ANTI ACNE ACTIVITY OF ACETONE EXTRACT OF PLUMBAGO INDICA ROOT

AbstractAcne is the most common disorder of skin. Approximately 85 % of all adolescents suffer from acne and 30% of them used pharmaceutical however remaining population rely on traditional medicine for cure of acne. In present study an attempt has been taken to investigate the in vitro anti‑acne activity of acetone extract of root of Plumbago indica. The antiacne activity was investigated against two acne causing bacteria, i.e., Propionibacterium acne and Staphylococcus epidermidis and yeast Malassezia furfur by well diffusion method.  The result showed that drugs was active against all microorganism. The Minimum inhibitory concentration of the P. indica root extract against test P. Acne, S. Epidermidis and M.furfur was found to be 600µg/ml, 200 µg/ml and 300µg/ml respectively. However the extract acts in dose dependent manner against causative microorganism.Result suggests that P.indica has potential activity against acne causing microorganism and hence this can be used in topical anti‑acne preparations.Key words: Plumbago indica, Acne, Propionibacterium acnes, Staphylococcus epidermidis, Malassezia furfur, Skin disorder

Coupling the effect of mental practice and Pilates on ambulation of individuals with multiple sclerosis: Five case studies

Pilates, a popular form of exercise, greatly emphasizes on the strengthening of the core muscles; however, the efficacy of exercise program can be impaired in patients with cognitive impairments. To bridge this gap, mental practice of a desired task can help to mentally simulate a given action and retain many properties of the corresponding real action. This study tries to gain preliminary understanding on the effectiveness of the combination of mental practice and core-strengthening Pilates exercises. To explore the effectiveness of mental practice and Pilates-based training on core strength, balance and mobility in multiple sclerosis (MS) patients. This study highlights a single center case series describing the outcomes in ambulant patients with MS treated with mental practice and Pilates. Five volunteer ambulant individuals with stable relapsing-remitting MS participated in 20 individualized sessions, spread over 10-week duration. Pilates with mental practice session was delivered by a physiotherapist. Each session comprised 20 min of mental practice followed by 40 min of core-strengthening Pilates exercises. All the included patients were screened with Movement Imagery Questionnaire-Revised Second Version to determine if they are were able to effectively engage in imagery practice. A range of outcomes were measured: Timed up and go, chair stand test, curl-ups, the abdominal angle through leg raises, and the Activities-specific Balance Confidence Scale before and after the intervention. Group data analysis indicated significant improvement between baseline and post-intervention phases for all the tested parameters. This study provides preliminary insight into this novel combination technique to improve balance and mobility in ambulant people with MS. Mental practice played an important role in keeping the patient's compliance, which was analyzed through structured interviews. Variations in response to the intervention are evident