5 research outputs found
Comparison between goose (anser anser) and chicken (gallus gallus domesticus) eggshells during embryonic development by scanning electron microscopy
Immunohistochemical distribituon of cox-1, cox-2, and tgfβ-1 in the duodenum of rats treated with capsaicin
Effects of kefir, koumiss, milk and yoghurt administration on distribution of plasma cells and mast cells in mice spleen
Plasma nitric oxide (no) and tumor necrosis factor-α (tnf-α) levels, adenosine deaminase (ada), gamma glutamyl transferase (ggt) activities and to determine the rate of lymphocytes in the peripheral blood leukocytes alpha naphthyl acetate esterase (anae) in cattle with leptospirosis
Geoepidemiology and clinical characteristics of neonatal lupus erythematosus: A systematic literature review of individual patients’ data
Background/aim: Neonatal lupus erythematosus (NLE) is an autoimmune syndrome caused by transplacental transmission of maternal autoantibodies, often with devastating consequences. The objective of this systematic literature review was to analyze the demographic data, geoepidemiology, clinical, and serological characteristics associated with NLE. Materials and methods: We performed a systematic literature search of the Pubmed database covering the period from 1976 to August 2015, using the MeSH terms " neonatal lupus” or “congenital heart block”. To be included in the study, articles of any type (original articles, case series, and case reports) had to report on infants with NLE on an individualized (i.e. patient-by-patient) basis. Results: A total of 198 studies were included in the review, reporting on a total of 755 NLE patients. The most frequently reported clinical manifestations of NLE were congenital heart block (CHB, 65.2%), cutaneous lupus (33.1%), and cytopenias (15.5%). We found differences in NLE characteristics based on study geographical origin, with CHB being much more frequent in patients of European or American descent (49.4% and 35%, respectively), while reports originating from Asia reported a higher prevalence of skin involvement (45.2%). Most CHB cases (72.9%) were diagnosed between the 18th and 26th week of gestation. Conclusions: Phenotypic differences of NLE depending on race and country may reflect true pathophysiologic differences or methodologic discrepancies. While maternal autoimmune disease is not a prerequisite for the development of NLE, the existence of a truly " immunonegative” CHB is questionable. © 2020, Turkiye Klinikleri. All rights reserved