91 research outputs found
Resolved Sideband Cooling of a Micromechanical Oscillator
Micro- and nanoscale opto-mechanical systems provide radiation pressure
coupling of optical and mechanical degree of freedom and are actively pursued
for their ability to explore quantum mechanical phenomena of macroscopic
objects. Many of these investigations require preparation of the mechanical
system in or close to its quantum ground state. Remarkable progress in ground
state cooling has been achieved for trapped ions and atoms confined in optical
lattices. Imperative to this progress has been the technique of resolved
sideband cooling, which allows overcoming the inherent temperature limit of
Doppler cooling and necessitates a harmonic trapping frequency which exceeds
the atomic species' transition rate. The recent advent of cavity back-action
cooling of mechanical oscillators by radiation pressure has followed a similar
path with Doppler-type cooling being demonstrated, but lacking inherently the
ability to attain ground state cooling as recently predicted. Here we
demonstrate for the first time resolved sideband cooling of a mechanical
oscillator. By pumping the first lower sideband of an optical microcavity,
whose decay rate is more than twenty times smaller than the eigen-frequency of
the associated mechanical oscillator, cooling rates above 1.5 MHz are attained.
Direct spectroscopy of the motional sidebands reveals 40-fold suppression of
motional increasing processes, which could enable reaching phonon occupancies
well below unity (<0.03). Elemental demonstration of resolved sideband cooling
as reported here should find widespread use in opto-mechanical cooling
experiments. Apart from ground state cooling, this regime allows realization of
motion measurement with an accuracy exceeding the standard quantum limit.Comment: 13 pages, 5 figure
Stimulated optomechanical excitation of surface acoustic waves in a microdevice
Stimulated Brillouin interaction between sound and light, known to be the
strongest optical nonlinearity common to all amorphous and crystalline
dielectrics, has been widely studied in fibers and bulk materials but rarely in
optical microresonators. The possibility of experimentally extending this
principle to excite mechanical resonances in photonic microsystems, for sensing
and frequency reference applications, has remained largely unexplored. The
challenge lies in the fact that microresonators inherently have large free
spectral range, while the phase matching considerations for the Brillouin
process require optical modes of nearby frequencies but with different
wavevectors. We rely on high-order transverse optical modes to relax this
limitation. Here we report on the experimental excitation of mechanical
resonances ranging from 49 to 1400 MHz by using forward Brillouin scattering.
These natural mechanical resonances are excited in ~100 um silica microspheres,
and are of a surface-acoustic whispering-gallery type
Demonstration of an ultracold micro-optomechanical oscillator in a cryogenic cavity
Preparing and manipulating quantum states of mechanical resonators is a
highly interdisciplinary undertaking that now receives enormous interest for
its far-reaching potential in fundamental and applied science. Up to now, only
nanoscale mechanical devices achieved operation close to the quantum regime. We
report a new micro-optomechanical resonator that is laser cooled to a level of
30 thermal quanta. This is equivalent to the best nanomechanical devices,
however, with a mass more than four orders of magnitude larger (43 ng versus 1
pg) and at more than two orders of magnitude higher environment temperature (5
K versus 30 mK). Despite the large laser-added cooling factor of 4,000 and the
cryogenic environment, our cooling performance is not limited by residual
absorption effects. These results pave the way for the preparation of 100-um
scale objects in the quantum regime. Possible applications range from
quantum-limited optomechanical sensing devices to macroscopic tests of quantum
physics.Comment: Published versio
Carotid endarterectomy and carotid artery stenting utilization trends over time
