Effect of coriander seeds on hexachlorocyclohexane induced lipid peroxidation in rat liver

The effect of prefeeding of coriander seed powder (CSP) at 10% level on hexachlorocyclohexane (HCH) induced oxidative stress in rat liver was studied. The prefeeding of rats with CSP was found to reduce the HCH-induced rise in conjugated dienes, hydroperoxide and malondialdehyde (MDA) contents in liver. The intra peritonial injection of HCH reduced hepatic superoxide dismutase (SOD), catalase, glutathione S-transferase (GS-t), glucose-6-phosphate dehydrogenase (G-6-PDH) and glutathione reductase (GSSGR) activities in liver, where as the hepatic glutathione peroxidase (GSH-Px) and kidney γ-glutamyltranspeptidase (GGT) activities were elevated. The prefeeding of CSP per se increased hepatic SOD, catalase, GS-t, G-6-PDH and GSSGR activities as well as in CSP prefed and then HCH-administered rats. The work shows the modulation of hepatic antioxidant system as a result of the prefeeding of CSP, which were otherwise reduced by HCH injection. The results reported here elicit the antioxidative effect of coriander seeds against HCH-induced formation of free radicals in rat liver

Protective effects of amla on oxidative stress and toxicity in rats challenged with dimethyl hydrazine

The protective effects of amla on oxidative stress and toxicity in rats challenged with dimethyl hydrazine (DMH) were studied. Experiments involving administration of amla at 5% and 10% levels with simultaneous administration of DMH were studied. Amla at both concentrations increased the hepatic GSH and reduced the conjugated dienes. The DMH-induced increase in hepatic malondialdehyde (MDA) was reduced by amla. The co-administration of DMH and 10% amla enhanced the catalase, glutathione peroxidase (GSH-Px) and superoxide dismutase activities in liver. In addition, amla at 10% level per se increased the hepatic ascorbic acid, glutathione (GSH), and antioxidant enzymes while reducing the conjugated dienes, elucidating the protective effect of amla. Amla elevated the colonic glucose-6-phosphate dehydrogenase (G-6-PDH) activity at the 10% level of feeding. The increased GSH associated with GSH-Px may help in reducing the formation of oxidant stress, as observed by the decrease in MDA after amla incorporation. The observed increase in NADPH-dependent glutathione reductase was effective especially in maintaining cellular homeostasis of GSH. It was noted that in rats treated with DMH and fed with 10% amla, the micronuclei formation was reduced by 58% as compared to DMH injected ones. The activity of γ-glutamyl transpeptidase, which was increased significantly ( P < 0.001) in kidney upon DMH injection, was reduced by 50% on feeding. amla. The results of this study suggest that amla has the ability to detoxify the DMH partly by enhancing the multicomponent antioxidant system in the rat

Brésil, Itaú Cultural

The two last decades have seen the strengthening of cultural institutions through support from companies and financial institutions in Brazil. Criticism over the controversial intentions of those centers (particularly regarding the advantage gained from tax incentives) aside, one of the most important is Itaú Cultural. Founded in 1987, it now has a vast range of activities, including in literature and theater. Particularly useful are the “Rumos Program” (created in 1997 to stimulate the produ..