Cluster pre-existence probability

Pre-existence probability of the fragments for the complete binary spectrum of different systems such as 56Ni, 116Ba, 226Ra and 256Fm are calculated, from the overlapping part of the interaction potential using the WKB approximation. The role of reduced mass as well as the classical hydrodynamical mass in the WKB method is analysed. Within WKB, even for negative Q -value systems, the pre-existence probability is calculated. The calculations reveal rich structural information. The calculated results are compared with the values of preformed cluster model of Gupta and collaborators. The mass asymmetry motion is shown here for the first time as a part of relative separation motion

Dynamics of collinear ternary fission in the fragmentation of

With the observation of the collinear cluster tripartition in 252Cf, we discuss various features of the true ternary fission (collinear fission). The conditions for collinear ternary decay with three clusters are explained. We discuss the potential energy surfaces for ternary decay and conditions for the collinear decay

Online monitoring of cold metal transfer (CMT) process using infrared thermography

Online (passive) thermographic inspection of overlap joints of aluminium and zinc coated steel sheets made by cold metal transfer weld brazing process was explored. Different experimental trials were conducted for demonstrating the feasibility of thermographic inspection to detect the porosities, improper weld bead and to differentiate the pre weld temperature. The whole process was monitored using infrared cameras in different wavelength region. Image analysis algorithms were developed to reconstruct the thermal images that contain the signatures of the weld defects and to extract the pre weld temperature and its evolution with distance from the centre of the weld torch. Post-weld radiography lends strong support to the observations

Towards verifying correctness of wireless sensor network applications using insense and spin

The design and implementation of wireless sensor network applications often require domain experts, who may lack expertise in software engineering, to produce resource-constrained, concurrent, real-time software without the support of high-level software engineering facilities. The Insense language aims to address this mismatch by allowing the complexities of synchronisation, memory management and event-driven programming to be borne by the language implementation rather than by the programmer. The main contribution of this paper is an initial step towards verifying the correctness of WSN applications with a focus on concurrency. We model part of the synchronisation mechanism of the Insense language implementation using Promela constructs and verify its correctness using Spin. We demonstrate how a previously published version of the mechanism is shown to be incorrect by Spin, and give complete verification results for the revised mechanism

Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus

Background: In about half of all patients with a suspected monogenic disease, genomic investigations fail to identify the diagnosis. A contributing factor is the difficulty with repetitive regions of the genome, such as those generated by segmental duplications. The ATAD3 locus is one such region, in which recessive deletions and dominant duplications have recently been reported to cause lethal perinatal mitochondrial diseases characterized by pontocerebellar hypoplasia or cardiomyopathy, respectively. Methods: Whole exome, whole genome and long-read DNA sequencing techniques combined with studies of RNA and quantitative proteomics were used to investigate 17 subjects from 16 unrelated families with suspected mitochondrial disease. Findings: We report six different de novo duplications in the ATAD3 gene locus causing a distinctive presentation including lethal perinatal cardiomyopathy, persistent hyperlactacidemia, and frequently corneal clouding or cataracts and encephalopathy. The recurrent 68 Kb ATAD3 duplications are identifiable from genome and exome sequencing but usually missed by microarrays. The ATAD3 duplications result in the formation of identical chimeric ATAD3A/ATAD3C proteins, altered ATAD3 complexes and a striking reduction in mitochondrial oxidative phosphorylation complex I and its activity in heart tissue. Conclusions: ATAD3 duplications appear to act in a dominant-negative manner and the de novo inheritance infers a low recurrence risk for families, unlike most pediatric mitochondrial diseases. More than 350 genes underlie mitochondrial diseases. In our experience the ATAD3 locus is now one of the five most common causes of nuclear-encoded pediatric mitochondrial disease but the repetitive nature of the locus means ATAD3 diagnoses may be frequently missed by current genomic strategies. Funding: Australian NHMRC, US Department of Defense, Japanese AMED and JSPS agencies, Australian Genomics Health Alliance and Australian Mito Foundation