6 research outputs found
The Antibody Targeting the E314 Peptide of Human Kv1.3 Pore Region Serves as a Novel, Potent and Specific Channel Blocker
- Author
- A Jurado Roman
- A Schmitz
- A Vasheghani-Farahani
- AE Fasth
- AJ Harvey
- AY Chiang
- B Darpo
- BC Donner
- BY Zhou
- C Beeton
- C Beeton
- C Beeton
- C Beeton
- C Poulopoulou
- C Uyttenhove
- CN Ellis
- DA Bayliss
- DC Hanson
- DS Goodin
- EC Li
- G Panyi
- G Toldi
- H Rus
- H Wulff
- H Wulff
- H Wulff
- H Wulff
- HM Brew
- J Cotton
- J Vennekamp
- Jin-Ping Liu
- JS Smolen
- K Kalman
- K Yamashita
- KF Haegele
- KG Chandy
- KG Chandy
- Kun Liu
- L Jin
- Long-Xian Cheng
- M Garcia-Calvo
- M Krakauer
- M Peter Jr
- MA Belmonte
- MD Cahalan
- MD Cahalan
- MD Cahalan
- MD Drici
- MD Lanigan
- MH Otten
- Min Wang
- MW Pennington
- N Decher
- N Srairi-Abid
- P Azam
- P Ehling
- P Kivisakk
- PV Gardiner
- Qiu-Tang Zeng
- RR Shah
- RS Lewis
- S Markovic-Plese
- S Rangaraju
- SB Bodendiek
- SB Long
- SB Long
- SL Smart
- SO Schonland
- Sven G. Meuth
- SZ Xu
- T Dorner
- TE DeCoursey
- V Viglietta
- Xiang Gao
- Xiao-Fang Yang
- Xiao-Wei Li
- Y Matsushita
- Yan-Fu Wang
- Yi-Tian Lian
- Yong Yang
- YR Ren
- Yu-Hua Liao
- Z Varga
- Zhao-Hui Wang
- Publication venue
- Public Library of Science
- Publication date
- 27/04/2012
- Field of study
Selective blockade of Kv1.3 channels in effector memory T (TEM) cells was validated to ameliorate autoimmune or autoimmune-associated diseases. We generated the antibody directed against one peptide of human Kv1.3 (hKv1.3) extracellular loop as a novel and possible Kv1.3 blocker. One peptide of hKv1.3 extracellular loop E3 containing 14 amino acids (E314) was chosen as an antigenic determinant to generate the E314 antibody. The E314 antibody specifically recognized 63.8KD protein stably expressed in hKv1.3-HEK 293 cell lines, whereas it did not recognize or cross-react to human Kv1.1(hKv1.1), Kv1.2(hKv1.2), Kv1.4(hKv1.4), Kv1.5(hKv1.5), KCa3.1(hKCa3.1), HERG, hKCNQ1/hKCNE1, Nav1.5 and Cav1.2 proteins stably expressed in HEK 293 cell lines or in human atrial or ventricular myocytes by Western blotting analysis and immunostaining detection. By the technique of whole-cell patch clamp, the E314 antibody was shown to have a directly inhibitory effect on hKv1.3 currents expressed in HEK 293 or Jurkat T cells and the inhibition showed a concentration-dependence. However, it exerted no significant difference on hKv1.1, hKv1.2, hKv1.4, hKv1.5, hKCa3.1, HERG, hKCNQ1/hKCNE1, L-type Ca2+ or voltage-gated Na+ currents. The present study demonstrates that the antibody targeting the E314 peptide of hKv1.3 pore region could be a novel, potent and specific hKv1.3 blocker without affecting a variety of closely related Kv1 channels, KCa3.1 channels and functional cardiac ion channels underlying central nervous systerm (CNS) disorders or drug-acquired arrhythmias, which is required as a safe clinic-promising channel blocker
Deficiency of CD8 +
- Author
- Amyes E
- Ascherio A
- Bach M-A
- Booss J
- Casey MM Pfluger
- Cepok S
- Compston A
- Craig JC
- Farber DL
- Geginat J
- Haegele KF
- Haegert DG
- Khanna R
- Kreuzfelder E
- Lassmann H
- Lindsey JW
- McFarland RD
- Michael P Pender
- Michałowska-Wender G
- Mikulkova Z
- Pender MP
- Pender MP
- Pender MP
- Pender MP
- Pender MP
- Peter A Csurhes
- Reinherz EL
- Sallusto F
- Scott R Burrows
- Thompson AJ
- Thorley-Lawson DA
- Tran A
- Trotter JL
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Impact of Age on Multiple Sclerosis Disease Activity and Progression
- Author
- AM Weideman
- B Klein
- B Runmarker
- B Stankoff
- B Stankoff
- B Zeydan
- B Zeydan
- B Zeydan
- B Zeydan
- BD Trapp
- BM Keegan
- C Bjartmar
- C Bolton
- C Confavreux
- C Confavreux
- C Confavreux
- C Zhao
- CJ Azevedo
- CJ Azevedo
- D Baroncini
- D Cadavid
- DA Duszczyszyn
- E Sechi
- EB Gold
- EJ Fox
- F Ladeira
- F Schweitzer
- G Pawelec
