13 research outputs found
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- Author
- Abbasalizad-Farhangi M.
- Abbasi M.
- Abbastabar H.
- Abdelalim A.
- Abdoli A.
- Abdollahi M.
- Abdollahpour I.
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- Younis M.Z.
- Yousefi Z.
- Yousof H.-A.S.A.
- Yu C.
- Yusefzadeh H.
- Zahabi S.S.
- Zaki L.
- Zaman S.B.
- Zamani M.
- Zamanian M.
- Zandian H.
- Zarafshan H.
- Zepro N.B.
- Zerfu T.A.
- Zewale T.A.
- Zhang Y.
- Zhang Z.-J.
- Zhao X.-J.
- Zodpey S.
- Zomorodian K.
- Zotor F.B.
- �rnlöv J.
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Get PDFA double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4 (62.3 (55.1�70.8) million) to 6.4 (58.3 (47.6�70.7) million), but is predicted to remain above the World Health Organization�s Global Nutrition Target of <5 in over half of LMICs by 2025. Prevalence of overweight increased from 5.2 (30 (22.8�38.5) million) in 2000 to 6.0 (55.5 (44.8�67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic. © 2020, The Author(s)
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)
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Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)
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Get PDFAn amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s)
EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models
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- Publication venue
- Publication date
- 01/01/1993
- Field of study
No full textNeuroprotection and free radical scavenging effects of Osmanthus fragrans
- Author
- A. Simonyi
- B. Ahlemeyer
- B. Friguls
- B. Zhao
- C. Deng
- C.C. Wang
- Chi-Ting Lin
- D.C. Hess
- F. Dajas
- G. Jin
- H. Ohkawa
- H.H. Lee
- Hsin-Hsueh Lee
- J. Liu
- K. Yazawa
- K.A. Youdim
- K.J. Kwon
- K.L. Double
- K.L. Double
- Ling-Ling Yang
- M. Ahmad
- M. Antolovich
- M. Rudakewich
- M.A. Gyamfi
- N. Pellegrini
- O.H. Lowry
- P.H. Chan
- S.L. Mehta
- T. Montiel
- T.C. Dinis
- X.P. Zhuang
- Y.J. Kwon
- Publication venue
- 'Springer Science and Business Media LLC'
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No full textMotor cortical excitability and pre-supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2023
- Field of study
Get PDFSubstantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. We hypothesized that SN hyperechogenicity in healthy adults aged 50–70 years is associated with reduced short-interval intracortical inhibition in primary motor cortex, and that the reduced intracortical inhibition is associated with neurochemical markers of activity in the pre-supplementary motor area (pre-SMA). Short-interval intracortical inhibition and intracortical facilitation in primary motor cortex was assessed with paired-pulse transcranial magnetic stimulation in 23 healthy adults with normal (n = 14; 61 ± 7 yrs) or abnormally enlarged (hyperechogenic; n = 9; 60 ± 6 yrs) area of SN echogenicity. Thirteen of these participants (7 SN− and 6 SN+) also underwent brain magnetic resonance spectroscopy to investigate pre-SMA neurochemistry. There was no relationship between area of SN echogenicity and short-interval intracortical inhibition in the ipsilateral primary motor cortex. There was a significant positive relationship, however, between area of echogenicity in the right SN and the magnitude of intracortical facilitation in the right (ipsilateral) primary motor cortex (p = .005; multivariate regression), evidenced by the amplitude of the conditioned motor evoked potential (MEP) at the 10–12 ms interstimulus interval. This relationship was not present on the left side. Pre-SMA glutamate did not predict primary motor cortex inhibition or facilitation. The results suggest that SN hyperechogenicity in healthy older adults may be associated with changes in excitability of motor cortical circuitry. The results advance understanding of brain changes in healthy older adults at risk of Parkinson's disease.Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina von Thaler, Clarence Chiang, Kay L. Doubl
SR Microbeam Analysis at Cellular Level
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
No full textDopamine and Neurodegeneration
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No full textStrategies for the protection of dopaminergic neurons against neurotoxicity
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- A. Boireau
- A. Clow
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No full textNeuroprotective and neurorestorative strategies for neuronal injury
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- A. Fredriksson
- A. Friedlich
- A. Kalda
- A. Nordberg
- A. Wong
- A.F. Miranda
- A.H. Schapira
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