Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functions

13301甲第4518号博士（医学）金沢大学博士論文本文Full 以下に掲載：Molecular Medicine Reports 16(1) pp.873-880 2017. SPANDIDOS PUBLICATIONS UK LTD. 共著者：MIDORI KATSUYAMA, MASASHI DEMURA, HIRONOBU KATSUYAMA, HIDEJI TANII, KIYOFUMI SAIJO

Tuberculosis Suspect in the Companies in Semarang District Indonesia; Case-Control Study

In Semarang district, the population at the companies were 83120 workers. The number of smear positive cases in 2011 were 258 and 3898 suspected tuberculosis. Case-control study was conducted to analyze the risk of TB suspect infection among workers in the factory. We recruited 194 suspects and 197 controls who visited the factory clinic. The most common symptom was coughing with sputum (63 %) and then followed by malaise, chest pain, sweating at night, weight loss, dyspnea, anorexia, cough more than 2 weeks, sub febris and hemoptoe. Around 47 % both of the suspects and controls don't know received Bacillus Calmette-guérin (BCG) or not. The multivariate analysis showed the dominant factors that influence the occurrence of TB suspect, “education”, “income”, “ashamed of having TB”, “TB treatment is very costly”, and “share dish”.distribution of health education booklet to teachers and parents

Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people

Abstract Background A man-made chemical disaster occurred in the Amur River, leading to posttraumatic stress disorder (PTSD) in the Nanai people indigenous to the river’s surrounding area. PTSD severity measured by the total scores of Impact of Event Scale-Revised (IES-R) (Total-I) and Clinician-Administered PTSD Scale (CAPS) (Total-C) were not always identical in terms of demographic and ethnocultural characters. It is possible that the results derived using the Total-I and Total-C may differ for persons with different backgrounds and/or individual characteristics. In this study, the associations between PTSD severity and personal characteristics were evaluated. Methods The study was a field-type survey including 187 randomly selected participants (75 males and 112 females). In addition to Total-I/Total-C, scores for each IES-R/CAPS item, Intrusion, Avoidance, and Hyperarousal, and Ego Structure Test by Ammon (ISTA) score were examined to evaluate their personal characteristics. Results No specific trends in ISTA score were obvious among four groups defined according to Total-I/Total-C. The results of principal component analysis showed that all IES-R/CAPS items contributed positively to the 1st axis but to the 2nd axis in a different manner. ISTA items did not always show correlations to each other, but principal component analysis suggested that Construct contributed positively and Destruct and Deficient (with the exception of Destruct sexuality) contributed negatively. High IES-R scores were associated with Construct Aggression and Deficient Inner demarcation, but high CAPS score was less likely to exhibit Construct Narcissism. Conclusion To avoid the misdiagnosis of PTSD, usage of both IES-R/CAPS may be required. Simultaneous application of personality/ego tests may be helpful, but appropriate numbers of their questions would be important

Sudden infant death due to mechanical asphyxia caused by a cervical ectopic thymus—An autopsy case

The 7-month-old girl was left in a nursery until following morning. About 3 h after being given milk, she was found dead in a right lateral supine position. There was no external evidence of injury to suggest a maltreatment. Hemorrhages were present in the accessory respiratory muscles, but the most notable findings were masses on either side of the trachea and immediately inferior to the thyroid gland. Both of masses were in continuity with the intrathoracic thymus. Histopathologically, the masses showed normal thymic structure and collagen fibers on the left side of the trachea showed metachromasia on Masson’s staining. There were no remarkable findings in organs except for congestion. The cause of death was determined to be mechanical asphyxia due to tracheal compression by the cervical ectopic thymus. Hemorrhage in the accessory respiratory muscle was considered to be caused by effortful breathing during the process of asphyxia. The metachromasia of Masson's stain on the trachea may be due to the same mechanism as a “compression mark reaction”, and may be useful in proving compression by the ectopic thymus. We consider that chronic compression of the trachea led to the tracheomalacia, which enabled the final lethal compression when lying in a right lateral supine position. An ectopic thymus is caused by a failure of descent of the embryonic thymic tissue into the thoracic cavity at the appropriate developmental stage and is generally asymptomatic. However, the cervical ectopic thymus should be considered in the diagnosis of a cause of sudden infant death

Alcohol consumption induces murine osteoporosis by downregulation of natural killer T‐like cell activity

202