- GL Hinks
- H Lassmann
- H Zhang
- JA Matias-Guiu
- JM Frischer
- JM Frischer
- JM Rist
- JZ Guan
- KF Haegele
- L Kappos
- LT Westlye
- M Koch
- M Novotna
- M Thewissen
- M Tutuncu
- M Veronese
- MM Paz Soldan
- N Claes
- OH Kantarci
- OH Kantarci
- P Faria Dde
- P Holmqvist
- P Stepensky
- R Bove
- R Bove
- R Bove
- R Smith
- RA Marrie
- S Hickman
- S Ramos
- SD Harlow
- SM Hayes
- T Daltrozzo
- Y Sonobe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk
- Author
- A Bahubeshi
- A Faggad
- A Milani
- AD Haegele
- AM Strubberg
- AS Devasthanam
- B Conne
- BD Adams
- BM Ryan
- BP Chew
- BP Chew
- BS Cobb
- C Faber
- DA Hill
- DC McMillan
- E Bernstein
- E Bernstein
- E Huntzinger
- F Levi
- FA Haggar
- G Rumi Jr
- GA Calin
- GJ Handelman
- H Persson
- I Slade
- J Clague
- J Ferlay
- J He
- J Molnar
- J Satia-Abouta
- J Stratmann
- JD Ribaya-Mercado
- JM Kim
- JM Shikany
- K Muller
- KA Schultz
- KF Tang
- KJ Dedes
- KW Jung
- L Witkowski
- LX Zhang
- M Leenders
- ML Slattery
- ML Slattery
- MR Friedlander
- MS Iliou
- MS Kumar
- MS Kumar
- MS Lu
- N Malila
- P Terry
- S Jung
- S Mannisto
- S Nair
- S Sekine
- SB Astley
- SH Cho
- SM Enger
- SR Carmody
- T Fukagawa
- T Narisawa
- T Rio Frio
- V Ambros
- W Shan
- X Li
- Y Ahn
- Y Chaiter
- Y Horikawa
- Y Okuyama
- Y Park
- Y Peng
- Y Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Alternative splicing in multiple sclerosis and other autoimmune diseases
- Author
- Allamargot C
- Anjos SM
- Atamas SP
- Bagos PG
- Barcellos LF
- Blond J-L
- Bonnevie-Nielsen V
- Boxall S
- Boyle LH
- Brenner T
- Carreno BM
- Carstens RP
- Chen Z
- Christensen T
- Cocco E
- Coyle PK
- Croft DR
- Delarasse C
- Diez J
- Douglas KB
- Duquette P
- Fedetz M
- Goldstrohm AC
- Gomez-Lira M
- Goodwin RG
- Graham RR
- Gregory SG
- Grigoriadis N
- Grigoryev YA
- Gu M
- Gu M
- Haegele KF
- Hasegawa M
- Hitomi Y
- Holmes N
- Irina Evsyukova
- Jacobsen M
- Jacobsen M
- Jason A. Somarelli
- Jurica MS
- Kantarci OH
- Karabon L
- Kissler S
- Klein L
- Kojo S
- Korte A
- Kotake S
- Kozyrev SV
- Kristiansen OP
- Lahita RG
- Lainez B
- Leigh Field L
- Ligers A
- Ligers A
- Liu GZ
- Lundmark F
- Lunemann JD
- Lynch KW
- Lynch KW
- Magistrelli G
- Mamegano K
- Mariano A. Garcia-Blanco
- Mazzucchelli R
- McCart AE
- McKay FC
- Michel J
- Miterski B
- Mueller SN
- Naor D
- Ng B
- Oaks MK
- Onouchi Y
- Palacios R
- Patel AA
- Pawlak E
- Perkins D
- Pribyl TM
- Pribyl TM
- Pribyl TM
- Qu H-Q
- Qu HQ
- Rider LG
- Roxburgh RH
- Ryder SP
- Sakkas LI
- Sestak AL
- Shiozawa K
- Shiryaev SA
- Simon G. Gregory
- Smyth DJ
- Sussman JD
- Szolnoki Z
- Tchilian EZ
- Tessier M-C
- The International Multiple Sclerosis Genetics Consortium
- Tsuzaka K
- Tsuzaka K
- Tsuzaka K
- Tycowski KT
- Ueda H
- Vambutas A
- Van Veen T
- Vorechovsky I
- Wang E
- Wang E
- Wang E
- Wang E
- Wang G-S
- Wang H-Y
- Ward V
- Wei C-C
- Wibulswas A
- Wu JI
- Wu Z
- Yang D
- Yasuda S
- Zhao L
- Publication venue
- Landes Bioscience
- Publication date
- Field of study
Alternative splicing is a general mechanism for regulating gene expression that affects the RNA products of more than 90% of human genes. Not surprisingly, alternative splicing is observed among gene products of metazoan immune systems, which have evolved to efficiently recognize pathogens and discriminate between “self” and “non-self”, and thus need to be both diverse and flexible. In this review we focus on the specific interface between alternative splicing and autoimmune diseases, which result from a malfunctioning of the immune system and are characterized by the inappropriate reaction to self-antigens. Despite the widespread recognition of alternative splicing as one of the major regulators of gene expression, the connections between alternative splicing and autoimmunity have not been apparent. We summarize recent findings connecting splicing and autoimmune disease, and attempt to find common patterns of splicing regulation that may advance our understanding of autoimmune diseases and open new avenues for therapy
