Primordialists and Constructionists: a typology of theories of religion

This article adopts categories from nationalism theory to classify theories of religion. Primordialist explanations are grounded in evolutionary psychology and emphasize the innate human demand for religion. Primordialists predict that religion does not decline in the modern era but will endure in perpetuity. Constructionist theories argue that religious demand is a human construct. Modernity initially energizes religion, but subsequently undermines it. Unpacking these ideal types is necessary in order to describe actual theorists of religion. Three distinctions within primordialism and constructionism are relevant. Namely those distinguishing: a) materialist from symbolist forms of constructionism; b) theories of origins from those pertaining to the reproduction of religion; and c) within reproduction, between theories of religious persistence and secularization. This typology helps to make sense of theories of religion by classifying them on the basis of their causal mechanisms, chronology and effects. In so doing, it opens up new sightlines for theory and research

Bioenergy Watershed Restoration in Regions of the West: What are the Environmental/Community Issues?

Throughout the western mountainous regions, wildfire risks are elevated due to both fire suppression activities which have changed the forest structure making it more susceptible to stand-killing fires and the expansion of human structures (houses, light commercial) into these same forests, By providing a market for currently noncommercial but flammable materials (small trees, tops, and branches), new and existing bioenergy industries could be a key factor in reducing the regional forest fuel loads. Although bioenergy would appear to be an ideal answer to the problem in many ways, the situation is complicated and numerous issues need resolution. A public fearful of logging in these regions needs assurance that harvesting for bioenergy is an environmentally and socially responsible solution to the current fuel build up in these forests. This is especially important given that biomass harvesting cannot pay its own way under current energy market conditions and would have to be supported in some fashion

Variation in Energy Expenditure among Black‐Legged Kittiwakes):Effects of Activity‐Specific Metabolic Rates and Activity Budgets

We sought to determine the effect of variation in time‐activity budgets (TABs) and foraging behavior on energy expenditure rates of parent black‐legged kittiwakes (Rissa tridactyla). We quantified TABs using direct observations of radio‐tagged adults and simultaneously measured field metabolic rates (FMR) of these same individuals (n = 20) using the doubly labeled water technique. Estimated metabolic rates of kittiwakes attending their brood at the nest or loafing near the colony were similar (ca. 1.3 × basal metabolic rate [BMR]), although loafing during foraging trips was more costly (2.9 × BMR). Metabolic rates during commuting flight (7.3 × BMR) and prey‐searching flight (6.2 × BMR) were similar, while metabolic rates during plunge diving were much higher (ca. 47 × BMR). The proportion of the measurement interval spent foraging had a positive effect on FMR (R2 = 0.68), while the combined proportion of time engaged in nest attendance and loafing near the colony had a negative effect on FMR (R2 = 0.72). Thus, more than two‐thirds of the variation in kittiwake FMR could be explained by the allocation of time among various activities. The high energetic cost of plunge diving relative to straight flight and searching flight suggests that kittiwakes can optimize their foraging strategy under conditions of low food availability by commuting long distances to feed in areas where gross foraging efficiency is high

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

Background: Src signaling is markedly upregulated in patients with invasive glioblastoma (GBM) after the administration of bevacizumab. The Src family kinase inhibitor dasatinib has been found to effectively block bevacizumab-induced glioma invasion in preclinical models, which led to the hypothesis that combining bevacizumab with dasatinib could increase bevacizumab efficacy in patients with recurrent GBM. Methods: After the completion of the phase 1 component, the phase 2 trial (ClinicalTrials.gov identifier NCT00892177) randomized patients with recurrent GBM 2:1 to receive 100 mg of oral dasatinib twice daily (arm A) or placebo (arm B) on days 1 to 14 of each 14-day cycle combined with 10 mg/kg of intravenous bevacizumab on day 1 of each 14-day cycle. The primary endpoint was 6-month progression-free survival (PFS6). Results: In the 121 evaluable patients, the PFS6 rate was numerically, but not statistically, higher in arm A versus arm B (28.9% [95% CI, 19.5%-40.0%] vs 18.4% [95% CI, 7.7%-34.4%]; P =.22). Similarly, there was no significant difference in the median overall survival noted between the treatment arms (7.3 months and 7.7 months, respectively; P =.93). The objective response rate was 15.7% in arm A and 26.3% in arm B (P =.52), but with a significantly longer duration in patients treated on arm A (16.3 months vs 2 months). The incidence of grade 653 toxicity was comparable between treatment arms, with hematologic toxicities occurring more frequently in arm A versus arm B (15.7% vs 7.9%) (adverse events were assessed as per the National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]). Correlative tissue analysis demonstrated an association between pSRC/LYN signaling in patient tumors and outcome. Conclusions: Despite upregulation of Src signaling in patients with GBM, the combination of bevacizumab with dasatinib did not appear to significantly improve the outcomes of patients with recurrent GBM compared with bevacizumab alone