17 research outputs found
Venous gas embolism as a predictive tool for improving CNS decompression safety
A key process in the pathophysiological steps leading to decompression sickness (DCS) is the formation of inert gas bubbles. The adverse effects of decompression are still not fully understood, but it seems reasonable to suggest that the formation of venous gas emboli (VGE) and their effects on the endothelium may be the central mechanism leading to central nervous system (CNS) damage. Hence, VGE might also have impact on the long-term health effects of diving. In the present review, we highlight the findings from our laboratory related to the hypothesis that VGE formation is the main mechanism behind serious decompression injuries. In recent studies, we have determined the impact of VGE on endothelial function in both laboratory animals and in humans. We observed that the damage to the endothelium due to VGE was dose dependent, and that the amount of VGE can be affected both by aerobic exercise and exogenous nitric oxide (NO) intervention prior to a dive. We observed that NO reduced VGE during decompression, and pharmacological blocking of NO production increased VGE formation following a dive. The importance of micro-nuclei for the formation of VGE and how it can be possible to manipulate the formation of VGE are discussed together with the effects of VGE on the organism. In the last part of the review we introduce our thoughts for the future, and how the enigma of DCS should be approached
Resolution of inflammation: a new therapeutic frontier
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field
Sowing a way towards revitalizing Indigenous agriculture: creating meaning from a forum discussion in Saskatchewan, Canada
Evidence of cell damages caused by circulating bubbles: high level of free mitochondrial DNA in plasma of rats
Ascent rate, age, maximal oxygen uptake, adiposity, and circulating venous bubbles after diving
Virtual Reality as an Adjunct Home Therapy in Chronic Pain Management: An Exploratory Study
Do postoperative radiographically verified technical success, improved cosmesis, and trunk shift corroborate with patient-reported outcomes in Lenke 1C adolescent idiopathic scoliosis?
Preconditioning Methods and Mechanisms for Preventing the Risk of Decompression Sickness in Scuba Divers: A Review
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Measurement of the beam-normal single-spin asymmetry for elastic electron scattering from C12 and Al27
We report measurements of the parity-conserving beam-normal single-spin
elastic scattering asymmetries on C and Al, obtained with
an electron beam polarized transverse to its momentum direction. These
measurements add an additional kinematic point to a series of previous
measurements of on C and provide a first measurement on Al.
The experiment utilized the Qweak apparatus at Jefferson Lab with a beam energy
of 1.158 GeV. The average lab scattering angle for both targets was 7.7
degrees, and the average for both targets was 0.02437 GeV (Q=0.1561
GeV). The asymmetries are = -10.68 0.90 stat) 0.57 (syst) ppm
for C and = -12.16 0.58 (stat) 0.62 (syst) ppm for
Al. The results are consistent with theoretical predictions, and are
compared to existing data. When scaled by Z/A, the Q-dependence of all the
far-forward angle (theta < 10 degrees) data from H to Al can be
described by the same slope out to GeV. Larger-angle data from
other experiments in the same Q range are consistent with a slope about twice
as steep