303 research outputs found
Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA is synthesised from L-kynurenine by kynurenine aminotransferases (KAT) I and II. A host of immune mediators influence tryptophan degradation. In the present study, the levels of KYNA in cerebrospinal fluid (CSF) and serum in a group of human subjects aged between 25 and 74 years were determined by using a high performance liquid chromatography method. In CSF and serum KAT I and II activities were investigated by radioenzymatic assay, and the levels of β2-microglobulin, a marker for cellular immune activation, were determined by ELISA. The correlations between neurochemical and biological parameters were evaluated. Two subject groups with significantly different ages, i.e. 50 years, p < 0.001, showed statistically significantly different CSF KYNA levels, i.e. 2.84 ± 0.16 fmol/μl vs. 4.09 ± 0.14 fmol/μl, p < 0.001, respectively; but this difference was not seen in serum samples. Interestingly, KYNA is synthesised in CSF principally by KAT I and not KAT II, however no relationship was found between enzyme activity and ageing. A positive relationship between CSF KYNA levels and age of subjects indicates a 95% probability of elevated CSF KYNA with ageing (R = 0.6639, p = 0.0001). KYNA levels significantly correlated with IgG and β2-microglobulin levels (R = 0.5244, p = 0.0049; R = 0.4253, p = 0.043, respectively). No correlation was found between other biological parameters in CSF or serum. In summary, a positive relationship between the CSF KYNA level and ageing was found, and the data would suggest age-dependent increase of kynurenine metabolism in the CNS. An enhancement of CSF IgG and β2-microglobulin levels would suggest an activation of the immune system during ageing. Increased KYNA metabolism may be involved in the hypofunction of the glutamatergic and/or nicotinic cholinergic neurotransmission in the ageing CNS
Inelastic collapse of a randomly forced particle
We consider a randomly forced particle moving in a finite region, which
rebounds inelastically with coefficient of restitution r on collision with the
boundaries. We show that there is a transition at a critical value of r,
r_c\equiv e^{-\pi/\sqrt{3}}, above which the dynamics is ergodic but beneath
which the particle undergoes inelastic collapse, coming to rest after an
infinite number of collisions in a finite time. The value of r_c is argued to
be independent of the size of the region or the presence of a viscous damping
term in the equation of motion.Comment: 4 pages, REVTEX, 2 EPS figures, uses multicol.sty and epsf.st
A Grassmann integral equation
The present study introduces and investigates a new type of equation which is
called Grassmann integral equation in analogy to integral equations studied in
real analysis. A Grassmann integral equation is an equation which involves
Grassmann integrations and which is to be obeyed by an unknown function over a
(finite-dimensional) Grassmann algebra G_m. A particular type of Grassmann
integral equations is explicitly studied for certain low-dimensional Grassmann
algebras. The choice of the equation under investigation is motivated by the
effective action formalism of (lattice) quantum field theory. In a very general
setting, for the Grassmann algebras G_2n, n = 2,3,4, the finite-dimensional
analogues of the generating functionals of the Green functions are worked out
explicitly by solving a coupled system of nonlinear matrix equations. Finally,
by imposing the condition G[{\bar\Psi},{\Psi}] = G_0[{\lambda\bar\Psi},
{\lambda\Psi}] + const., 0<\lambda\in R (\bar\Psi_k, \Psi_k, k=1,...,n, are the
generators of the Grassmann algebra G_2n), between the finite-dimensional
analogues G_0 and G of the (``classical'') action and effective action
functionals, respectively, a special Grassmann integral equation is being
established and solved which also is equivalent to a coupled system of
nonlinear matrix equations. If \lambda \not= 1, solutions to this Grassmann
integral equation exist for n=2 (and consequently, also for any even value of
n, specifically, for n=4) but not for n=3. If \lambda=1, the considered
Grassmann integral equation has always a solution which corresponds to a
Gaussian integral, but remarkably in the case n=4 a further solution is found
which corresponds to a non-Gaussian integral. The investigation sheds light on
the structures to be met for Grassmann algebras G_2n with arbitrarily chosen n.Comment: 58 pages LaTeX (v2: mainly, minor updates and corrections to the
reference section; v3: references [4], [17]-[21], [39], [46], [49]-[54],
[61], [64], [139] added
Spin Orientation and Spin Precession in Inversion-Asymmetric Quasi Two-Dimensional Electron Systems
Inversion asymmetry induced spin splitting of the electron states in quasi
two-dimensional (2D) systems can be attributed to an effective magnetic field B
which varies in magnitude and orientation as a function of the in-plane wave
vector k||. Using a realistic 8x8 Kane model that fully takes into account spin
splitting because of both bulk inversion asymmetry and structure inversion
asymmetry we investigate the spin orientation and the effective field B for
different configurations of a quasi 2D electron system. It is shown that these
quantities depend sensitively on the crystallographic direction in which the
quasi 2D system was grown as well as on the magnitude and orientation of the
