8 research outputs found
Thermodynamic Limit for Spin Glasses. Beyond the Annealed Bound
Using a correlation inequality of Contucci and Lebowitz for spin glasses, we
demonstrate existence of the thermodynamic limit for short-ranged spin glasses,
under weaker hypotheses than previously available, namely without the
assumption of the annealed bound.Comment: 8 page
Herman's Theory Revisited
We prove that a -smooth orientation-preserving circle
diffeomorphism with rotation number in Diophantine class ,
, is -smoothly conjugate to a rigid
rotation. We also derive the most precise version of Denjoy's inequality for
such diffeomorphisms.Comment: 10 page
Singular measures in circle dynamics
Critical circle homeomorphisms have an invariant measure totally singular
with respect to the Lebesgue measure. We prove that singularities of the
invariant measure are of Holder type. The Hausdorff dimension of the invariant
measure is less than 1 but greater than 0
Approach to equilibrium for a class of random quantum models of infinite range
We consider random generalizations of a quantum model of infinite range
introduced by Emch and Radin. The generalization allows a neat extension from
the class of absolutely summable lattice potentials to the optimal class
of square summable potentials first considered by Khanin and Sinai and
generalised by van Enter and van Hemmen. The approach to equilibrium in the
case of a Gaussian distribution is proved to be faster than for a Bernoulli
distribution for both short-range and long-range lattice potentials. While
exponential decay to equilibrium is excluded in the nonrandom case, it is
proved to occur for both short and long range potentials for Gaussian
distributions, and for potentials of class in the Bernoulli case. Open
problems are discussed.Comment: 10 pages, no figures. This last version, to appear in J. Stat. Phys.,
corrects some minor errors and includes additional references and comments on
the relation to experiment
Acute kidney injury in patients treated with immune checkpoint inhibitors
BACKGROUND: Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has emerged as an important toxicity among patients with cancer. METHODS: We collected data on 429 patients with ICPi-AKI and 429 control patients who received ICPis contemporaneously but who did not develop ICPi-AKI from 30 sites in 10 countries. Multivariable logistic regression was used to identify predictors of ICPi-AKI and its recovery. A multivariable Cox model was used to estimate the effect of ICPi rechallenge versus no rechallenge on survival following ICPi-AKI. RESULTS: ICPi-AKI occurred at a median of 16 weeks (IQR 8-32) following ICPi initiation. Lower baseline estimated glomerular filtration rate, proton pump inhibitor (PPI) use, and extrarenal immune-related adverse events (irAEs) were each associated with a higher risk of ICPi-AKI. Acute tubulointerstitial nephritis was the most common lesion on kidney biopsy (125/151 biopsied patients [82.7%]). Renal recovery occurred in 276 patients (64.3%) at a median of 7 weeks (IQR 3-10) following ICPi-AKI. Treatment with corticosteroids within 14 days following ICPi-AKI diagnosis was associated with higher odds of renal recovery (adjusted OR 2.64; 95% CI 1.58 to 4.41). Among patients treated with corticosteroids, early initiation of corticosteroids (within 3 days of ICPi-AKI) was associated with a higher odds of renal recovery compared with later initiation (more than 3 days following ICPi-AKI) (adjusted OR 2.09; 95% CI 1.16 to 3.79). Of 121 patients rechallenged, 20 (16.5%) developed recurrent ICPi-AKI. There was no difference in survival among patients rechallenged versus those not rechallenged following ICPi-AKI. CONCLUSIONS: Patients who developed ICPi-AKI were more likely to have impaired renal function at baseline, use a PPI, and have extrarenal irAEs. Two-thirds of patients had renal recovery following ICPi-AKI. Treatment with corticosteroids was associated with improved renal recovery
Spin Glass Identities and the Nishimori Line
For a general spin glass model with asymmetric couplings we prove a family of identities involving expectations of generalized overlaps and magnetizations in the quenched state. Those identities hold pointwise in the Nishimori line and are reached at the rate of the inverse volume while, in the general case, they can be proved in integral averag