6 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- AlarcĂłn-MartĂn Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
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- Amouyel Philippe
- Anastasiou A.
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- Zulaica M.
- Ălvarez V.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Threats from the air: Damselfly predation on diverse prey taxa
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
To understand the diversity and strength of predation in natural communities, researchers must quantify the total amount of prey species in the diet of predators. Metabarcoding approaches have allowed widespread characterization of predator diets with high taxonomic resolution. To determine the wider impacts of predators, researchers should combine DNA techniques with estimates of population size of predators using markâreleaseârecapture (MRR) methods, and with accurate metrics of food consumption by individuals. Herein, we estimate the scale of predation exerted by four damselfly species on diverse prey taxa within a well-defined 12-ha study area, resolving the prey species of individual damselflies, to what extent the diets of predatory species overlap, and which fraction of the main prey populations are consumed. We identify the taxonomic composition of diets using DNA metabarcoding and quantify damselfly population sizes by MRR. We also use predator-specific estimates of consumption rates, and independent data on prey emergence rates to estimate the collective predation pressure summed over all prey taxa and specific to their main prey (non-biting midges or chironomids) of the four damselfly species. The four damselfly species collectively consumed a prey mass equivalent to roughly 870 (95% CL 410â1,800)
Immunohistolocalization of Carbonic Anhydrase Isozyme (CA-VI) in Bovine Mammary Glands
- Author
- Breton S.
- Feldstein J. B. and Silverman, D. N.
- Henkin R.I., Martin, B.M. and Agarwal, R.P.
- Henkin R.I., Martin, B.M. and Agarwal, R.P.
- KADOYA Y
- Kivela J., Parkkila, S., Parkkila, A.K., Leinonen, J. and Rajaniemi, H.
- Leinonen J., Parkkila, S., Kaunisto, K., Koivunen, P. and Rajaniemi, H.
- Murakami H. and Sly, W. S.
- Ogawa Y., Chang, C.K., Kuwahara, H., Hong, S.S., Toyosawa, S. and Yagi, T.
- Ogawa Y., Hong, S.S., Toyosawa, S., Kuwahara, H., Shimazaki, M. and Yagi, T.
- Ogawa Y., Matsumoto, K., Maeda, T., Tamai, R., Suzuki, T., Sasano, H. and Fernley, R.T.
- Ogawa Y., Toyosawa, S., Inagaki, T., Hong, S.S. and Ijuhin, N.
- Parkkila S., Kaunisto, K., Rajaniemi, L., Kumpulainen, T., Jokinen, K. and Rajaniemi, H.
- Peagler F.D., Redman, R.S., NcNutt, R.L., Kruse, D.H. and Johansson, I.
- SAKAI K
- Tashian R.E.
- Tashian R.E.
- Veronesi R., Cecin, H., Correa, A., Tavares, J., Moraes, C. and Bertoldo, O.J.
- Wilbur K.M. and Anderson, N.G.
- Publication venue
- 'Japanese Society of Veterinary Science'
- Publication date
- 01/01/2003
- Field of study
Newest aspects on the association between migraine and cardiovascular disease: The role of modifying factors
- Author
- A. Mosek
- A. Oterino
- A. Oterino
- A. Pezzini
- A.I. Scher
- A.I. Scher
- B. Ahmed
- C. Tzourio
- C.L. Chang
- E. Tronvik
- E. Zintzaras
- E.J. Mulder
- F. Bottini
- F.H. Vanmolkot
- G. Liew
- G.E. Tietjen
- H. Kowa
- H. Kowa
- H. Uyarel
- I. Kara
- I. Kara
- J. Schwaiger
- J.B. Henrich
- J.J. Lin
- J.P. Casas
- K.M. Rose
- L.R. MacClellan
- M. Donaghy
- M. Etminan
- M. SchĂŒrks
- M. SchĂŒrks
- M.A. Kaunisto
- M.A. Moskowitz
- M.G. Bousser
- Markus SchĂŒrks
- P.E. Stang
- R.A. Lea
- R.A. Lea
- S. Paterna
- S. Paterna
- S. Schwaag
- S.J. Lewis
- T. Kurth
- T. Kurth
- T. Kurth
- T. Kurth
- Tobias Kurth
- U. Todt
- W. Rosamond
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
DNA Barcoding: Methods and Approaches
- Author
- A. Crespo
- A. Valentini
- A.E. Radulovici
- A.J. Fazekas
- B. McClenaghan
- C. FĂ©randon
- C. L. Schoch
- C. Rinke
- C.A. Harms-Tuohy
- C.E. Bullerwell
- C.J. Nock
- C.S. Ford
- D. Begerow
- D. Huang
- D. Porco
- D.L. Hawksworth
- D.L. Hawksworth
- D.L. Nanney
- E. Stackebrandt
- E. Zuckerkandl
- F. Sanger
- F.T. Krell
- G. Drouin
- G.F. Richard
- J. Lobo
- J. Pawlowski
- J. Pawlowski
- J. Schmit
- J. Xu
- J. Xu
- J.K. Kulski
- J.P. Gogarten
- J.W.O. Ballard
- K. Hoef-Emden
- K. Äandek
- K.H. Wolfe
- K.M. Kaunisto
- K.W. Will
- L. Dupont
- M. Bernt
- M. Blaxter
- M. De Barba
- M. Hajibabaei
- M. Hajibabaei
- M. Weiss
- M.T.P. Gilbert
- M.W. Chase
- N. Rohland
- N.C. Kane
- N.V. Ivanova
- O. Folmer
- P. Hammond
- P. Huemer
- P. Taberlet
- P. Taberlet
- P.D.N. Hebert
- P.D.N. Hebert
- P.D.N. Hebert
- P.D.N. Hebert
- P.M. Hollingsworth
- P.M. Hollingsworth
- P.S. Soltis
- Paul D. N. Hebert
- Q. Wang
- R. DeSalle
- R. Massana
- R.A. King
- S. Cameron
- S. Geisen
- S. Martinsson
- S. Ratnasingham
- S.M. Adl
- S.R. Gilmore
- S.V. Shekhovtsov
- S.V. Shekhovtsov
- S.V. Shekhovtsov
- S.V. Shekhovtsov
- S.V. Shekhovtsov
- Sergio Vargas
- T.H. Eickbush
- T.L. Shearer
- V.S. Shneer
- V.S. Shneyer
- W.J. Kress
- W.Y. Wang
- X. Li
- Y. Jiao
- Z. Li
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)