Disturbance Scale for Children and the Obstructive Sleep Apnea Syndrome Expanded Childhood Questionnaire. Parents and general practitioners were also asked if snoring was discussed at the current consultation visit or at a prior consultation visit in the previous 12 months. Eighteen percent (112 of 626) of children were frequent snorers (more than three times per week), whereas 0.6 to 5.0% of children snored and had one or more additional SBD symptom suggestive of obstructive sleep apnea. SBD symptoms tended to peak in early to middle childhood with few gender differences. We found that snoring was patently underreported by parents. In the children with a history of frequent snoring on questionnaire evaluation and where the reason for the consultation visit was documented, snoring was mentioned by parents at the current consultation visit in only 8% (8 of 100) of cases and at a prior consultation visit in only 15% (15 of 100) of cases. The present findings support a need for increased parental education regarding the symptoms and clinical significance of SBD.Sarah Blunden, Kurt Lushington, Berndt Lorenzen, Johnny Wong, R. Balendran and Declan Kenned