A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug discovery methods under the same experimental conditions. Collecting compound lists derived from various methods is advantageous for aggregating compounds with structurally diversified properties compared with the use of a single method. The inhibitory action on Sirtuin 1 of approximately half of the proposed compounds was experimentally accessed. Ultimately, seven structurally diverse compounds were identified

Feasibility investigation for a bridge damage identification method through moving vehicle laboratory experiment

This paper investigated the feasibility of the pseudo-static damage identification method derived from a bridge–vehicle interaction system through a moving vehicle laboratory experiment. The element stiffness index, defined as the ratio of flexural rigidity of a damaged member to that of an intact member, serves as the damage indicator. Three vehicle models and two travelling speeds were considered in the experiment to examine the effect of vehicle's dynamic characteristic and travelling speed on identified results. It is demonstrated that locations and severities of damages are detectable using the proposed method in spite of the probable changes of roadway roughness and environmental conditions. In addition, adopting higher vehicle speed as well as the vehicle with frequency close to that of the bridge increased the probability of detecting damages