in-plane wave vector k||. These results are used to discuss how spin-polarized
electrons can precess in the field B(k||). As a specific example we consider
GaInAs-InP quantum wells.Comment: 10 pages, 6 figure
Early Educational Intervention, Early Cumulative Risk, and the Early Home Environment as Predictors of Young Adult Outcomes Within a High-Risk Sample
The extent to which early educational intervention, early cumulative risk, and the early home environment were associated with young adult outcomes was investigated in a sample of 139 young adults (age 21) from high-risk families enrolled in randomized trials of early intervention. Positive effects of treatment were found for education attainment, attending college, and skilled employment; negative effects of risk were found for education attainment, graduating high school, being employed and avoiding teen parenthood. The home mediated the effects of risk for graduating high school, but not being employed or teen parenthood. Evidence for moderated mediation was found for educational attainment; the home mediated the association between risk and educational attainment for the control group, but not the treated group
A Deep Learning based Pipeline for Efficient Oral Cancer Screening on Whole Slide Images
Oral cancer incidence is rapidly increasing worldwide. The most important
determinant factor in cancer survival is early diagnosis. To facilitate large
scale screening, we propose a fully automated pipeline for oral cancer
detection on whole slide cytology images. The pipeline consists of fully
convolutional regression-based nucleus detection, followed by per-cell focus
selection, and CNN based classification. Our novel focus selection step
provides fast per-cell focus decisions at human-level accuracy. We demonstrate
that the pipeline provides efficient cancer classification of whole slide
cytology images, improving over previous results both in terms of accuracy and
feasibility. The complete source code is available at
https://github.com/MIDA-group/OralScreen.Comment: Accepted to ICIAR 202
Adult outcomes as a function of an early childhood educational program: An Abecedarian Project follow-up.
Adult (age 30) educational, economic, and social-emotional adjustment outcomes were investigated for participants in the Abecedarian Project, a randomized controlled trial of early childhood education for children from low-income families. Of the original 111 infants enrolled (98% African American), 101 took part in the age-30 follow-up. Primary indicators of educational level, economic status, and social-adjustment were examined as a function of early childhood treatment. Treated individuals attained significantly more years of education, but income-to-needs ratios and criminal involvement did not vary significantly as a function of early treatment. A number of other indicators were described for each domain. Overall, the findings provide strong evidence for educational benefits, mixed evidence for economic benefits and little evidence for social-adjustment outcomes. Implications for public policy are discussed
Approximate formula for the ground state energy of anyons in 2D parabolic well
We determine approximate formula for the ground state energy of anyons in 2D
parabolic well which is valid for the arbitrary anyonic factor \nu and number
of particles N in the system. We assume that centre of mass motion energy is
not excluded from the energy of the system. Formula for ground state energy
calculated by variational principle contains logarithmic divergence at small
distances between two anyons which is regularized by cut-off parameter. By
equating this variational formula to the analogous formula of Wu near bosonic
limit (\nu ~ 0)we determine the value of the cut-off and thus derive the
approximate formula for the ground state energy for the any \nu and N. We
checked this formula at \nu=1, when anyons become fermions, for the systems
containing two to thirty particles. We find that our approximate formula has an
accuracy within 6%. It turns out, at the big number N limit the ground state
energy has square root dependence on factor \nu.Comment: 7 page
Spintronics: Fundamentals and applications
Spintronics, or spin electronics, involves the study of active control and
manipulation of spin degrees of freedom in solid-state systems. This article
reviews the current status of this subject, including both recent advances and
well-established results. The primary focus is on the basic physical principles
underlying the generation of carrier spin polarization, spin dynamics, and
spin-polarized transport in semiconductors and metals. Spin transport differs
from charge transport in that spin is a nonconserved quantity in solids due to
spin-orbit and hyperfine coupling. The authors discuss in detail spin
decoherence mechanisms in metals and semiconductors. Various theories of spin
injection and spin-polarized transport are applied to hybrid structures
relevant to spin-based devices and fundamental studies of materials properties.
Experimental work is reviewed with the emphasis on projected applications, in
which external electric and magnetic fields and illumination by light will be
used to control spin and charge dynamics to create new functionalities not
feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes
from the published versio
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