How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study

Background: Memory clinic patients frequently present with different forms of vascular brain injury due to different etiologies, often co-occurring with Alzheimer’s disease (AD) pathology. / Objective: We studied how cognition was affected by different forms of vascular brain injury, possibly in interplay with AD pathology. / Methods: We included 860 memory clinic patients with vascular brain injury on magnetic resonance imaging (MRI), receiving a standardized evaluation including cerebrospinal fluid (CSF) biomarker analyses (n = 541). The cognitive profile of patients with different forms of vascular brain injury on MRI (moderate/severe white matter hyperintensities (WMH) (n = 398), microbleeds (n = 368), lacunar (n = 188) and non-lacunar (n = 96) infarct(s), macrobleeds (n = 16)) was assessed by: 1) comparison of all these different forms of vascular brain injury with a reference group (patients with only mild WMH (n = 205) without other forms of vascular brain injury), using linear regression analyses also stratified for CSF biomarker AD profile and 2) multivariate linear regression analysis. / Results: The cognitive profile was remarkably similar across groups. Compared to the reference group effect sizes on all domains were <0.2 with narrow 95% confidence intervals, except for non-lacunar infarcts on information processing speed (age, sex, and education adjusted mean difference from reference group (β: – 0.26, p = 0.05). Results were similar in the presence (n = 300) or absence (n = 241) of biomarker co-occurring AD pathology. In multivariate linear regression analysis, higher WMH burden was related to a slightly worse performance on attention and executive functioning (β: – 0.08, p = 0.02) and working memory (β: – 0.08, p = 0.04). / Conclusion: Although different forms of vascular brain injury have different etiologies and different patterns of cerebral damage, they show a largely similar cognitive profile in memory clinic patients regardless of co-occurring AD pathology

Volksgezondheid toekomst verkenning 1997 : de som der delen

In 1993 werd voor het eerst een toekomstverkenning gepubliceerd. In dat document werd een groot aantal gezondheidsgegevens over de Nederlandse bevolking in onderlinge samenhang gepresenteerd. Vier jaar later blijkt behoefte aan bijstelling van de cijfers over ziekte, gezondheid en hun oorzaken. Naast die actualisering van gegevens wordt in dit rapport ingegaan op de ongelijke verdeling van gezondheid en ziekte over jong en oud en arm en rijk. Veranderingen in de volksgezondheid treden zelden snel of schoksgewijs op. Toch zijn duidelijke trends waarneembaar: de levensverwachting blijft stijgen, ongezonde leefgewoonten (bijv. roken) nemen toe en de ziektelast wordt overheerst door chronisch lichamelijke kwalen en de psychische problematiek

How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study

Neuro Imaging Researc

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus

Neuro Imaging Researc