<p>Abstract</p> <p>Background</p> <p>Carotid endarterectomy (CEA) has been the standard in atherosclerotic stroke prevention for over 2 decades. More recently, carotid artery stenting (CAS) has emerged as a less invasive alternative for revascularization. The purpose of this study was to investigate whether an increase in stenting parallels a decrease in endarterectomy, if there are specific patient factors that influence one intervention over the other, and how these factors may have changed over time.</p> <p>Methods</p> <p>Using a nationally representative sample of US hospital discharge records, data on CEA and CAS procedures performed from 1998 to 2008 were obtained. In total, 253,651 cases of CEA and CAS were investigated for trends in utilization over time. The specific data elements of age, gender, payer source, and race were analyzed for change over the study period, and their association with type of intervention was examined by multiple logistic regression analysis.</p> <p>Results</p> <p>Rates of intervention decreased from 1998 to 2008 (P < 0.0001). Throughout the study period, endarterectomy was the much more widely employed procedure. Its use displayed a significant downward trend (P < 0.0001), with the lowest rates of intervention occurring in 2007. In contrast, carotid artery stenting displayed a significant increase in use over the study period (P < 0.0001), with the highest intervention rates occurring in 2006. Among the specific patient factors analyzed that may have altered utilization of CEA and CAS over time, the proportion of white patients who received intervention decreased significantly (P < 0.0001). In multivariate modeling, increased age, male gender, white race, and earlier in the study period were significant positive predictors of CEA use.</p> <p>Conclusions</p> <p>Rates of carotid revascularization have decreased over time, although this has been the result of a reduction in CEA despite an overall increase in CAS. Among the specific patient factors analyzed, age, gender, race, and time were significantly associated with the utilization of these two interventions.</p
Loss of LMO4 in the Retina Leads to Reduction of GABAergic Amacrine Cells and Functional Deficits
BACKGROUND: LMO4 is a transcription cofactor expressed during retinal development and in amacrine neurons at birth. A previous study in zebrafish reported that morpholino RNA ablation of one of two related genes, LMO4b, increases the size of eyes in embryos. However, the significance of LMO4 in mammalian eye development and function remained unknown since LMO4 null mice die prior to birth. METHODOLOGY/PRINCIPAL FINDINGS: We observed the presence of a smaller eye and/or coloboma in ∼40% LMO4 null mouse embryos. To investigate the postnatal role of LMO4 in retinal development and function, LMO4 was conditionally ablated in retinal progenitor cells using the Pax6 alpha-enhancer Cre/LMO4flox mice. We found that these mice have fewer Bhlhb5-positive GABAergic amacrine and OFF-cone bipolar cells. The deficit appears to affect the postnatal wave of Bhlhb5+ neurons, suggesting a temporal requirement for LMO4 in retinal neuron development. In contrast, cholinergic and dopaminergic amacrine, rod bipolar and photoreceptor cell numbers were not affected. The selective reduction in these interneurons was accompanied by a functional deficit revealed by electroretinography, with reduced amplitude of b-waves, indicating deficits in the inner nuclear layer of the retina. CONCLUSIONS/SIGNIFICANCE: Inhibitory GABAergic interneurons play a critical function in controlling retinal image processing, and are important for neural networks in the central nervous system. Our finding of an essential postnatal function of LMO4 in the differentiation of Bhlhb5-expressing inhibitory interneurons in the retina may be a general mechanism whereby LMO4 controls the production of inhibitory interneurons in the nervous system
A long non-coding RNA links calreticulin-mediated immunogenic cell removal to RB1 transcription
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems
Prediction of phycoremediation of As(III) and As(V) from synthetic wastewater by Chlorella pyrenoidosa using artificial neural network
Properties of Neon, Magnesium, and Silicon Primary Cosmic Rays Results from the Alpha Magnetic Spectrometer
We report the observation of new properties of primary cosmic rays, neon (Ne), magnesium (Mg), and silicon (Si), measured in the rigidity range 2.15 GV to 3.0 TV with 1.8 x 10(6) Ne, 2.2 x 10(6) Mg, and 1.6 x 10(6) Si nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. The Ne and Mg spectra have identical rigidity dependence above 3.65 GV. The three spectra have identical rigidity dependence above 86.5 GV, deviate from a single power law above 200 GV, and harden in an identical way. Unexpectedly, above 86.5 GV the rigidity dependence of primary cosmic rays Ne, Mg, and Si spectra is different from the rigidity dependence of primary cosmic rays He, C, and O. This shows that the Ne, Mg, and Si and He, C, and O are two different classes of primary cosmic rays
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