Calcineurin-Inhibitor Minimization in Liver Transplant Patients with Calcineurin-Inhibitor-Related Renal Dysfunction: A Meta-Analysis

BACKGROUND: Introduction of calcineurin-inhibitor (CNI) has made transplantation a miracle in the past century. However, the side effects of long-term use of CNI turn out to be one of the major challenges in the current century. Among these, renal dysfunction attracts more and more attention. Herein, we undertook a meta-analysis to evaluate the efficacy and safety of calcineurin-inhibitor (CNI) minimization protocols in liver transplant recipients with CNI-related renal dysfunction. METHODS: We included randomized trials with no year and language restriction. All data were analyzed using random effect model by Review Manager 5.0. The primary endpoints were glomerular filtration rate (GFR), serum creatinine level (sCr) and creatinine clearance rate (CrCl), and the secondary endpoints were acute rejection episodes, incidence of infection and patient survival at the end of follow-up. RESULTS: GFR was significantly improved in CNI minimization group than in routine CNI regimen group (Z = 5.45, P<0.00001; I(2) = 0%). Likely, sCr level was significantly lower in the CNI minimization group (Z = 2.84, P = 0.005; I(2) = 39%). However, CrCl was not significantly higher in the CNI minimization group (Z = 1.59, P = 0.11; I(2) = 0%). Both acute rejection episodes and patient survival were comparable between two groups (rejection: Z = 0.01, P = 0.99; I(2) = 0%; survival: Z = 0.28, P = 0.78; I(2) = 0%, respectively). However, current CNI minimization protocols may be related to a higher incidence of infections (Z = 3.06, P = 0.002; I(2) = 0%). CONCLUSION: CNI minimization can preserve or even improve renal function in liver transplant patients with renal impairment, while sharing similar short term acute rejection rate and patient survival with routine CNI regimen

Design for Mobile Mental Health:An Exploratory Review

A large number of mobile mental health apps are available to the public but current knowledge about requirements of designing such solutions is scarce, especially from sociotechnical and user centred points of view. Due to the significant role of mobile apps in the mental health service models, identifying the design requirements of mobile mental health solutions is crucial. Some of those requirements have been addressed individually in the literature, but there are few research studies that show a comprehensive picture of this domain. This exploratory review aims to facilitate such holistic understanding. The main search keywords of the review were identified in a cross-disciplinary requirements workshop. The search was started by finding some core references in the healthcare databases. A wider range of references then has been explored using a snowball method. Findings showed that there is a good understanding of individual design requirements in current literature but there are few examples of implementing a combination of different design requirements in real world products. The design processes specifically developed for mobile mental health apps are also rare. Most studies on operational mobile mental health apps address major mental health issues while prevention and wellbeing areas are underdeveloped. In conclusion, the main recommendations for designing future mobile mental health solutions include: moving towards sociotechnical and open design strategies, understanding and creating shared value, recognizing all dimensions of efficacy, bridging design and medical research and development, and considering an ecosystem perspective

Frequência fundamental de crianças da cidade de Niterói Fundamental frequency for children in the municipality of Niterói

OBJETIVO: medir a frequência fundamental de 122 crianças de seis a oito anos de idade, meninos e meninas, sem alterações vocais, avaliadas por meio da escala Rasat. MÉTODOS: a análise perceptivo-auditiva foi realizada através da escala RASAT e para a análise acústica computadorizada foi utilizado o programa de software Vox Metria, analisando-se a média da frequência fundamental de amostras da vogal [&#949;] sustentada. Participaram deste estudo 122 crianças, 58 meninos e 64 meninas com idade variando de seis a oito anos e 11 meses de idade do ensino fundamental, da Rede Municipal de Niterói-RJ, nascidos e residentes na cidade, pré-selecionadas através de um protocolo de triagem. RESULTADOS: os resultados obtidos neste estudo foram: frequência fundamental média de 239,60 Hz para as meninas e 237,17 Hz para os meninos, obtendo-se uma média geral de 238,44 Hz. CONCLUSÃO: conclui-se que os achados permitiram a comparação com resultados de pesquisas realizadas anteriormente, contribuindo com novos dados para a padronização da frequência fundamental das vozes infantis brasileiras.<br>PURPOSE: to quantify the fundamental frequency in a group of 122 children - boys and girls, whose age varied from six to eight-year-old, who do not have vocal alterations. METHODS: an auditory-perceptive analysis took place by means of the RASAT scale; the computerized acoustic analysis was performed by using a software referred to as Vox Metria, where samples regarding the mean value for the fundamental frequency of the sustained vowel [&#949;] were analyzed. For this study, in which 122 children took part, 58 boys and 64 girls, with ages ranging from 6 to 8-year and 11 months. They were students from the Elementary Schools of the Municipal Education System of Niteroi-RJ. They were born and reside in this municipality and were pre-selected by means of a choice protocol. RESULTS: the results obtained in this study were 239.60 Hz for the girls and 237.17 Hz for the boys, with an overall mean value of 238.44 Hz. Due to the small difference; we obtained 237.57 Hz for the girls and 233.31 Hz for the boys. CONCLUSION: the findings enabled the comparison with previously carried out research and contributed providing the literature with new data for the standardization of the fundamental frequency of Brazilian Children's Voices, opening a new channel for further research