Organolead Compounds
- Author
- A Andeli
- A Astiglioni
- A Bellomo
- A Berezniak
- A Betta
- A Blumenthal
- A Boulard de
- A Burg
- A Cahours
- A Cahours
- A Cahours
- A Cahours
- A Demidowicz
- A D’Ulivo
- A Egerton
- A Egerton
- A Egerton
- A Egerton
- A Egerton
- A Egerton
- A Egerton
- A Egerton
- A Egerton
- A Febo
- A Febo
- A Ferro
- A Fookson
- A Ghira
- A Ghira
- A Girelli
- A Goldberg
- A GrĂĽnwald
- A GrĂĽnwald
- A Hager
- A Hager
- A Hager
- A Hager
- A Hamilton
- A Imhausen
- A Imhausen
- A Ivanov
- A Jennen
- A Kaufman
- A Klein
- A Klein
- A Klein
- A Klein
- A Laveskog
- A Laveskog
- A Malatesta
- A Marroni
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morelli
- A Morgan
- A Morgan
- A Richard
- A Richard
- A Richard
- A Rieche
- A Rizzoli
- A Rizzoli
- A Ross
- A Salemi
- A Sokolik
- A Terenin
- A Terenin
- A Terenin
- A Terenin
- A Terenin
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- A Vardanis
- A Zanker
- A Zscharn
- A.L. Gol’dshtein
- AA Dobrinskaja
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- AA Gureev
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- R Barbieri
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- R Moss
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- R Nassar
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- R Robinson
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- RA Kehoe
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- S Banerjee
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- S Fukuzumi
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- S Geraci
- S Hancock
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- S Hatta
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- S Kosmider
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- V Kabaivanov
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- VA Green
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- VA Shushunov
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- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
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- VA Smith
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- VI Faerman
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- VK Khairullin
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- VP Finelonov
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- VV Korshak
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- W Bai
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- WL Richardson
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- WN Ipatiew
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- WR Law
- WR Ormandy
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- WRA Jonghe De
- WRA Jonghe De
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- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRF Notten
- WS Levine
- WT Lyn
- WT Sturges
- WV Steele
- WW Parker
- WW Parker
- WW Parker
- WW Woessner
- X Liebl
- X Xiaoding
- X Xiaoding
- X Xiaoding
- Y Aleksandrov
- Y Kaneko
- Y Marumo
- Y Mayor
- Y Miah
- Y Miah
- Y Mizoi
- Y Sayato
- Y Shao
- Y Ta
- Y Ta
- Y Ta
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Vasilenko
- Y Wakuri
- Y Yamamoto
- Y Yamamura
- Y Yamamura
- Y Yamamura
- Y Yonekawa
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Alexandrov
- YA Alexandrov
- YD Semchikov
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YM Zinov’ev
- YM Zinov’ev
- YS Drugov
- YV Zhigailo
- Z Aneva
- Z Drabent
- Z Drabent
- Z Drabent
- Z Florjanczyk
- Z Forycki
- Z Karny
- Z Kowalski
- Z Kozarzewska
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- ZK Lynkina
- ZM Manulkin
- ZM Manulkin
- ZM Manulkin
- ZM Manulkin
- ZV Veksler
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study