Co-construction of narrative in verbally able children with autism.

The aim of this paper is to review the research literature on characteristics of narrative in autism in order to specify more clearly the relative abilities and deficits of children with autism in this mode of social communication. The paper first considers how narrative can provide information about the way in which we understand and engage in social exchanges. It then provides a framework for the large body of literature on narrative in typically developing children and this is defined within three parameters of narrative described by Norbury and Bishop (2003). The review considers social communication and pragmatic language in autism before describing in more depth the main studies investigating narrative in autism. It concludes with theoretical implications of narrative ability with autism and reflects upon the value of using narrative as a tool for exploring social understanding

Elastic constants of 3-, 4- and 6-connected chiral and anti-chiral honeycombs subject to uniaxial in-plane loading

Finite Element models are developed for the in-plane linear elastic constants of a family of honeycombs comprising arrays of cylinders connected by ligaments. Honeycombs having cylinders with 3, 4 and 6 ligaments attached to them are considered, with two possible configurations explored for each of the 3- (trichiral and anti-trichiral) and 4- (tetrachiral and anti-tetrachiral) connected systems. Honeycombs for each configuration have been manufactured using rapid prototyping and subsequently characterised for mechanical properties through in-plane uniaxial loading to verify the models. An interesting consequence of the family of 'chiral' honeycombs presented here is the ability to produce negative Poisson's ratio (auxetic) response. The deformation mechanisms responsible for auxetic functionality in such honeycombs are discussed

Hanford Cost Saving Plan

Fiscal Year (FY) 1995 challenged us to dramatically reduce costs at Hanford. We began the year with an 8 percent reduction in our Environmental Management budget but at the same time were tasked with accomplishing additional workscope. This resulted in a Productivity Challenge whereby we took on more work at the beginning of the year than we had funding to complete. During the year, the Productivity Challenge actually grew to 23 percent because of recissions, Congressional budget reductions, and DOE Headquarters actions. We successfully met our FY 1995 Productivity Challenge through an aggressive cost reduction program that identified and eliminated unnecessary workscope and found ways to be more efficient. We reduced the size of the workforce, cut overhead expenses, eliminated paperwork, cancelled construction of new facilities, and reengineered our processes. We are proving we can get the job done better and for less money at Hanford. DOE`s drive to do it ``better, faster, cheaper`` has led us to look for more and larger partnerships with the private sector. The biggest will be privatization of Hanford`s Tank Waste Remediation System, which will turn liquid tank waste into glass logs for eventual disposal. We will also save millions of dollars and avoid the cost of replacing aging steam plants by contracting Hanford`s energy needs to a private company. Other privatization successes include the Hanford Mail Service, a spinoff of advanced technical training, low level mixed waste thermal treatment, and transfer of the Hanford Museums of Science and history to a private non-profit organization. Despite the rough roads and uncertainty we faced in FY 1995, less than 3 percent of our work fell behind schedule, while the work that was performed was completed with an 8.6 percent cost under-run. We not only met the FY 1995 productivity challenge, we also met our FY 1995-1998 savings commitments and accelerated some critical cleanup milestones. The challenges continue. Budgets remain on the decline, even while the expectations increase. Yet we are confident in our ability to keep our commitments and goals by identifying new efficiencies in the Hanford cleanup program. We will also pursue new contracting arrangements that will allow us to foster greater competition and use more commercial practices while maintaining our commitment to the safety and health of the public, our workers, and the environment

The health and wellbeing of offshore workers: a narrative review of the published literature.

Recent developments within the offshore industry have highlighted the role that health and wellbeing plays in ensuring the safety and longevity of the offshore workforce. Developing an understanding of the overall health and wellbeing of offshore workers could aid future developments. This narrative review aims to identify and synthesise the relevant published literature on offshore health and wellbeing. The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, Medical Literature Analysis and Retrieval System Online, PsycArticles, and Web of Science databases were searched with publication search dates limited from January 1994 to November 2014. Twenty-six studies were identified and covered aspects of occupational stress; mental wellbeing; body mass index; diet; physical activity; musculoskeletal disorder; smoking; alcohol and drug use; shift work amongst offshore workers. This narrative review has highlighted a lack of high quality and relevant research. There is a particular need to research workers' participation in self care activities and the resultant influence of domains on health and well being. NOTE: publisher link is not currently working (last checked 2019-01-25

Using familial information for variant filtering in high-throughput sequencing studies

High-throughput sequencing studies (HTS) have been highly successful in identifying the genetic causes of human disease, particularly those following Mendelian inheritance. Many HTS studies to date have been performed without utilizing available family relationships between samples. Here, we discuss the many merits and occasional pitfalls of using identity by descent information in conjunction with HTS studies. These methods are not only applicable to family studies but are also useful in cohorts of apparently unrelated, 'sporadic' cases and small families underpowered for linkage and allow inference of relationships between individuals. Incorporating familial/pedigree information not only provides powerful filtering options for the extensive variant lists that are usually produced by HTS but also allows valuable quality control checks, insights into the genetic model and the genotypic status of individuals of interest. In particular, these methods are valuable for challenging discovery scenarios in HTS analysis, such as in the study of populations poorly represented in variant databases typically used for filtering, and in the case of poor-quality HTS data

