253 research outputs found
Quantum noise in current biased Josephson junction
Quantum fluctuations in a current biased Josephson junction, described in
terms of the RCSJ-model, are considered. The fluctuations of the voltage and
phase across the junction are assumed to be initiated by equilibrium current
fluctuations in the shunting resistor. This corresponds to low enough
temperatures, when fluctuations of the normal current in the junction itself
can be neglected. We used the quantum Langevin equation in terms of random
variables related to the limit cycle of the nonlinear Josephson oscillator.
This allows to go beyond the perturbation theory and calculate the widths of
the Josephson radiation lines
Morris-Thorne wormholes with a cosmological constant
First, the ideas introduced in the wormhole research field since the work of
Morris and Thorne are briefly reviewed, namely, the issues of energy
conditions, wormhole construction, stability, time machines and astrophysical
signatures. Then, spherically symmetric and static traversable Morris-Thorne
wormholes in the presence of a generic cosmological constant are analyzed. A
matching of an interior solution to the unique exterior vacuum solution is done
using directly the Einstein equations. The structure as well as several
physical properties and characteristics of traversable wormholes due to the
effects of the cosmological term are studied. Interesting equations appear in
the process of matching. For instance, one finds that for asymptotically flat
and anti-de Sitter spacetimes the surface tangential pressure of the
thin-shell, at the boundary of the interior and exterior solutions, is always
strictly positive, whereas for de Sitter spacetime it can take either sign as
one could expect, being negative (tension) for relatively high cosmological
constant and high wormhole radius, positive for relatively high mass and small
wormhole radius, and zero in-between. Finally, some specific solutions with
generic cosmological constant, based on the Morris-Thorne solutions, are
provided.Comment: latex, 49 pages, 8 figures. Expanded version of the paper published
in Physical Review
Rationale, design and objectives of two phase III, randomised, placebo-controlled studies of GLPG1690, a novel autotaxin inhibitor, in idiopathic pulmonary fibrosis (ISABELA 1 and 2)
Introduction While current standard of care (SOC)
for idiopathic pulmonary fibrosis (IPF) slows disease
progression, prognosis remains poor. Therefore, an unmet
need exists for novel, well-tolerated agents that reduce
lung function decline and improve quality of life. Here we
report the design of two phase III studies of the novel IPF
therapy, GLPG1690.
Methods and analysis Two identically designed, phase
III, international, randomised, double-blind, placebocontrolled, parallel-group, multicentre studies (ISABELA 1
and 2) were initiated in November 2018. It is planned that,
in each study, 750 subjects with IPF will be randomised
1:1:1 to receive oral GLPG1690 600 mg, GLPG1690
200 mg or placebo, once daily, on top of local SOC, for at
least 52 weeks. The primary endpoint is rate of decline of
forced vital capacity (FVC) over 52 weeks. Key secondary
endpoints are week 52 composite endpoint of disease
progression or all-cause mortality (defined as composite
endpoint of first occurrence of ≥10% absolute decline
in per cent predicted FVC or all-cause mortality at week
52); time to first respiratory-related hospitalisation until
end of study; and week 52 change from baseline in the St
George’s Respiratory Questionnaire total score (a qualityof-life measure).
Ethics and dissemination Studies will be conducted
in accordance with Good Clinical Practice guidelines,
Declaration of Helsinki principles, and local ethical and
legal requirements. Results will be reported in a peerreviewed publication.
Trial registration numbers NCT03711162;
NCT03733444
Production and Decay of D_1(2420)^0 and D_2^*(2460)^0
We have investigated and final states and
observed the two established charmed mesons, the with mass
MeV/c and width MeV/c and
the with mass MeV/c and width
MeV/c. Properties of these final states, including
their decay angular distributions and spin-parity assignments, have been
studied. We identify these two mesons as the doublet predicted
by HQET. We also obtain constraints on {\footnotesize } as a function of the cosine of the relative phase of the two
amplitudes in the decay.Comment: 15 pages in REVTEX format. hardcopies with figures can be obtained by
sending mail to: [email protected]
Measurement of the branching fraction for
We have studied the leptonic decay of the resonance into tau
pairs using the CLEO II detector. A clean sample of tau pair events is
identified via events containing two charged particles where exactly one of the
particles is an identified electron. We find . The result is consistent with
expectations from lepton universality.Comment: 9 pages, RevTeX, two Postscript figures available upon request, CLNS
94/1297, CLEO 94-20 (submitted to Physics Letters B
Study of the B^0 Semileptonic Decay Spectrum at the Upsilon(4S) Resonance
We have made a first measurement of the lepton momentum spectrum in a sample
of events enriched in neutral B's through a partial reconstruction of B0 -->
D*- l+ nu. This spectrum, measured with 2.38 fb**-1 of data collected at the
Upsilon(4S) resonance by the CLEO II detector, is compared directly to the
inclusive lepton spectrum from all Upsilon(4S) events in the same data set.
These two spectra are consistent with having the same shape above 1.5 GeV/c.
From the two spectra and two other CLEO measurements, we obtain the B0 and B+
semileptonic branching fractions, b0 and b+, their ratio, and the production
ratio f+-/f00 of B+ and B0 pairs at the Upsilon(4S). We report b+/b0=0.950
(+0.117-0.080) +- 0.091, b0 = (10.78 +- 0.60 +- 0.69)%, and b+ = (10.25 +- 0.57
+- 0.65)%. b+/b0 is equivalent to the ratio of charged to neutral B lifetimes,
tau+/tau0.Comment: 14 page, postscript file also available at
http://w4.lns.cornell.edu/public/CLN
Measurement of the Decay Asymmetry Parameters in and
We have measured the weak decay asymmetry parameters (\aLC ) for two \LC\
decay modes. Our measurements are \aLC = -0.94^{+0.21+0.12}_{-0.06-0.06} for
the decay mode and \aLC = -0.45\pm 0.31 \pm
0.06 for the decay mode . By combining these
measurements with the previously measured decay rates, we have extracted the
parity-violating and parity-conserving amplitudes. These amplitudes are used to
test models of nonleptonic charmed baryon decay.Comment: 11 pages including the figures. Uses REVTEX and psfig macros. Figures
as uuencoded postscript. Also available as
http://w4.lns.cornell.edu/public/CLNS/1995/CLNS95-1319.p
Observation of the Charmed Baryon Decays to , , and
We have observed two new decay modes of the charmed baryon into
and using data collected with the
CLEO II detector. We also present the first measurement of the branching
fraction for the previously observed decay mode . The branching fractions for these three modes relative to
are measured to be , , and , respectively.Comment: 12 page uuencoded postscript file, postscript file also available
through http://w4.lns.cornell.edu/public/CLN
Measurement of the Mass Splittings between the States
We present new measurements of photon energies and branching fractions for
the radiative transitions: Upsilon(2S)->gamma+chi_b(J=0,1,2). The masses of the
chi_b states are determined from the measured radiative photon energies. The
ratio of mass splittings between the chi_b substates,
r==(M[J=2]-M[J=1])/(M[J=1]-M[J=0]) with M the chi_b mass, provides information
on the nature of the bbbar confining potential. We find
r(1P)=0.54+/-0.02+/-0.02. This value is in conflict with the previous world
average, but more consistent with the theoretical expectation that r(1P)<r(2P);
i.e., that this mass splittings ratio is smaller for the chi_b(1P) triplet than
for the chi_b(2P) triplet.Comment: 11 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
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