16 research outputs found
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts
In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, the literature in this field was scanned and results were analysed quantitatively to find the contribution of the pure compound to the activity of the whole extract. It was found that, generally, the activity of isolated molecules could not account on their own for the activity of the crude extract. It is suggested that future research should take into account the “drugs beside the drug”, looking for those products (otherwise discarded along the fractionation process) able to boost the activity of isolated active compounds
Analysis of Monoterpenoid Indole Alkaloids Using Electrospray Ionization Tandem Mass Spectrometry
Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids
Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre
General Approach for the Synthesis of Sarpagine/Macroline Indole Alkaloids. Enantiospecific Total Synthesis of the Indole Alkaloid Trinervine
Ethnobotany study of Dayak society medicinal plants utilization in Uut Murung District, Murung Raya Regency, Central Kalimantan
Components of Stem Barks of Winchia calophylla A. DC. and Their Bronchodilator Activities
Oxidative Burst Inhibitory and Cytotoxic Indoloquinazoline and Furoquinoline Alkaloids from Oricia suaveolens
Wansi J, Mesaik MA, Chiozem DD, et al. Oxidative Burst Inhibitory and Cytotoxic Indoloquinazoline and Furoquinoline Alkaloids from Oricia suaveolens. Journal of Natural Products. 2008;71(11):1942-1945.Two new beta-indoloquinazoline alkaloids, orisuaveoline A (1) and orisuaveoline B (2), two new furoquinoline alkaloids, quinosuaveoline A (5) and quinosuaveoline B (6), and 12 known compounds were isolated from Oricia suaveolens. The structures of the new compounds were deduced by spectroscopic studies. The absolute configuration of nkolbisine (4) was also determined. Compounds 2, 3, 6-8, 10, and 14 were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against A549 lung carcinoma cells