Measurement of species flux from a bubble using an acousto-electrochemical technique

An acousto-electrochemical technique is presented which, for the first time, offers the potential for measuring the flux of dissolved species in a liquid resulting from bubbles of a specific chosen size in the population. Laboratory trials are presented, but the device itself was damaged in the surf zone and no data was obtained from the ocean deployment. Nevertheless, the preceding laboratory tests demonstrate the viability of the technique. The device responds to perturbations of the fluid around a small electrode. Three such sources of motion must be characterised if it is to achieve the objective stated above. First, the perturbations resulting form the translatory motions of bubbles in the liquid. To obtain bubble radius resolution in the measurement of mass flux, however, it is necessary to apply to driving (‘pump’) sound field. Bubbles close to resonance will, in addition to a translatory motion, impart to the liquid a component of mass flux at the pump frequency. This is detected. However to show that this is the result of bubble wall pulsation, and not someother coupling, the amplitude of the pump field is increased until the electrochemical sensor detects Faraday waves on the bubble wall. Not only does this prove the relation between mass flux to bubble wall motion, it provides a second route by which the radius-resolved component of mass flux might be identified. In these preliminary laboratory tests, electrochemical detection of these motions was achieved through the observation of current produced by the reduction of a suitable redox agent present within the liquid phase of the solution employed. Preparations were made to obtain preliminary data from the Hurst Spit 2000 surf zone trial, but the device was damaged by the environment

Spatial and temporal variation in sponge spicule patches at Station M, northeast Pacific

Changes in habitat-forming organisms can have complex consequences for associated species. Sessile epibenthic glass “plate” sponges (Porifera: Hexactinellida) are conspicuous inhabitants of soft-sediment abyssal areas and their siliceous spicules create persistent spicule patches on the seafloor. Sponge spicule patch density, spatial dispersion, and percent cover were examined over a seven-year period (2006–2013) using remotely operated vehicle videos from Station M in the abyssal northeast Pacific (50˚00N, 123˚00W, ~4,000 m depth). There was an apparent large increase in newly dead plate sponges in February 2007 compared with December 2006, with this trend continuing through June 2007 (mean 0.03 % cover increasing to 0.33 %). A second increase in mean percent cover of dead plate sponges occurred from May 2011 (0.24 %) through June 2012 (0.60 %). Among the 28 megafaunal taxa occurring in association with the patches, the distributions of three taxa [two sponge taxa (Porifera) and brittle stars (Ophiuroidea)] suggested selectivity for the sponge spicule patches. The community structure of visible megafauna within sponge spicule patches was different when compared with that outside the patches suggesting that the sponges, after death, provide preferred habitat patches for certain benthic megafauna. These findings indicate that sponge spicule patches contribute to habitat heterogeneity in space and time

Modelling spatial and inter-annual variations of nitrous oxide emissions from UK cropland and grasslands using DailyDayCent

This work contributes to the Defra funded projects AC0116: ‘Improving the nitrous oxide inventory’, and AC0114: ‘Data Synthesis, Management and Modelling’. Funding for this work was provided by the UK Department for Environment, Food and Rural Affairs (Defra) AC0116 and AC0114, the Department of Agriculture, Environment and Rural Affairs for Northern Ireland, the Scottish Government and the Welsh Government. Rothamsted Research receives strategic funding from the Biotechnology and Biological Sciences Research Council. This study also contributes to the projects: N-Circle (BB/N013484/1), U-GRASS (NE/M016900/1) and GREENHOUSE (NE/K002589/1).Peer reviewedPublisher PD

Mouse Anesthesia: The Art and Science

There is an art and science to performing mouse anesthesia, which is a significant component to animal research. Frequently, anesthesia is one vital step of many over the course of a research project spanning weeks, months, or beyond. It is critical to perform anesthesia according to the approved research protocol using appropriately handled and administered pharmaceutical-grade compounds whenever possible. Sufficient documentation of the anesthetic event and procedure should also be performed to meet the legal, ethical, and research reproducibility obligations. However, this regulatory and documentation process may lead to the use of a few possibly oversimplified anesthetic protocols used for mouse procedures and anesthesia. Although a frequently used anesthetic protocol may work perfectly for each mouse anesthetized, sometimes unexpected complications will arise, and quick adjustments to the anesthetic depth and support provided will be required. As an old saying goes, anesthesia is 99% boredom and 1% sheer terror. The purpose of this review article is to discuss the science of mouse anesthesia together with the art of applying these anesthetic techniques to provide readers with the knowledge needed for successful anesthetic procedures. The authors include experiences in mouse inhalant and injectable anesthesia, peri-anesthetic monitoring, specific procedures, and treating common complications. This article utilizes key points for easy access of important messages and authors’ recommendation based on the authors’ clinical experiences